Search Results

You are looking at 131 - 140 of 249 items for :

  • "insulin secretion" x
  • All content x
Clear All
Free access

Guojun Shi, Chen Sun, Weiqiong Gu, Minglan Yang, Xiaofang Zhang, Nan Zhai, Yan Lu, Zhijian Zhang, Peishun Shou, Zhiguo Zhang, and Guang Ning

patients and their insulin secretion. Figure 1 FFAR2 expression is elevated in the peripheral blood mononuclear cells (PBMCs) of type 1 diabetes (T1D) patients. (A) Relative FFAR2 mRNA expression in PBMCs of patients with recent-onset T1D ( n =33) and

Free access

Lykke Blaabjerg, Gitte L Christensen, Masahito Matsumoto, Talitha van der Meulen, Mark O Huising, Nils Billestrup, and Wylie W Vale

activates adenylate cyclase to stimulate cAMP production. We have previously shown that CRFR1 activation increases insulin secretion from the pancreatic islets ( Huising et al . 2010 ). The signaling induced by GIP and GLP1 is known to prevent cytokine

Free access

A T Suckow, I R Sweet, B Van Yserloo, E A Rutledge, T R Hall, M Waldrop, and S D Chessler

. 2002 ). Using an insulin ELISA (Crystal Chem. Inc., Downers Grove, IL, USA), we have periodically evaluated glucose-stimulated insulin secretion using static culture and similarly determined that the cells had maintained glucose responsiveness (data

Free access

Elisa Manieri and Guadalupe Sabio

very elegant recent study showed that p38δ controls insulin secretion through the phosphorylation and inhibition of polycystic kidney disease 1 protein (PKD1) ( Sumara et al . 2009 ). PKD1 regulates insulin secretion and cell survival, and mice lacking

Free access

Tarlliza R Nardelli, Emerielle C Vanzela, Keli C Benedicto, Flora Brozzi, André Fujita, Alessandra K Cardozo, Décio L Eizirik, Antonio C Boschero, and Fernanda Ortis

Introduction Type 1 diabetes (T1D) is caused by an autoimmune assault that induces progressive beta-cell dysfunction and apoptosis, consequently impairing insulin secretion. During insulitis, pro-inflammatory cytokines such as interleukin 1

Free access

H Wang, Y Horikawa, L Jin, T Narita, S Yamada, N Shihara, K Tatemoto, M Muramatsu, T Mune, and J Takeda

at various levels in many tissues. Receptors of the insulin/insulin-like growth factor (IGF) family have been implicated both in the regulation of pancreatic β-cell growth and insulin secretion. IRR, an orphan receptor of the insulin receptor

Free access

Abby F Fleisch, Robert O Wright, and Andrea A Baccarelli

developed glucose intolerance, impaired insulin secretion, and decreased pancreatic islet and β-cell mass compared with control offspring. Il13ra2 , part of the Jak–Stat signaling pathway, was hypomethylated and upregulated in HFD offspring, suggesting that

Free access

Andreas Petri, Jonas Ahnfelt-Rønne, Klaus Stensgaard Frederiksen, David George Edwards, Dennis Madsen, Palle Serup, Jan Fleckner, and R Scott Heller

tetrahydrobiopterin synthesis precedes nitric oxide-dependent inhibition of insulin secretion ( Laffranchi et al. 1997 ). The terms that are associated with the largest number of genes showing reduced expression at e13 are related to apoptosis. Interestingly, genes

Free access

Kira Meyerovich, Fernanda Ortis, Florent Allagnat, and Alessandra K Cardozo

to sense blood glucose and to respond to changeable demands in insulin secretion. An increase in insulin production, up to 20-fold induced by glucose, is a common physiological response of β-cells that results in an intense trafficking of proteins

Free access

Lena Espelage, Hadi Al-Hasani, and Alexandra Chadt

alterations in energy demand. In the healthy state, postprandial insulin secretion leads to enhanced glucose oxidation, while lipid oxidation is inhibited ( Chomentowski et al. 2011 ). Conversely, the insulin-resistant state is mostly characterized by