Search Results

You are looking at 31 - 40 of 249 items for :

  • "insulin secretion" x
  • All content x
Clear All
Free access

Ahter D Sanlioglu, Bahri Karacay, Mustafa Kemal Balci, Thomas S Griffith, and Salih Sanlioglu

related to insulin secretion pathways rather than insulin sensitivity. As single-marker GWAS may generally overlook the potential interaction of multiple genes responsible for the development of disease phenotype, pathway-based GWAS analysis was conducted

Free access

Narudee Kashemsant and Catherine B Chan

available for conversion of ADP to ATP ( Schrauwen & Hesselink 2002 ). Overexpression of UCP2 inhibits glucose-stimulated insulin secretion ( Chan et al. 1999 , 2001 , Hong et al. 2001 ), whereas its absence promotes enhanced insulin release ( Zhang

Free access

Weijuan Shao, Vivian Szeto, Zhuolun Song, Lili Tian, Zhong-Ping Feng, M Cristina Nostro, and Tianru Jin

INS-1 832/13. We have also compared the effect of adenovirus-mediated TCF7L2DN expression and siRNA-mediated Isl1 knockdown on β-cell gene expression, as well as high glucose (HG) and HG plus GLP-1 stimulated insulin secretion. Our observations have

Free access

Qi Cheng, Violeta D Beltran, Stanley M H Chan, Jeremy R Brown, Alan Bevington, and Terence P Herbert

Introduction The branched-chain amino acids (BCAA), leucine, isoleucine and valine, are essential amino acids that play an important role in glucose homeostasis. In vitro , leucine stimulates insulin secretion ( Newsholme et al. 2007 ) and

Free access

S Lortz, S Lenzen, and I Mehmeti

Forward: 5′-GCGTCCACCCGCGAGTACAA-3′ Reverse: 5′-TTGCAATGCCGGAGCCGTT-3′ Peptidylprolyl isomerase A (cyclophilin A) Ppia Forward: 5′-TTGCAGACGCCGCTGTCTCTT-3′ Reverse: 5′-TGGAACTTTGTCTGCAAACAGCTCG-3′ Quantification of glucose-induced insulin secretion

Free access

Gerald Thiel, Isabelle Müller, and Oliver G Rössler

channel activation and insulin secretion. TRPM2 is activated by H 2 O 2 and reactive oxygen species. Accordingly, TRPM2 function has been correlated with β-cell apoptosis ( Hara et al . 2002 ). TRPM2-deficient mice have higher basal glucose levels and an

Free access

Zhipeng Li, Zhaoshui Shangguan, Yijie Liu, Jihua Wang, Xuejun Li, Shuyu Yang, and Suhuan Liu

– the main form of β-cell death in the two forms of the disease ( Cnop et al . 2005 ). Current therapeutic approaches are mainly focused on increasing serum insulin levels by direct insulin administration or other agents that promote insulin secretion

Free access

Eugenio D’Amico, Hongxiang Hui, Nasif Khoury, Umberto Di Mario, and Riccardo Perfetti

impaired insulin secretion ( Patty et al. 2002 ) and β-cells apoptosis induced by the administration of immunosuppressive drugs (ISD) ( Drachenberg et al. 1999 ). For any type of immunossuppression after transplantation, a balance is sought

Free access

Magdalene O Wilson, Kathleen T Scougall, Jarupa Ratanamart, Elizabeth A McIntyre, and James A M Shaw

the muscle following plasmid injection ( Martinenghi et al. 2002 , Croze & Prud’homme 2003 ). Therapeutic applicability of this approach will be critically dependent on a mechanism for attaining regulated insulin secretion in addition to

Free access

Kay E Garnett, Philip Chapman, Julie A Chambers, Ian D Waddell, and David S W Boam

remain unknown. Chronic exposure to high glucose and elevated free fatty acid levels, observed in humans and in animal models of T2D is detrimental to β-cell function, resulting in blunted glucose-induced insulin secretion and increased levels of