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William J Stanley, Prerak M Trivedi, Andrew P Sutherland, Helen E Thomas, and Esteban N Gurzov

.10.004 ) 10.1016/j.tem.2014.10.004 Gurzov EN Stanley WJ Pappas EG Thomas HE Gough DJ 2016 The JAK/STAT pathway in obesity and diabetes . FEBS Journal 283 3002 – 3015 . ( doi:10.1111/febs.13709 ) 10.1111/febs.13709 Hamilton

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Jong-Ik Hwang, Seongsik Yun, Mi Jin Moon, Cho Rong Park, and Jae Young Seong

on type 2 diabetes and obesity, molecular interaction with its receptor is not fully understood. Particularly, the specific amino acid residues within the TMH and ECL of receptors that may confer ligand binding and receptor activation remain poorly

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Carolin L Piechowski, Anne Rediger, Christina Lagemann, Jessica Mühlhaus, Anne Müller, Juliane Pratzka, Patrick Tarnow, Annette Grüters, Heiko Krude, Gunnar Kleinau, and Heike Biebermann

food intake and increased energy expenditure ( Cone 2006 ). From in vitro studies, it is known that MC4R exhibits ligand-independent activity ( Nijenhuis et al . 2001 ). Heterozygous MC4R mutation is the most frequent known genetic cause of obesity

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Ilaria Cimmino, Francesco Oriente, Vittoria D’Esposito, Domenico Liguoro, Pasquale Liguoro, Maria Rosaria Ambrosio, Serena Cabaro, Francesco D’Andrea, Francesco Beguinot, Pietro Formisano, and Rossella Valentino

in vitro and in vivo studies have reported adverse effects of BPA, as well as its association with inflammation, obesity and impaired metabolism also at nanomolar concentrations ( Welshons et al. 2006 , Hugo et al. 2008 , Rubin 2011

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Angela Nebbioso, Carmela Dell'Aversana, Anne Bugge, Roberta Sarno, Sergio Valente, Dante Rotili, Fabio Manzo, Diana Teti, Susanne Mandrup, Paolo Ciana, Adriana Maggi, Antonello Mai, Hinrich Gronemeyer, and Lucia Altucci

effect of the drug was assessed in the PPRE-Luc PPAR reporter mouse model in vivo with the idea of exploring a possible anti-obesity activity. In this reporter, mouse luciferase expression is activated in response to PPAR agonists in cognate target

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Kjersti M Aagaard-Tillery, Kevin Grove, Jacalyn Bishop, Xingrao Ke, Qi Fu, Robert McKnight, and Robert H Lane

understanding of the role of epigenetic modifications as they relate to models of IUGR, a paucity of information exists regarding these events in relation to maternal obesity. The current global health epidemic of obesity is considered a major contributor to the

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Kayla A Boortz, Kristen E Syring, Lynley D Pound, Huan Mo, Lisa Bastarache, James K Oeser, Owen P McGuinness, Joshua C Denny, and Richard M O’Brien

influences the effect of G6pc2 deletion on body weight and the response to diet-induced obesity (DIO). The results show that the effect of G6pc2 deletion on FBG is largely independent of gender, genetic background and diet, whereas the effect of G6pc2

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Xiaoting Jiang, Xin Ye, Wei Guo, Hongyun Lu, and Zhanguo Gao

( Gao et al . 2006 ) and prevented high-fat-diet-induced obesity (DIO) in mice ( Gao et al . 2009 ). HDAC3, a member of the class I HDACs, has been reported by our and other laboratories to regulate PPARγ function in adipocytes ( Fajas et al . 2002

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Michael E Baker and Gary Hardiman

– 2930 . ( doi:10.1016/j.molimm.2009.07.002 ). Heindel JJ vom Saal FS 2009 Role of nutrition and environmental endocrine disrupting chemicals during the perinatal period on the aetiology of obesity . Molecular and Cellular Endocrinology 304

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Raul M Luque, Manuel D Gahete, Rudy J Valentine, and Rhonda D Kineman

al. 1988 , Mercado & Baumann 1995 , Scacchi et al. 2003 ), while basal and stimulated GH release is suppressed in obesity ( Maccario et al. 1994 , Scacchi et al. 1999 , Weltman et al. 2001 ). Several hypotheses have been put forward