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A Stevens, C De Leonibus, D Hanson, A W Dowsey, A Whatmore, S Meyer, R P Donn, P Chatelain, I Banerjee, K E Cosgrove, P E Clayton, and M J Dunne

, excess insulin secretion from pancreatic β-cells, which manifests as profound hypoglycaemia ( De Leon & Stanley 2007 , Banerjee et al . 2013 ). CHI is the commonest cause of persistent hypoglycaemia in infancy. In contrast to other causes of

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Endong Zhu, Juanjuan Zhang, Jie Zhou, Hairui Yuan, Wei Zhao, and Baoli Wang

( Banerjee et al . 2003 ). Overexpressing KLF7 decreases the differentiation of the human preadipocyte and inhibits glucose-induced insulin secretion in pancreatic β-cell line ( Kawamura et al . 2006 ). Sue and coworkers reported that (I) the mRNA level of

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Giulia Cantini, Martina Trabucco, Alessandra Di Franco, Edoardo Mannucci, and Michaela Luconi

GLP-1R has been recently demonstrated in pancreatic beta-cells; in these cells, in conditions of high glucose, glucagon can stimulate insulin secretion through a specific binding to beta-cell GLP-1R ( Svendsen et al. 2018 ). As mentioned earlier

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Changxue Lu and Sheue-Yann Cheng

( Jatwa et al . 2007 ). Moreover, in rats with a high-fat diet and in a hyperthyroid state, administration of the PPARα agonist Wy14,643 restores glucose tolerance by enhancing glucose-stimulated insulin secretion and relieves the effect of

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Ana Luísa Neves, João Coelho, Luciana Couto, Adelino Leite-Moreira, and Roberto Roncon-Albuquerque Jr

prebiotics, Bifidobacterium spp. is positively correlated with an improved glucose tolerance, glucose-induced insulin secretion, and normalized inflammatory tone, decreasing endotoxemia, plasma, and adipose tissue proinflammatory cytokines Prebiotic

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Kazuyoshi Ukena, Tomohiro Osugi, Jérôme Leprince, Hubert Vaudry, and Kazuyoshi Tsutsui

human adrenocortical cells ( Ramanjaneya et al . 2013 ). In the rat pancreas, glucose-evoked insulin secretion is reduced by perfusion of 26RFa/QRFP ( Egido et al . 2007 ). In the adipocyte cell line 3T3-L1, 26RFa/QRFP inhibits isoproterenol

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Ying Ying, Huazhang Zhu, Zhen Liang, Xiaosong Ma, and Shiwei Li

of palmitate-induced cardiomyocyte apoptosis has not been determined thus far. Glucagon-like peptide 1 (GLP1) is an incretin hormone synthesized and secreted by intestinal L-cells and stimulates insulin secretion from pancreatic b-cells in a glucose

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Suzuka Onishi and Kohsuke Kataoka

Shibasaki Y Oka Y Yamamura KI 1990 Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms . Endocrinology 126 – 132 . (

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Sachie Nakamichi, Yoko Senga, Hiroshi Inoue, Aki Emi, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Wataru Ogawa, and Masato Kasuga

glucose intolerance induced by hepatic GRAIL deficiency was likely attributable not to a defect in insulin secretion but to impairment of insulin sensitivity. The dysregulation of hepatic glucose production is an important pathological feature of type 2

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Purificación Gómez, Francisco Pérez-Jiménez, Carmen Marín, Juan Antonio Moreno, María José Gómez, Cecilia Bellido, Pablo Pérez-Martínez, Francisco Fuentes, Juan Antonio Paniagua, and José López-Miranda

, after a 12-h fast. A continuous infusion of somatostatin (214 nmol/h), insulin (180 pmol/m 2 /min), and glucose (13.2 mmol/m 2 /min) was administered in the same vein. Somatostatin was used to inhibit endogenous insulin secretion. Blood was sampled every