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D F Garcia-Diaz, J Campion, F I Milagro, N Boque, M J Moreno-Aliaga, and J A Martinez

inflammation and hyperleptinemia ( Vincent & Taylor 2006 ). Thus, induced monocyte migration to the adipose tissue and high secretion levels of some WAT-secreted adipokines are directly implicated in the obesity-associated ROS overproduction. This fact links

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Jiayu Jin, Xinhong Wang, Xiuling Zhi, and Dan Meng

, making chromatin ‘accessible’ or ‘inaccessible’ for transcription factor binding and therefore influencing gene expression (e.g. P66 , MMP-9 , IL-6 , Rac1 ). This series of events leads to ‘metabolic memory’, oxidative stress, inflammation

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Xinxin Xiang, Wenjiao An, Changtao Jiang, Jing Zhao, Xian Wang, Guang Sun, Yin Li, and Weizhen Zhang

Introduction Inflammation in adipose tissue is intimately linked with the onset and progression of insulin resistance. The link between insulin resistance and obesity is not completely understood. Recent studies suggest that insulin sensitivity is

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Nikoletta G Papadopoulou, Lauren Oleson, Duraisamy Kempuraj, Jill Donelan, Curtis L Cetrulo, and Theoharis C Theoharides

CRH ( Esposito et al. 2002 ). Such findings have implicated stress and mast cells in brain inflammation, including multiple sclerosis ( Goodin et al. 1999 , Mei-Tal et al. 1970 , Theoharides & Cochrane 2004 ), but did not prove that CRH had a

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Stacey N Walters, Jude Luzuriaga, Jeng Yie Chan, Shane T Grey, and D Ross Laybutt

antioxidant and pro-inflammatory cytokine mRNA in islet grafts Oxidative stress and inflammation have been implicated in β-cell failure in diabetes ( Laybutt et al . 2002 , Poitout & Robertson 2008 , Donath & Shoelson 2011 , Gregor & Hotamisligil 2011

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Gábor Bánhegyi, Miklós Csala, and Angelo Benedetti

the accumulation of immature proteins and triggers the unfolded protein response (UPR) that finally leads to a variety of downstream effects, such as apoptosis, inflammation, and insulin resistance ( Hotamisligil 2005 , Yoshida 2007 , Zhang & Kaufman

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Gillian A Gray, Christopher I White, Raphael F P Castellan, Sara J McSweeney, and Karen E Chapman

/macrophages and neutrophils regulates their recruitment to sites of inflammation ( Tiganescu et al. 2011 ), phagocytic potential ( Speirs et al. 2004 ) and the release of pro-inflammatory molecules ( Zhang & Daynes 2007 ). 11β-HSD1 inhibition may therefore be

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Andrew Whittle

certainly supported by functional data from humans ( McQuaid et al . 2011 ). These non-adipose tissues are poorly adapted for fat storage and as such succumb to lipotoxic effects that lead to increased insulin resistance, inflammation and apoptosis ( Virtue

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Lichun Zhou, Baohua Ma, and Xiuzhen Han

) Cardiac hypertrophy LC-3 II/I ratio and mitophagy decreased Macrophages from wild-type C57BL/6J or Atg5 +/− mice 1 μmol/L Ang II (48 h) Atg5 deficiency-mediated mitophagy aggravates cardiac inflammation and injury Zhao et al . (2014

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Ahter D Sanlioglu, Bahri Karacay, Mustafa Kemal Balci, Thomas S Griffith, and Salih Sanlioglu

Obesity and inflammation Diabetes is the third most common disease and fourth leading cause of death in the world ( Tabak et al . 2012 ). Insulin resistance, impaired glucose tolerance, and excessive glucagon secretion are the prominent features of