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Thalijn Liliana Catharina Wolters, Mihai Gheorghe Netea, Adrianus Rudolfus Marinus Maria Hermus, Johannes Willem Adriaan Smit, and Romana Teodora Netea-Maier

. They are also known to have an increased risk of developing atherosclerosis and CVD ( Dekkers et al . 2008 ). In the last decades, abundant evidence has become available on the crucial role of inflammation in the pathogenesis of atherosclerosis

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Yeon Jean Cho, Seung Hyun Lee, Jung Woo Park, Myoungseok Han, Mi Jin Park, and Sang Jun Han

initiation and progression of endometriosis, the precise pathogenesis of endometriosis remains unknown. To help address this crucial question, we have summarized how the dysregulation of inflammation, apoptosis and oxidative stress signaling in immune cells

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Carla A Piccinato, Helena Malvezzi, Douglas A Gibson, and Philippa T K Saunders

inflammation and hormone dependence. Oestrogens acting via oestrogen receptors regulate processes including proliferation, angiogenesis, inflammation and differentiation, which are important in regulation of normal endometrium, endometrial pathologies

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William J Stanley, Prerak M Trivedi, Andrew P Sutherland, Helen E Thomas, and Esteban N Gurzov

( Moore et al . 2009 , Santin et al . 2011 ). However, the role of PTPs, other than PTPN2, in cytokine signalling regulation remained unknown. Previously, we reported that PTPN2 and PTPN6 (SHP-1) are inactivated by inflammation-dependent oxidation in

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Sarah X Zhang, Joshua J Wang, Azar Dashti, Kenneth Wilson, Ming-Hui Zou, Luke Szweda, Jian-Xing Ma, and Timothy J Lyons

Introduction Diabetic retinopathy is a common microvascular complication of diabetes and the most frequent cause of vision loss in diabetic patients ( Fong et al . 2003 ). In recent years, accumulating evidence suggests that inflammation is a key

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Jaya Nautiyal

). For example, M2 maintains homeostasis and insulin sensitivity, whereas the M1 represents a state of chronic inflammation. In a high-fat diet-induced obesity model, the number of macrophages increases from 10 to 15% of the total stromal cells, mostly in

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Choa Park, Joonwoo Park, Myeong Kuk Shim, Mee-Ra Rhyu, Byung-Koo Yoon, Kyung Sook Kim, and YoungJoo Lee

Introduction Oxygen homeostasis in blood vessels has been linked to atherosclerosis ( Sluimer et al. 2008 ). Hypoxia is a major regulator of physiological processes and diseases of chronic inflammation, including angiogenesis, glycolysis and

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María Angeles Arevalo, María Santos-Galindo, Natalia Lagunas, Iñigo Azcoitia, and Luis M Garcia-Segura

. 2009 , Mosca et al . 2009 ). Multiple sclerosis SERMs may reduce inflammation in the central nervous system (see below) and may therefore represent interesting therapeutic candidates for multiple sclerosis. Indeed, tamoxifen reduces in mice the degree

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Li Hu, Fengli He, Meifeng Huang, Meihua Peng, Zhiguang Zhou, Feng Liu, and Yan-Shan Dai

Introduction Obesity and type 2 diabetes mellitus are associated with low-grade, chronic inflammation and macrophage infiltration in adipose tissue (AT) ( Weisberg et al . 2003 , Hotamisligil 2006 , 2017 , Lumeng & Saltiel 2011

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Jonathan Pham, Kanaga Arul Nambi Rajan, Ping Li, and Mana M Parast

numerous other pathways, including those involved in cell proliferation, apoptosis, autophagy and inflammation (reviewed in Knight & Milner 2012 , Simmons et al . 2015 ). Sirt1 can be targeted by the naturally occurring compound, resveratrol, which has