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L Y Ching, Bonnie H Y Yeung, and Chris K C Wong

inflammation and carcinogenesis ( Wagner et al . 1997 , Madsen et al . 1998 , Chang et al . 2003 , Yoshiko & Aubin 2004 , Ellard et al . 2007 , Re & Cook 2010 , Sheikh-Hamad 2010 ). Cancer has been considered as a chronic inflammatory disease ( Lopez

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Chunyu Wang, Li Tian, Kun Zhang, Yaxi Chen, Xiang Chen, Ying Xie, Qian Zhao, and Xijie Yu

secretion, such as leptin and adiponectin, which might exert a direct effect on bone formation or indirect effect on bone resorption. Furthermore, obesity is related to a chronic inflammation condition. Increase in circulating and tissue proinflammatory

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Qin He, Dan Mei, Sha Sha, Shanshan Fan, Lin Wang, and Ming Dong

isoquinoline alkaloid isolated from Berberis vulgaris L, has been widely used in traditional Chinese medicine to treat diarrhoea, insulin resistance, inflammation and gastrointestinal disorders. Recently, there is fast-growing concerns in exploring its

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Andrea Armani, Vincenzo Marzolla, Andrea Fabbri, and Massimiliano Caprio

pathophysiological contexts, including metabolic syndrome, oxidative stress, stress adaptability, inflammation and more. In this context, several research groups identified the adipocyte as a novel cellular model for investigating the function of MR in the

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Zhao Yang, Zhi-Li Huang, and Ya-Xiong Tao

cardiovascular function ( Versteeg et al . 1998 , Mioni et al . 2003 ), natriuresis ( Ni et al . 2006 , Chandramohan et al . 2009 ), and inflammation ( Catania et al . 2004 , Getting et al . 2006 , Getting et al . 2008 ). The MC3R, together with MC4R

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Lai Jin, Chuanhua Li, Rong Li, Zongxing Sun, Xianjun Fang, and Shengnan Li

mediators including TNFα and IL1β are natural stimulators of cPLA 2 gene expression ( Dolan-O'Keefe et al . 2000 ). CRH family peptides are closely associated with inflammation ( Webster et al . 1998 ). In order to investigate whether CRH family peptides

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Ashley A Able, Allison J Richard, and Jacqueline M Stephens

protein 1 (MCP1) and tumor necrosis factor-alpha (TNFα), indicating that DBC1 may influence adipocyte inflammation ( Moreno-Navarrete et al. 2015 b ). DBC1 has also been implicated in senescence of preadipocytes as loss of DBC1 protects again cellular

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Michael Welsh, Maria Jamalpour, Guangxiang Zang, and Björn Åkerblom

detected as selectively present in focal adhesions ( Winograd-Katz et al . 2014 ). SHB and inflammation A characteristic feature of SHB based on data obtained from the Shb knockout mouse is its involvement in inflammatory processes ( Arbiser 2015 ). An

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Isabel Castro, Leah Quisenberry, Rosa-Maria Calvo, Maria-Jesus Obregon, and Joaquin Lado-Abeal

responsible for the decrease in TH receptor β1 ( THRB1 ) expression during inflammation in rodents ( Kwakkel et al . 2006 ). Limited access to human tissues is an obstacle for understanding the effects of NTIS on patients and uncovering the molecular

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Marc Simard, Caroline Underhill, and Geoffrey L Hammond

thought to promote the delivery of cortisol to sites of inflammation ( Hammond et al . 1990 , Lin et al . 2009 ). A metalloprotease (LasB), secreted by the pathogen Pseudomonas aeruginosa, may also contribute to the localized release of cortisol from