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Julika Lietzow, Janine Golchert, Georg Homuth, Uwe Völker, Wenke Jonas, and Josef Köhrle

weight. However, unwanted effects on heart, bone, or muscle restrict their use as therapeutically active compounds for obesity-related diseases ( Angelin & Rudling 2010 ). In the last few decades, several TH derivatives have been designed as treatment

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Carmelo Quarta, Roberta Mazza, Renato Pasquali, and Uberto Pagotto

Brown adipose tissue and obesity The key role played by brown adipose tissue (BAT) in energy balance regulation of mammals has been known for decades ( Rothwell & Stock 1979 , Cannon & Nedergaard 2004 ). Because of the high number of mitochondria

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N Hoggard, M Cruickshank, K M Moar, P Barrett, S Bashir, and J D B Miller

diabetic obese ob/ob mice, 24 h fasted C57BL6 mice and in the 3T3-L1 adipocyte cell line. Methods Animals Wild-type and obese ob/ob male mice on the C57BL6 background (all ∼11 weeks old) were purchased from Harlan UK Ltd (Bicester, Oxon, UK). Animals

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Luis Varela, María J Vázquez, Fernando Cordido, Rubén Nogueiras, Antonio Vidal-Puig, Carlos Diéguez, and Miguel López

Ghrelin: a stomach-derived peptide modulating energy balance A large degree of attention has surrounded the prospect of ghrelin becoming a key factor in the fight against obesity. This 28 amino acid peptide hormone, with orexigenic properties

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Hyon-Seung Yi, Joon Young Chang, and Minho Shong

of mitochondrial OxPhos perturbations on systemic energy metabolism that may be relevant in the treatment of obesity and diabetes. We also describe the effects of UPR mt on cellular and systemic physiology during the conditions of mitochondrial

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Chung Thong Lim, Blerina Kola, and Márta Korbonits

slightly increase AMPK activity ( Brabant et al . 2005 ). However, these effects are lost in diet-induced obese rats, thereby suggesting an important physiological dysregulation of leptin effects in obese animals. Leptin inhibits triacylglycerol storage

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A Stevens, C De Leonibus, D Hanson, A W Dowsey, A Whatmore, S Meyer, R P Donn, P Chatelain, I Banerjee, K E Cosgrove, P E Clayton, and M J Dunne

possible to identify genetic biomarkers of growth response which could have important predictive potential. Obesity and adipose tissue Adipose tissue is a host to a number of complex regulatory networks, involving growth, metabolism and intracellular

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D T Furuya, A C Poletto, H S Freitas, and U F Machado

Introduction Obesity has been described as a chronic multifactorial and complex genetic disorder, which is associated with several complications and related comorbidities. The increasing prevalence of obesity remains a major public concern. For this

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Jin-Seung Choung, Young-Sun Lee, and Hee-Sook Jun

, intracerebroventricular administration of GLP1 increased the proportion of fat oxidation in lean and obese Zucker rats ( Hwa et al . 1998 ). Recently, it was reported that brown adipose tissue thermogenesis is controlled by central nervous system GLP1 receptor signaling

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Farhana Naznin, Koji Toshinai, T M Zaved Waise, Tadashi Okada, Hideyuki Sakoda, and Masamitsu Nakazato

Introduction Obesity is a long-term disturbance of energy metabolism in which energy intake exceeds energy expenditure over a prolonged period ( Moehlecke et al . 2016 ). The control of food intake and body weight involves central nervous