Search Results

You are looking at 41 - 50 of 117 items for :

  • All content x
Clear All
Free access

Christopher E Wall, Ruth T Yu, Anne R Atkins, Michael Downes, and Ronald M Evans

fatty acids that can originate from dietary sources, lipolysis of lipid storage in adipose tissues, or de novo lipogenesis ( Dreyer et al . 1993 ). While PPARδ is responsible for regulating its target genes most critically in skeletal muscle, PPARα

Free access

Michelle Colomiere, Michael Permezel, and Martha Lappas

( Sivan et al . 1998 ). In the third trimester, postprandial FFA levels increase and insulin sensitivity worsens by 40–60% compared with pre-pregnancy ( Catalano et al . 1993 , 1999 ). Insulin's ability to suppress whole-body lipolysis is reduced during

Free access

Jessica A Deis, Hong Guo, Yingjie Wu, Chengyu Liu, David A Bernlohr, and Xiaoli Chen

lipolysis to provide fatty acids to support uncoupling of the electron transport chain ( Cao et al . 2001 , 2004 ). However, alternative, non-adrenergic pathways have also been identified as promoting beiging of WAT. The anti-diabetic drug rosiglitazone

Free access

C Folgueira, S Barja-Fernandez, P Gonzalez-Saenz, V Pena-Leon, C Castelao, M Ruiz-Piñon, F F Casanueva, R Nogueiras, and L M Seoane

exert a direct action on human visceral adipocytes stimulating lipolysis through the activation and phosphorylation of HSL and the upregulation of several genes involved in lipid mobilization ( Rodriguez et al . 2016 ). Several studies have shown that

Free access

Andrew Whittle

of its potential substrates ( Misono 2011 ). Lipolysis in adipose tissue following adrenergic stimulation was thought to be solely dependant on cAMP levels, but it has been demonstrated that in white adipocytes, increased cGMP levels following NP

Free access

Ayse Basak Engin, Atilla Engin, and Ipek Isik Gonul

mRNA expression in macrophages through the TLR4/NF-κB pathway. Macrophage-induced adipocyte lipolysis aggravates obesity-induced adipose tissue inflammation by this way ( Ichioka et al. 2011 ). TLR-dependent polarization mediators of M1 macrophages

Free access

Qin He, Dan Mei, Sha Sha, Shanshan Fan, Lin Wang, and Ming Dong

concomitant increase in autophagy flux. It suggested that autophagy may play an absolutely necessary role in lipolysis, which could provide a new way to eliminate lipid accumulation in addition to lipase-mediated lipolysis. Autophagy is regulated by a

Free access

Xu-guang Zhu, Dong Wook Kim, Michael L Goodson, Martin L Privalsky, and Sheue-Yann Cheng

phenotype described here for the TRα1-PV mutation, a TRα1-P398H mutation produced visceral adiposity, hyperleptinemia, reduced sensitivity to catecholamine-stimulated lipolysis, and hepatic steatosis ( Liu et al . 2003 ). These divergent metabolic outcomes

Free access

Ewa Harasim-Symbor, Karolina Konstantynowicz-Nowicka, and Adrian Chabowski

adipose tissue lipolysis and increases the content of fatty acids in plasma ( Han et al . 2015 ). In conclusion, the above-mentioned disturbances may be evoked by both endogenous and exogenous glucocorticoids, which play a pivotal role in the pathogenesis

Free access

Guojun Shi, Chen Sun, Weiqiong Gu, Minglan Yang, Xiaofang Zhang, Nan Zhai, Yan Lu, Zhijian Zhang, Peishun Shou, Zhiguo Zhang, and Guang Ning

and regulated gut hormones and motility ( Xiong et al . 2004 , Samuel et al . 2008 ). Then, several other groups argued that FFAR2 rather than FFAR3 inhibited lipolysis and triggered leptin secretion and adipogenesis ( Hong et al . 2005 , Ge et