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Rhonda D Kineman, Mercedes del Rio-Moreno, and André Sarmento-Cabral

/testosterone) Glucocorticoids, derived from the adrenal cortex, stimulate glucose production in the liver, antagonize the actions of insulin and decrease insulin secretion from the pancreatic β-cells ( Whirledge & DeFranco 2018 ). Glucocorticoid receptors (GRs) physically

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Giulia Cantini, Martina Trabucco, Alessandra Di Franco, Edoardo Mannucci, and Michaela Luconi

GLP-1R has been recently demonstrated in pancreatic beta-cells; in these cells, in conditions of high glucose, glucagon can stimulate insulin secretion through a specific binding to beta-cell GLP-1R ( Svendsen et al. 2018 ). As mentioned earlier

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Yu-Guang Ma, Liang Liang, Yin-Bin Zhang, Bao-Feng Wang, Yun-Gang Bai, Zhi-Jun Dai, Man-Jiang Xie, and Zhong-Wei Wang

and the reduction in insulin secretion capacity ( Zhang et al . 2008 ). Vascular disease is one of the important factors for the increased risks of stroke, heart attack and organ damage in diabetic patients ( Fernández-Velasco et al . 2014

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Gilberto Paz-Filho, Claudio Alberto Mastronardi, Brian J Parker, Ainy Khan, Antonio Inserra, Klaus I Matthaei, Monika Ehrhart-Bornstein, Stefan Bornstein, Ma-Li Wong, and Julio Licinio

in the same direction (Adjusted P value <0.10) of the following pathways: i) motifs corresponding to the GABP TF; ii) miR-124A; and iii) glucose regulation of insulin secretion. No pathway was significantly upregulated in the same direction. The

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A Stevens, C De Leonibus, D Hanson, A W Dowsey, A Whatmore, S Meyer, R P Donn, P Chatelain, I Banerjee, K E Cosgrove, P E Clayton, and M J Dunne

, excess insulin secretion from pancreatic β-cells, which manifests as profound hypoglycaemia ( De Leon & Stanley 2007 , Banerjee et al . 2013 ). CHI is the commonest cause of persistent hypoglycaemia in infancy. In contrast to other causes of

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Ana Luísa Neves, João Coelho, Luciana Couto, Adelino Leite-Moreira, and Roberto Roncon-Albuquerque Jr

prebiotics, Bifidobacterium spp. is positively correlated with an improved glucose tolerance, glucose-induced insulin secretion, and normalized inflammatory tone, decreasing endotoxemia, plasma, and adipose tissue proinflammatory cytokines Prebiotic

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Kazuyoshi Ukena, Tomohiro Osugi, Jérôme Leprince, Hubert Vaudry, and Kazuyoshi Tsutsui

human adrenocortical cells ( Ramanjaneya et al . 2013 ). In the rat pancreas, glucose-evoked insulin secretion is reduced by perfusion of 26RFa/QRFP ( Egido et al . 2007 ). In the adipocyte cell line 3T3-L1, 26RFa/QRFP inhibits isoproterenol

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Suzuka Onishi and Kohsuke Kataoka

Shibasaki Y Oka Y Yamamura KI 1990 Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms . Endocrinology 126 – 132 . (

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Ying Ying, Huazhang Zhu, Zhen Liang, Xiaosong Ma, and Shiwei Li

of palmitate-induced cardiomyocyte apoptosis has not been determined thus far. Glucagon-like peptide 1 (GLP1) is an incretin hormone synthesized and secreted by intestinal L-cells and stimulates insulin secretion from pancreatic b-cells in a glucose

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Purificación Gómez, Francisco Pérez-Jiménez, Carmen Marín, Juan Antonio Moreno, María José Gómez, Cecilia Bellido, Pablo Pérez-Martínez, Francisco Fuentes, Juan Antonio Paniagua, and José López-Miranda

, after a 12-h fast. A continuous infusion of somatostatin (214 nmol/h), insulin (180 pmol/m 2 /min), and glucose (13.2 mmol/m 2 /min) was administered in the same vein. Somatostatin was used to inhibit endogenous insulin secretion. Blood was sampled every