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Maria Jacoba Kruger, Maria Martha Conradie, Magda Conradie, and Mari van de Vyver

Introduction Obesity-associated inflammatory mechanisms play a key role in the pathogenesis of metabolic-related diseases such as metabolic syndrome and type 2 diabetes ( Esser et al. 2014 ). Disruption of normal endocrine function affects

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Juan Liu, Xiaocen Kong, Long Wang, Hanmei Qi, Wenjuan Di, Xiao Zhang, Lin Wu, Xia Chen, Jing Yu, Juanmin Zha, Shan Lv, Aisen Zhang, Peng Cheng, Miao Hu, Yujie Li, Jianhua Bi, Yan Li, Fang Hu, Yi Zhong, Yong Xu, and Guoxian Ding

Introduction Obesity has become a global epidemic with complications substantially contributing to health care costs and mortality ( Stryjecki & Mutch 2011 ). Obesity is the condition characterized by excessive accumulation of white fat cells, which

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Charit Taneja, Sakshi Gera, Se-Min Kim, Jameel Iqbal, Tony Yuen, and Mone Zaidi

of alternate mechanism(s) of menopausal bone loss and obesity rather than the generally accepted unitary attribution to estrogen deficiency. We published the first evidence for a role of FSH in the regulation of bone mass in mice ( Sun et al. 2006

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Ting Qi, Yanming Chen, Honggui Li, Ya Pei, Shih-Lung Woo, Xin Guo, Jiajia Zhao, Xiaoxian Qian, Joseph Awika, Yuqing Huo, and Chaodong Wu

Introduction Chronic low-grade adipose tissue inflammation is a characteristic of obesity ( Lumeng et al. 2007 , Weisberg et al. 2003 , Xu et al. 2003 ) and critically contributes to the pathogenesis of type 2 diabetes ( Greenberg

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Janne Lebeck

young men fasted for 14 h ( Baba et al . 1995 ). Similarly, measurement of the amount of glycerol used for gluconeogenesis in the fasted state also demonstrates great variability and ranges from 38% in lean men after a short fast to ∼100% in obese women

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Marina R Pulido, Yoana Rabanal-Ruiz, Farid Almabouada, Alberto Díaz-Ruiz, María A Burrell, María J Vázquez, Justo P Castaño, Rhonda D Kineman, Raúl M Luque, Carlos Diéguez, Rafael Vázquez-Martínez, and María M Malagón

Zealand obese (NZO) mice and their controls, were obtained from Jackson Laboratories (Bar Harbor, ME, USA). Experimental procedures were approved by the Institutional Animal Care and Use Committee. Animals had free access to standard rodent chow and tap

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Elisa Manieri and Guadalupe Sabio

anabolic and catabolic enzymes. Whenever this coordinated regulation is lost, anabolism and catabolism become unbalanced, giving rise to metabolic disorders. Obesity, the most common metabolic disorder worldwide, develops when energy intake exceeds energy

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Martina Holubová, Lucie Hrubá, Barbora Neprašová, Zuzana Majerčíková, Zdeňka Lacinová, Jaroslav Kuneš, Lenka Maletínská, and Blanka Železná

Introduction Obesity is a common metabolic disease, but its effective noninvasive therapy remains scarce ( Bray et al . 2016 ). Several anti-obesity drugs – analogs of neurotransmitters decreasing appetite or craving for food – were withdrawn

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Yoo Mee Kim, Juan Ji An, Yong-Jun Jin, Yumie Rhee, Bong Soo Cha, Hyun Chul Lee, and Sung-Kil Lim

Introduction Obesity is highly prevalent in many developed countries and its prevalence is increasing worldwide ( Kopelman 2000 ). Diet and exercise remain the cornerstones of obesity management; however, it is likely that many

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Karen Oliva, Gillian Barker, Clyde Riley, Mark J Bailey, Michael Permezel, Gregory E Rice, and Martha Lappas

Introduction There is no disputing the extent of the worldwide obesity epidemic ( Chu et al . 2008 , Colagiuri et al . 2010 ). The proportion of women who are obese at the beginning of pregnancy has dramatically increased ( Heslehurst et al