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Elisa Manieri and Guadalupe Sabio

secretion of adipokines ( Gavrilova et al . 2000 ). In the obese state, adipocyte enlargement induces molecular and cellular alterations that affect whole-body metabolic homeostasis. Increased lipolysis in adipocytes leads to increased hyperlipidaemia and

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Fumihiko Hakuno and Shin-Ichiro Takahashi

, lipolysis and protein degradation. IGFs predominantly mediate long-term action to determine the cell fates, whereas insulin mainly possesses metabolic activity. Despite the profuseness and diversity of these effects of IGFs, the in vitro biological

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Young Ho Suh, Younyoung Kim, Jeong Hyun Bang, Kyoung Suk Choi, June Woo Lee, Won-Ho Kim, Tae Jeong Oh, Sungwhan An, and Myeong Ho Jung

insulin to stimulate muscle glucose uptake and to inhibit hepatic glucose production ( Lewis et al. 2002 ). Lipolysis in adipose tissue is mediated, in part, via interaction of fatty acid binding protein (FABP) with hormone sensitive lipase ( Lewis et

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Weiwei Fan, Annette R Atkins, Ruth T Yu, Michael Downes, and Ronald M Evans

Journal 27 4004 – 4016 . ( doi:10.1096/fj.13-228296 ). Maxwell MA Cleasby ME Harding A Stark A Cooney GJ Muscat GE 2005 Nur77 regulates lipolysis in skeletal muscle cells – evidence for cross-talk between the β-adrenergic and an orphan

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Shambhunath Bose, M Abul Farah, Ho-Chul Jung, Jeong-Heon Lee, and Yangsun Kim

oxidation, glycogen synthesis, and lipogenesis in addition to the inhibition of lipolysis and gluconeogenesis (reviewed by Srivastava & Mehdi 2005 ). Cumulative reports suggest that vanadium can trigger the activation of many components of insulin signaling

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Zhigang Hu, Wen-Jun Shen, Fredric B Kraemer, and Salman Azhar

Kraemer FB 2001 Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway . Journal of Biological Chemistry 276 45456 – 45461 . ( doi:10.1074/jbc.M104436200 ) 10.1074/jbc.M104436200 Hiort O

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Raghunath Chatterjee, Paramita Bhattacharya, Oksana Gavrilova, Kimberly Glass, Jaideep Moitra, Max Myakishev, Stephanie Pack, William Jou, Lionel Feigenbaum, Michael Eckhaus, and Charles Vinson

thermogenic capacity of the aP2-A-C/EBP male mice, we stimulated them with the β3-adrenergic agonist, CL316243, which induces lipolysis in WAT and thermogenesis in BAT ( Himms-Hagen et al . 1994 ). In response to CL316243, the wild-type mice doubled their

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Chunmei Wang and Yong Xu

Spranger J Foryst-Ludwig A Kintscher U 2012 Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis . PLoS ONE 7 e37794 . ( https://doi.org/10.1371/journal.pone.0037794 ) Berglund ED Liu C Sohn JW Liu T Kim MH Lee CE

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Cristina Velasco, Cristina Otero-Rodiño, Sara Comesaña, Jesús M Míguez, and José L Soengas

-inhibited adipocyte lipolysis . Comparative Biochemistry and Physiology A 204 76 – 84 . ( doi:10.1016/j.cbpa.2016.11.011 ) 10.1016/j.cbpa.2016.11.011 Tang Z Sun C Yan A Wu S Qin C Zhang Y Li W 2013 Genes involved in fatty acid

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Dimitrios Doultsinos and Ian Mills

Teesch LM , 2017 ER stress inhibits liver fatty acid oxidation while unmitigated stress leads to anorexia-induced lipolysis and both liver and kidney steatosis . Cell Reports 19 1794 – 1806 . ( https://doi.org/10.1016/j.celrep.2017