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Purificación Gómez, Francisco Pérez-Jiménez, Carmen Marín, Juan Antonio Moreno, María José Gómez, Cecilia Bellido, Pablo Pérez-Martínez, Francisco Fuentes, Juan Antonio Paniagua, and José López-Miranda

, after a 12-h fast. A continuous infusion of somatostatin (214 nmol/h), insulin (180 pmol/m 2 /min), and glucose (13.2 mmol/m 2 /min) was administered in the same vein. Somatostatin was used to inhibit endogenous insulin secretion. Blood was sampled every

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Mark C Turner, Neil R W Martin, Darren J Player, Richard A Ferguson, Patrick Wheeler, Charlotte J Green, Elizabeth C Akam, and Mark P Lewis

1994 Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man . Diabetologia 1025 – 1035 . ( ) Dietze D Koenen M Röhrig K Horikoshi H

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Daniel Raleigh, Xiaoxue Zhang, Benoît Hastoy, and Anne Clark

causative factor for type 2 diabetes. This metabolic condition involves many factors both in islets and in the periphery which contribute to the dysregulated insulin secretion; loss of β-cells and islet amyloid formation are likely to be contributory rather

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Ayse Elif Erson-Bensan

reported in ACTH-producing small cell lung cancer ( Parks et al . 1998 ). Another intronic APA event was reported for the TCF7L2 (transcription factor 7-like 2) transcript that modulates insulin secretion and is implicated in Type II diabetes. Activation

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Heather C Denroche and C Bruce Verchere

ratio of IAPP:insulin secretion or expression may increase in states of beta cell dysfunction ( O’Brien et al . 1991 , Pieber et al . 1993 , Hiramatsu et al . 1994 , Mulder et al . 1995 a , 1996 , Ahrén & Gutniak 1997 , Hull et al . 2004

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Young Ho Suh, Younyoung Kim, Jeong Hyun Bang, Kyoung Suk Choi, June Woo Lee, Won-Ho Kim, Tae Jeong Oh, Sungwhan An, and Myeong Ho Jung

insulin secretion and the effects of insulin on its target tissues by inhibition of IR tyrosine phosphorylation ( Melki et al. 1994 ). Furthermore, it was reported that the annexin 1 gene harbors variants that increase the risk of type 2 diabetes

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Paul de Goede, Jakob Wefers, Eline Constance Brombacher, Patrick Schrauwen, and Andries Kalsbeek

gradient and thus to a decrease in the ATP/ADP ratio ( Lee et al . 2011 ). Since the ATP/ADP ratio is an important cue for insulin secretion, this observation may link the molecular circadian clock machinery via mitochondrial respiration to insulin

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Hyon-Seung Yi, Joon Young Chang, and Minho Shong

mitochondrial membrane, in beta cells triggers progressive failure of insulin secretion and cellular proliferation ( Kim et al . 2015 ). Beta-cell-specific knockout of Tfam , a transcription factor of mtDNA-encoded OxPhos polypeptides, promotes hyperglycemia

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Shannon E Mullican, Joanna R DiSpirito, and Mitchell A Lazar

Myeloid: autoimmunity; glycemic control (HFD) Skeletal muscle: glycemic control; fiber type; regeneration Pancreas: insulin secretion Heart (transgene): glycemic control PPARγ (NR1C3) Yes KO: death by E10.5 (placentation) KI (hypomorphic): premature death

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David R Clemmons

physiologic insulin secretion leads to an increase in IGFBP1, which inhibits adipogenesis ( Wheatcroft & Kearney 2009 ). A specific receptor that is mediating these effects has not been identified, and they are presumed to be mediated only by changes in IGF1