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Andrea Armani, Vincenzo Marzolla, Andrea Fabbri, and Massimiliano Caprio

pathophysiology of obesity and metabolic syndrome. Either knockdown or pharmacological blockade of MR inhibits adipogenesis in 3T3L1 cultures ( Caprio et al . 2007 , 2011 ), revealing an important role for this transcription factor in adipose tissue physiology

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Lan Xu, Wenting Wang, Xinyue Zhang, Hanni Ke, Yingying Qin, Li You, Weiping Li, Gang Lu, Wai-Yee Chan, Peter C K Leung, Shidou Zhao, and Zi-Jiang Chen

Introduction Obesity is a global public health problem, which acts as the predominant risk factor for IR, type 2 diabetes and other metabolic disorders including hypertension and dyslipidemia ( Ozcan et al. 2004 , Stumvoll et al. 2005

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C Folgueira, S Barja-Fernandez, P Gonzalez-Saenz, V Pena-Leon, C Castelao, M Ruiz-Piñon, F F Casanueva, R Nogueiras, and L M Seoane

status of the whole organism. Such signals can be translated into feelings of satiation or hunger to regulate appetite. Satiety signals are potential targets for the design of anti-obesity drugs, which would greatly advance the fight against obesity

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Aurelie Nguyen Dinh Cat, Malou Friederich-Persson, Anna White, and Rhian M Touyz

Introduction The obesity epidemic threatens to bring with it a significant range of health problems including the increased risk of hypertension and associated cardiovascular disorders. Of note, Bambrilla and coworkers found that increased

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Ji Seon Park, Su Jung Bae, Sik-Won Choi, You Hwa Son, Sung Bum Park, Sang Dal Rhee, Hee Youn Kim, Won Hoon Jung, Seung Kyu Kang, Jin Hee Ahn, Seong Hwan Kim, and Ki Young Kim

tissue in 11β-HSD1-overexpressed mice showed metabolic syndrome-like phenotypes such as central obesity, glucose tolerance, and insulin resistance ( Masuzaki et al . 2001 , Paterson et al . 2004 ). By contrast, 11β-HSD1-deficient mice showed a

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Chunmei Wang and Yong Xu

Introduction Obesity, resulting from imbalance of energy homeostasis, is now recognized as a serious global health problem, due to its high prevalence and strong association with hypertension, coronary heart disease, stroke and other metabolic

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Rui Wang, Jie Hong, Ruixin Liu, Maopei Chen, Min Xu, Wiqiong Gu, Yifei Zhang, Qinyun Ma, Feng Wang, Juan Shi, Jiqiu Wang, Weiqing Wang, and Guang Ning

Introduction The obesity epidemic presents one of the largest worldwide threats to overall health. The elucidation of the molecular mechanisms that are involved in adipogenesis is critical to the development of effective strategies for the

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Haoyong Yu, Mingliang Zhang, Yunqin Ma, Junxi Lu, Jiemin Pan, Pan Pan, Haibing Chen, and Weiping Jia

etiologies for hepatic steatosis ( Mavrogiannaki & Migdalis 2013 ). Frequently, NAFLD clusters with metabolic abnormalities, including type 2 diabetes mellitus (T2DM), obesity, hypertension, hyperlipidemia, etc. Growing evidence has suggested that the main

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Adrian J L Clark and Li F Chan

hypothesis is provided by the development of the MRAP2 gene deleted mouse ( Mrap2−/− ), which exhibited a severe obesity phenotype ( Asai et al . 2013 ). A hypomorph Mrap2 mouse generated using a different strategy and only expressing a fraction of normal

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Li Hu, Fengli He, Meifeng Huang, Meihua Peng, Zhiguang Zhou, Feng Liu, and Yan-Shan Dai

Introduction Obesity and type 2 diabetes mellitus are associated with low-grade, chronic inflammation and macrophage infiltration in adipose tissue (AT) ( Weisberg et al . 2003 , Hotamisligil 2006 , 2017 , Lumeng & Saltiel 2011