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Cyrus C Martin, Brian P Flemming, Yingda Wang, James K Oeser, and Richard M O'Brien

glucokinase could create a substrate cycle and therefore modulate β cell glycolytic flux and glucose-stimulated insulin secretion ( Newgard et al . 2002 ). Indeed, recent genetic data also suggest that variations in IGRP expression and/or activity are linked

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Guoqing Lei, Linxi Chen, Miao Peng, Bolin Zeng, Qiaoxi Yang, Hening Zhai, and Geyang Xu

(7-36) amide form, with a lesser amount of the bioactive GLP-1(7-37) form also detectable ( Kreymann et al. 1987 ). The biological activities of GLP-1 include stimulation of glucose-dependent insulin secretion and insulin biosynthesis, inhibition of glucagon

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Xilin Yang, Zezhang Tao, Zhanyong Zhu, Hua Liao, Yueqiang Zhao, and Huajun Fan

sequences with partial complementarity in the 3′-untranslated regions (3′-UTRs) of mRNAs, resulting in mRNA degradation ( Lai 2002 , Krol et al . 2010 ). A number of miRNAs have been shown to regulate insulin secretion. For example, miR-184 inhibits

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Afreen Idris Shariff, Sohail Syed, Rebecca A Shelby, Jeremy Force, Jeffrey Melson Clarke, David D’Alessio, and Leonor Corsino

signaling pathway is a key pathway utilized by cancer cells to promote cellular proliferation, growth and angiogenesis. Thus, some new drugs that target the insulin signaling pathway carry a risk for causing insulin resistance, impaired insulin secretion or

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Ciro Menale, Maria Teresa Piccolo, Grazia Cirillo, Raffaele A Calogero, Alfonso Papparella, Luigi Mita, Emanuele Miraglia Del Giudice, Nadia Diano, Stefania Crispi, and Damiano Gustavo Mita

100 μg/ml streptomycin. PANC-1 cells were cultured in high-glucose medium (4.5 g/l) to stimulate insulin secretion. Cells were expanded up to passage X before use. Cells were grown in a humidified atmosphere containing 5% CO 2 at 37 °C. Cells that had

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Carlos Gaspar, Jonás I Silva-Marrero, María C Salgado, Isabel V Baanante, and Isidoro Metón

detoxification in the liver, acid excretion by providing urinary ammonia in the kidneys, amplification of glucose-stimulated insulin secretion in pancreatic β-cells, cycling of the neurotransmitter glutamate between neurons and astrocytes and gluthatione

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Zodwa Dlamini, Fortunate Mokoena, and Rodney Hull

) ( Vandiedonck et al . 2011 ). Type 2 diabetes is characterised by insulin resistance, defective insulin secretion, β-cell apoptosis and islet amyloid deposits ( Table 1 ). Amyloid deposits consist of islet amyloid polypeptide (IAPP) which is secreted from β

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Rihua Zhang, Dongming Su, Weidong Zhu, Qiong Huang, Menglan Liu, Yi Xue, Yuanyuan Zhang, Dong li, Allan Zhao, and Yun Liu

with E 2 was higher than physiological concentrations at 120 min (32.2±2.2 vs 6.1±1.1 mM; Fig. 2A ). The OVX rats had already become glucose-intolerant at this time. When compared with control rats, glucose-stimulated insulin secretion was abolished

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Shinobu Shimizu, Tetsuya Hosooka, Tomokazu Matsuda, Shun-ichiro Asahara, Maki Koyanagi-Kimura, Ayumi Kanno, Alberto Bartolome, Hiroaki Etoh, Megumi Fuchita, Kyoko Teruyama, Hiroaki Takahashi, Hiroyuki Inoue, Yusuke Mieda, Naoko Hashimoto, Susumu Seino, and Yoshiaki Kido

that can be used for the treatment of type 2 diabetes. These agents act by increasing the incretin hormone glucagon-like peptide-1 (GLP1), which stimulates insulin secretion ( Holst & Deacon 2004 ). In addition to this action, GLP1 and its analogs have

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R Buettner, K G Parhofer, M Woenckhaus, C E Wrede, L A Kunz-Schughart, J Schölmerich, and L C Bollheimer

the column than short-chain fatty acids or unsaturated fatty acids. Internal standards are used for identification and quantification. Insulin secretion analysis from pancreatic islets ex vivo Pancreatic islets were