Search Results

You are looking at 11 - 20 of 25 items for :

  • "insulin synthesis" x
  • All content x
Clear All
Free access

Julie Amyot, Isma Benterki, Ghislaine Fontés, Derek K Hagman, Mourad Ferdaoussi, Tracy Teodoro, Allen Volchuk, Érik Joly, and Vincent Poitout

stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells . PNAS 85 3865 – 3869 . doi:10.1073/pnas.85.11.3865 . Schuit FC Kiekens R Pipeleers DG 1991 Measuring the balance between insulin synthesis and insulin

Free access

Eugenio D’Amico, Hongxiang Hui, Nasif Khoury, Umberto Di Mario, and Riccardo Perfetti

GLP-1 when added to freshly isolated human islets or cultured MIN6 cells preserved cell morphology, enhanced insulin synthesis, and improved the cellular capability of secreting insulin in response to glucose ( Farilla et al. 2003 , Hui et al

Free access

Zhipeng Li, Zhaoshui Shangguan, Yijie Liu, Jihua Wang, Xuejun Li, Shuyu Yang, and Suhuan Liu

SC Le May C Dalle S Katzenellenbogen JA Katzenellenbogen BS Korach KS Mauvais-Jarvis F 2010 Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis . PNAS 107 13057 – 13062

Free access

K Alexander Iwen, Rebecca Oelkrug, and Georg Brabant

stimulation of the HPT axis, causing increases in TSH and subsequently TH levels, together with a rise in the SNS activity increases glucose production. It may be supported by positive effects of TH on insulin synthesis and release, but this effect is

Free access

Narudee Kashemsant and Catherine B Chan

change after mitochondrial uncoupling (M Collins & C Chan, unpublished data). The ATP synthase expression was similar in control and UCP2-OE cells (Fig. 3B and C ). To promote β-cell exhaustion and thereby force new insulin synthesis and

Free access

S Lortz, S Lenzen, and I Mehmeti

Kaufman RJ 2005 The mammalian unfolded protein response . Annual Review of Biochemistry 74 739 – 789 . ( doi:10.1146/annurev.biochem.73.011303.074134 ). Schuit FC Kiekens R Pipeleers DG 1991 Measuring the balance between insulin

Free access

Seisuke Sato, Hitomi Imachi, Jingya Lyu, Yumi Miyai, Kensaku Fukunaga, Tao Dong, Tomohiro Ibata, Toshihiro Kobayashi, Takuo Yoshimoto, Fumi Kikuchi, Kazuko Yonezaki, Nao Yamaji, Hisakazu Iwama, and Koji Murao

caused by TNF-α. Figure 7 Effect of tumor necrosis factor (TNF)-α on ABCA1 expression and insulin synthesis in INS-1 cells. (A) INS-1 cells were pretreated with dimethyl sulfoxide or BIRB796 (BIRB) for 30 min and then incubated with 10 ng/mL TNF

Free access

Y Y Liu, W Jia, I E Wanke, D A Muruve, H P Xiao, and N C W Wong

following exposure to glucose and then possibly hypoglycemia when insulin synthesis surpasses the needs ( Lu et al . 1998 , Olson et al . 2003 ). Physiological release of insulin is biphasic and begins with an initial surge followed by a gentle sustained

Open access

Daniela Nasteska and David J Hodson

tissue from donors. However, studies using matrix-assisted laser desorption ionisation (MALDI) imaging in fixed tissue, together with in vitro experiments, demonstrated that stearoylcarnitine accumulated in beta cells to arrest insulin synthesis, while

Free access

Jiayu Jin, Xinhong Wang, Xiuling Zhi, and Dan Meng

.1161/CIRCRESAHA.116.305510 ) You L Wang N Yin D Wang L Jin F Zhu Y Yuan Q De W 2016 Downregulation of long noncoding RNA Meg3 affects insulin synthesis and secretion in mouse pancreatic beta cells . Journal of Cellular Physiology 852