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Elisa Manieri and Guadalupe Sabio

secretion of adipokines ( Gavrilova et al . 2000 ). In the obese state, adipocyte enlargement induces molecular and cellular alterations that affect whole-body metabolic homeostasis. Increased lipolysis in adipocytes leads to increased hyperlipidaemia and

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Fumihiko Hakuno and Shin-Ichiro Takahashi

, lipolysis and protein degradation. IGFs predominantly mediate long-term action to determine the cell fates, whereas insulin mainly possesses metabolic activity. Despite the profuseness and diversity of these effects of IGFs, the in vitro biological

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Cristina Velasco, Cristina Otero-Rodiño, Sara Comesaña, Jesús M Míguez, and José L Soengas

-inhibited adipocyte lipolysis . Comparative Biochemistry and Physiology A 204 76 – 84 . ( doi:10.1016/j.cbpa.2016.11.011 ) 10.1016/j.cbpa.2016.11.011 Tang Z Sun C Yan A Wu S Qin C Zhang Y Li W 2013 Genes involved in fatty acid

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Keir Menzies and Johan Auwerx

reliant on substrates that drive OXPHOS activity. Lipids, which can be oxidized by mitochondria, are provided by lipolysis in adipose tissue and of intramuscular triacylglycerols. Carbohydrates, in the form of glucose, can be sequestered from the

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Shambhunath Bose, M Abul Farah, Ho-Chul Jung, Jeong-Heon Lee, and Yangsun Kim

oxidation, glycogen synthesis, and lipogenesis in addition to the inhibition of lipolysis and gluconeogenesis (reviewed by Srivastava & Mehdi 2005 ). Cumulative reports suggest that vanadium can trigger the activation of many components of insulin signaling

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Chunmei Wang and Yong Xu

Spranger J Foryst-Ludwig A Kintscher U 2012 Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis . PLoS ONE 7 e37794 . ( https://doi.org/10.1371/journal.pone.0037794 ) Berglund ED Liu C Sohn JW Liu T Kim MH Lee CE

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Raghunath Chatterjee, Paramita Bhattacharya, Oksana Gavrilova, Kimberly Glass, Jaideep Moitra, Max Myakishev, Stephanie Pack, William Jou, Lionel Feigenbaum, Michael Eckhaus, and Charles Vinson

thermogenic capacity of the aP2-A-C/EBP male mice, we stimulated them with the β3-adrenergic agonist, CL316243, which induces lipolysis in WAT and thermogenesis in BAT ( Himms-Hagen et al . 1994 ). In response to CL316243, the wild-type mice doubled their

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Junye Chen, Yi Lu, Mengyuan Tian, and Qiren Huang

Karki S Qiang L Tao R Kim J Luo Z Farmer SR Kandror KV 2011 SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL . Journal of Lipid Research 52 1693 – 1701 . ( https://doi.org/10.1194/jlr.M014647 ) 10.1194/jlr.M014647

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Dimitrios Doultsinos and Ian Mills

Teesch LM , 2017 ER stress inhibits liver fatty acid oxidation while unmitigated stress leads to anorexia-induced lipolysis and both liver and kidney steatosis . Cell Reports 19 1794 – 1806 . ( https://doi.org/10.1016/j.celrep.2017

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Anthony H Tsang, Johanna L Barclay, and Henrik Oster

gluconeogenesis in liver and lipolysis in adipose tissues ( Kwon & Hermayer 2013 ). GCs also play an important role in modulating immune ( Silverman & Sternberg 2012 ) and cognitive functions ( Sandi 2011 ). The majority of the effects of GCs are mediated by its