Search Results

You are looking at 1 - 1 of 1 items for

  • Author: Julie Dubois-Chevalier x
  • Refine by access: All content x
Clear All Modify Search
Francesco Paolo Zummo University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France

Search for other papers by Francesco Paolo Zummo in
Google Scholar
PubMed
Close
,
Alexandre Berthier University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France

Search for other papers by Alexandre Berthier in
Google Scholar
PubMed
Close
,
Céline Gheeraert University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France

Search for other papers by Céline Gheeraert in
Google Scholar
PubMed
Close
,
Manjula Vinod University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France

Search for other papers by Manjula Vinod in
Google Scholar
PubMed
Close
,
Marie Bobowski-Gérard University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France

Search for other papers by Marie Bobowski-Gérard in
Google Scholar
PubMed
Close
,
Olivier Molendi-Coste University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France
University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 - UAR 2014 - PLBS, Lille, France

Search for other papers by Olivier Molendi-Coste in
Google Scholar
PubMed
Close
,
Laurent Pineau University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France

Search for other papers by Laurent Pineau in
Google Scholar
PubMed
Close
,
Matthieu Jung University of Strasbourg, CNRS UMR 7104, INSERM U1258 - GenomEast Platform - IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France

Search for other papers by Matthieu Jung in
Google Scholar
PubMed
Close
,
Loic Guille University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France

Search for other papers by Loic Guille in
Google Scholar
PubMed
Close
,
Julie Dubois-Chevalier University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France

Search for other papers by Julie Dubois-Chevalier in
Google Scholar
PubMed
Close
,
David Dombrowicz University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France

Search for other papers by David Dombrowicz in
Google Scholar
PubMed
Close
,
Bart Staels University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France

Search for other papers by Bart Staels in
Google Scholar
PubMed
Close
,
Jérôme Eeckhoute University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France

Search for other papers by Jérôme Eeckhoute in
Google Scholar
PubMed
Close
, and
Philippe Lefebvre University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France

Search for other papers by Philippe Lefebvre in
Google Scholar
PubMed
Close

The functional versatility of the liver is paramount for organismal homeostasis. Adult liver functions are controlled by a tightly regulated transcription factor network including nuclear receptors (NRs), which orchestrate many aspects of hepatic physiology. NRs are transcription factors sensitive to extracellular cues such as hormones, lipids, xenobiotics, etc. and are modulated by intracellular signaling pathways. While liver functional zonation and adaptability to fluctuating conditions rely on a sophisticated cellular architecture, a comprehensive knowledge of NR functions within liver cell populations is still lacking. As a step toward the accurate mapping of NR functions in the liver, we characterized their levels of expression in the whole liver from C57Bl6/J male mice as a function of time and diet. Nr1d1 (Rev-erba), Nr1d2 (Rev-erbb), Nr1c2 (Pparb/d), and Nr1f3 (Rorg) exhibited a robust cyclical expression in ad libitum-fed mice which was, like most cyclically expressed NRs, reinforced upon time-restricted feeding. In a few instances, cyclical expression was lost or gained as a function of the feeding regimen. NR isoform expression was explored in purified hepatocytes, cholangiocytes, Kupffer cells, hepatic stellate cells, and liver sinusoidal cells. The expression of some NR isoforms, such as Nr1h4 (Fxra) and Nr1b1 (Rara) isoforms, was markedly restricted to a few cell types. Leveraging liver single-cell RNAseq studies yielded a zonation pattern of NRs in hepatocytes, liver sinusoidal cells, and stellate cells, establishing a link between NR subtissular localization and liver functional specialization. In summary, we provide here an up-to-date compendium of NR expression in mouse liver in space and time.

Restricted access