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C Folgueira, S Barja-Fernandez, P Gonzalez-Saenz, V Pena-Leon, C Castelao, M Ruiz-Piñon, F F Casanueva, R Nogueiras, and L M Seoane

associated with endoplasmic reticulum (ER) stress ( Kim et al . 2016 ). In line with this observation, a recent study has found that inflammation correlates with decreased circulating proUGN levels female adolescents with obesity ( Di Guglielmo et al . 2017

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Dawn X Zhang and Christopher K Glass

immunity and normal homeostatic processes, macrophages are essential to the body's ability to control inflammation. Consequently, these immune cells have been implicated in multiple disease processes such as diabetes, rheumatoid arthritis, multiple

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Z Alourfi, R P Donn, A Stevens, A Berry, A McMaster, and D W Ray

immunoreactivity has also been described within sites of inflammation including those of inflammatory arthritis, colitis and psoriatic skin lesions (reviewed by ( Nishihira 1998 , Lue et al. 2002 ). A direct role for MIF in the aetiology of the inflammatory

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Guoqing Lei, Linxi Chen, Miao Peng, Bolin Zeng, Qiaoxi Yang, Hening Zhai, and Geyang Xu

, Blahoianu et al. 2014 ). IL-27 inhibits streptozotocin (STZ)-induced hyperglycemia and pancreatic islet inflammation in type 1 diabetic mice ( Fujimoto et al. 2011 ). Toll-like receptor-induced secretion of IL-27 is defective in newly diagnosed type-2

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Jerzy-Roch Nofer

permanent hyperlipidemic state, which favors penetration of pro-atherogenic lipoproteins into the arterial wall and produces chronic inflammation accompanied by monocytosis promoting the recruitment of monocytes into the vessel wall. While a cholesterol

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Kun Chen, Ji-Dan Zhou, Feng Zhang, Fang Zhang, Rui-Rui Zhang, Meng-Si Zhan, Xiao-Yin Tang, Bing Deng, Ming-Gang Lei, and Yuan-Zhu Xiong

studies showed that GPR120 has been shown to play an important role in various physiological processes such as lipogenesis, inflammation, adipogenesis, and glucose intolerance ( Gotoh et al . 2007 , Tanaka et al . 2008 , Oh et al . 2010 , Ichimura

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Kent Wehmeier, Luisa M Onstead-Haas, Norman C W Wong, Arshag D Mooradian, and Michael J Haas

decreased insulin action in skeletal muscle and liver in hyperinsulinemic-euglycemic clamp studies ( Kim et al. 2004 ), IL-6-deficient mice displayed hyperleptinemia and hyperinsulinemia, liver inflammation, and steatohepatitis ( Wallenius et al. 2002

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Melanie Sapochnik, Mariana Fuertes, and Eduardo Arzt

Introduction Cytokines perform essential roles during infection, cancer and inflammation where they regulate cellular proliferation, differentiation and survival or death ( Dranoff 2004 , Dinarello 2007 ). In particular, interleukin 6 (IL-6

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Jessica Sabourin and Florent Allagnat

variety of cell functions such as proliferation, growth, migration, inflammation and apoptosis. In addition, SOCE has been proposed to contribute to short-term cellular responses such as Ca 2+ oscillations, exocytosis and muscle contractility. Despite the

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Robert Lee Stanley, Takako Ohashi, Jacob Gordon, and Chishimba Nathan Mowa

capacity of neutrophils and macrophages during inflammation and wound healing ( Witke et al . 1996 ). Also, gelsolin has been clinically associated with a variety of impairments in inflammation, cell invasion, immune cell recruitment and wound healing