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Rajaa El Bekay, Gonzalo Alba, M Edith Reyes, Pedro Chacón, Antonio Vega, José Martín-Nieto, Juan Jiménez, Eladio Ramos, Josefina Oliván, Elízabeth Pintado, and Francisco Sobrino

pathogenesis of vascular diseases ( Mazzone et al . 1993 ). Given that chronic inflammation of vessel walls is a pathological indicator of hypertension ( Touyz 2003 ) and that reactive oxygen species (ROS) such as superoxide anion and H 2 O 2 constitute the

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Dong-Jae Jun, Kyung-Yoon Na, Wanil Kim, Dongoh Kwak, Eun-Jeong Kwon, Jong Hyuk Yoon, Kyungmoo Yea, Hyeongji Lee, Jaeyoon Kim, Pann-Gill Suh, Sung Ho Ryu, and Kyong-Tai Kim

regulator of inflammation, p38 integrates inflammatory responses by regulating several aspects of target gene transcription and translation. p38 enhances both the transcriptional activity of NFκB via acetylation of p65 ( Saha et al . 2007 ) and the

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Huan Zhang, Xiuxia Liu, Shanshan Zhou, Ye Jia, Ying Li, Yuguo Song, Junnan Wang, and Hao Wu

, Periodic acid-Schiff; UACR, urinary albumin to creatinine ratio; WT, wild type. NRF2 was required for SP600125’s alleviation of the diabetes-induced renal oxidative stress, inflammation and fibrosis Renal nitrosative damage was reflected by

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Karen Oliva, Gillian Barker, Clyde Riley, Mark J Bailey, Michael Permezel, Gregory E Rice, and Martha Lappas

. The roles of these proteins in the regulation of placental function, and how they may influence fetus, are discussed below. Inflammation Exposure of the fetus to an intrauterine inflammatory environment may have short and long-term consequences

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Gilberto Paz-Filho, Claudio Alberto Mastronardi, Brian J Parker, Ainy Khan, Antonio Inserra, Klaus I Matthaei, Monika Ehrhart-Bornstein, Stefan Bornstein, Ma-Li Wong, and Julio Licinio

) to non-alcoholic steatohepatitis (NASH) and cirrhosis ( Neuschwander-Tetri & Caldwell 2003 ). Approximately 23% of patients with NAFLD progress to NASH ( Wong et al . 2010 ), which is histologically characterized by steatosis, lobular inflammation

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Krisztina Pohóczky, József Kun, Bálint Szalontai, Éva Szőke, Éva Sághy, Maja Payrits, Béla Kajtár, Krisztina Kovács, József László Környei, János Garai, András Garami, Anikó Perkecz, Levente Czeglédi, and Zsuzsanna Helyes

Introduction Transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) are non-selective cation channels predominantly localized in capsaicin-sensitive peptidergic sensory neurons and mediate pain and inflammation ( Szallasi et al

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Fabio Arturo Grieco, Andrea Alex Schiavo, Flora Brozzi, Jonas Juan-Mateu, Marco Bugliani, Piero Marchetti, and Décio L Eizirik

systems taking place during insulitis ( Eizirik et al. 2009 , 2012 , Santin & Eizirik 2013 , Floyel et al. 2015 ). Islets inflammation triggers endoplasmic reticulum (ER) stress in beta cells exacerbating inflammation and contributing to beta cell

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Qi Zhang, Jing Liu, Jia Liu, Wenhui Huang, Limin Tian, Jinxing Quan, Yunfang Wang, and Ruilan Niu

Introduction Type 2 diabetes mellitus (T2DM) is potentially complicated by hepatic microangiopathy and liver inflammation ( Hudacko et al . 2009 ) and is an independent risk factor for the formation and development of non-alcoholic fatty liver

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Lingyun Zhang, Takashi Sugiyama, Nao Murabayashi, Takashi Umekawa, Ning Ma, Yuki Kamimoto, Yoshihiro Ogawa, and Norimasa Sagawa

Investigation 116 1494 – 1505 . doi:10.1172/JCI26498 . Kawanishi N Yano H Yokogawa Y Suzuki K 2010 Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching

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Qun Cheng, Weipin Dong, Lei Qian, Jingcheng Wu, and Yongde Peng

( Li et al . 2008 ). Visfatin also participates in cellular resistance to genotoxic/oxidative stress, and enhances immune cell survival during stressful situations such as inflammation ( Rongvaux et al . 2008 ). In normal pregnancy, increased SIRT1