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Rihua Zhang, Dongming Su, Weidong Zhu, Qiong Huang, Menglan Liu, Yi Xue, Yuanyuan Zhang, Dong li, Allan Zhao, and Yun Liu

models have shown that oophorectomy results in obesity, altered fat distribution, adipose tissue inflammation, and development of fatty liver ( Rogers et al . 2009 , Stubbins et al . 2012 ). Estrogen therapy is believed to have beneficial effects on

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Juan Liu, Xiaocen Kong, Long Wang, Hanmei Qi, Wenjuan Di, Xiao Zhang, Lin Wu, Xia Chen, Jing Yu, Juanmin Zha, Shan Lv, Aisen Zhang, Peng Cheng, Miao Hu, Yujie Li, Jianhua Bi, Yan Li, Fang Hu, Yi Zhong, Yong Xu, and Guoxian Ding

, Staab & Maser 2010 ). Besides, we recently found that BVT.2733, a selective 11β-HSD1 inhibitor, could even attenuate the inflammation of WAT in diet-induced obese mice ( Wang et al . 2012 ). However, the role of 11β-HSD1 in BAT remains largely unknown

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Chunyu Wang, Li Tian, Kun Zhang, Yaxi Chen, Xiang Chen, Ying Xie, Qian Zhao, and Xijie Yu

secretion, such as leptin and adiponectin, which might exert a direct effect on bone formation or indirect effect on bone resorption. Furthermore, obesity is related to a chronic inflammation condition. Increase in circulating and tissue proinflammatory

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L Y Ching, Bonnie H Y Yeung, and Chris K C Wong

inflammation and carcinogenesis ( Wagner et al . 1997 , Madsen et al . 1998 , Chang et al . 2003 , Yoshiko & Aubin 2004 , Ellard et al . 2007 , Re & Cook 2010 , Sheikh-Hamad 2010 ). Cancer has been considered as a chronic inflammatory disease ( Lopez

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Qin He, Dan Mei, Sha Sha, Shanshan Fan, Lin Wang, and Ming Dong

isoquinoline alkaloid isolated from Berberis vulgaris L, has been widely used in traditional Chinese medicine to treat diarrhoea, insulin resistance, inflammation and gastrointestinal disorders. Recently, there is fast-growing concerns in exploring its

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Marc Simard, Caroline Underhill, and Geoffrey L Hammond

thought to promote the delivery of cortisol to sites of inflammation ( Hammond et al . 1990 , Lin et al . 2009 ). A metalloprotease (LasB), secreted by the pathogen Pseudomonas aeruginosa, may also contribute to the localized release of cortisol from

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Ashley A Able, Allison J Richard, and Jacqueline M Stephens

protein 1 (MCP1) and tumor necrosis factor-alpha (TNFα), indicating that DBC1 may influence adipocyte inflammation ( Moreno-Navarrete et al. 2015 b ). DBC1 has also been implicated in senescence of preadipocytes as loss of DBC1 protects again cellular

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Michael Welsh, Maria Jamalpour, Guangxiang Zang, and Björn Åkerblom

detected as selectively present in focal adhesions ( Winograd-Katz et al . 2014 ). SHB and inflammation A characteristic feature of SHB based on data obtained from the Shb knockout mouse is its involvement in inflammatory processes ( Arbiser 2015 ). An

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Ying Chen, Hua Ni, Xing-Hong Ma, Shi-Jun Hu, Li-Ming Luan, Gang Ren, Yue-Chao Zhao, Shi-Jie Li, Hong-Lu Diao, Xiu Xu, Zhen-Ao Zhao, and Zeng-Ming Yang

-implantation site on day 5 of pregnancy (Fig. 3K ), and on day 5 of pseudopregnancy (Fig. 3L ). T-cell immunoglobulin and mucin domain containing 2 ( Timd2 ) is critical for the regulation of Th2 responses during autoimmune inflammation ( Chakravarti et al. 2005

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Andrea Armani, Vincenzo Marzolla, Andrea Fabbri, and Massimiliano Caprio

pathophysiological contexts, including metabolic syndrome, oxidative stress, stress adaptability, inflammation and more. In this context, several research groups identified the adipocyte as a novel cellular model for investigating the function of MR in the