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Aprajita S Yadav Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA

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Nina Isoherranen Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA

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Katya B Rubinow Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, Washington, USA

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interventional strategies to mitigate body weight gain and its sequelae ( Blüher 2019 ). Vitamin A or retinol is a fat-soluble vitamin with long recognized roles in vision, growth, reproduction, and immunity. An expanding body of evidence further implicates

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-22-0078
Volume/Issue:
Volume 69: Issue 3
Free access
P Viganò Department of Obstetrics, Gynecology and Neonatology, Fondazione Policlinico-Mangiagalli-Regina Elena Hospital, University of Milano, Milano, Italy
Pathology Laboratory and Molecular Biology Laboratory, Istituto Auxologico Italiano, Via Zucchi, 18-Cusano Milanino, Milano, Italy
Dept of Obstetrics and Gynecology, Clinica Macedonio Melloni, University of Milano, Milano, Italy
BioXell S.p.A, Milano, Italy

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D Lattuada Department of Obstetrics, Gynecology and Neonatology, Fondazione Policlinico-Mangiagalli-Regina Elena Hospital, University of Milano, Milano, Italy
Pathology Laboratory and Molecular Biology Laboratory, Istituto Auxologico Italiano, Via Zucchi, 18-Cusano Milanino, Milano, Italy
Dept of Obstetrics and Gynecology, Clinica Macedonio Melloni, University of Milano, Milano, Italy
BioXell S.p.A, Milano, Italy

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S Mangioni Department of Obstetrics, Gynecology and Neonatology, Fondazione Policlinico-Mangiagalli-Regina Elena Hospital, University of Milano, Milano, Italy
Pathology Laboratory and Molecular Biology Laboratory, Istituto Auxologico Italiano, Via Zucchi, 18-Cusano Milanino, Milano, Italy
Dept of Obstetrics and Gynecology, Clinica Macedonio Melloni, University of Milano, Milano, Italy
BioXell S.p.A, Milano, Italy

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L Ermellino Department of Obstetrics, Gynecology and Neonatology, Fondazione Policlinico-Mangiagalli-Regina Elena Hospital, University of Milano, Milano, Italy
Pathology Laboratory and Molecular Biology Laboratory, Istituto Auxologico Italiano, Via Zucchi, 18-Cusano Milanino, Milano, Italy
Dept of Obstetrics and Gynecology, Clinica Macedonio Melloni, University of Milano, Milano, Italy
BioXell S.p.A, Milano, Italy

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M Vignali Department of Obstetrics, Gynecology and Neonatology, Fondazione Policlinico-Mangiagalli-Regina Elena Hospital, University of Milano, Milano, Italy
Pathology Laboratory and Molecular Biology Laboratory, Istituto Auxologico Italiano, Via Zucchi, 18-Cusano Milanino, Milano, Italy
Dept of Obstetrics and Gynecology, Clinica Macedonio Melloni, University of Milano, Milano, Italy
BioXell S.p.A, Milano, Italy

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E Caporizzo Department of Obstetrics, Gynecology and Neonatology, Fondazione Policlinico-Mangiagalli-Regina Elena Hospital, University of Milano, Milano, Italy
Pathology Laboratory and Molecular Biology Laboratory, Istituto Auxologico Italiano, Via Zucchi, 18-Cusano Milanino, Milano, Italy
Dept of Obstetrics and Gynecology, Clinica Macedonio Melloni, University of Milano, Milano, Italy
BioXell S.p.A, Milano, Italy

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P Panina-Bordignon Department of Obstetrics, Gynecology and Neonatology, Fondazione Policlinico-Mangiagalli-Regina Elena Hospital, University of Milano, Milano, Italy
Pathology Laboratory and Molecular Biology Laboratory, Istituto Auxologico Italiano, Via Zucchi, 18-Cusano Milanino, Milano, Italy
Dept of Obstetrics and Gynecology, Clinica Macedonio Melloni, University of Milano, Milano, Italy
BioXell S.p.A, Milano, Italy

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M Besozzi Department of Obstetrics, Gynecology and Neonatology, Fondazione Policlinico-Mangiagalli-Regina Elena Hospital, University of Milano, Milano, Italy
Pathology Laboratory and Molecular Biology Laboratory, Istituto Auxologico Italiano, Via Zucchi, 18-Cusano Milanino, Milano, Italy
Dept of Obstetrics and Gynecology, Clinica Macedonio Melloni, University of Milano, Milano, Italy
BioXell S.p.A, Milano, Italy

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A M Di Blasio Department of Obstetrics, Gynecology and Neonatology, Fondazione Policlinico-Mangiagalli-Regina Elena Hospital, University of Milano, Milano, Italy
Pathology Laboratory and Molecular Biology Laboratory, Istituto Auxologico Italiano, Via Zucchi, 18-Cusano Milanino, Milano, Italy
Dept of Obstetrics and Gynecology, Clinica Macedonio Melloni, University of Milano, Milano, Italy
BioXell S.p.A, Milano, Italy

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Introduction Vitamin D is a major regulator of mineral ion homeostasis by facilitating calcium and phosphate uptake in the gut and by modulating bone cell development and action ( Kumar 1980 , Jones et al. 1998 ). However, the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01946
Volume/Issue:
Volume 36: Issue 3
Free access
T Ichikawa Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka-shi, Saitama 350-1241, Japan Department of Developmental and Cell Biology, University of California, Irvine, California 92697-2300, USA Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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K Horie-Inoue Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka-shi, Saitama 350-1241, Japan Department of Developmental and Cell Biology, University of California, Irvine, California 92697-2300, USA Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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K Ikeda Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka-shi, Saitama 350-1241, Japan Department of Developmental and Cell Biology, University of California, Irvine, California 92697-2300, USA Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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B Blumberg Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka-shi, Saitama 350-1241, Japan Department of Developmental and Cell Biology, University of California, Irvine, California 92697-2300, USA Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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S Inoue Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka-shi, Saitama 350-1241, Japan Department of Developmental and Cell Biology, University of California, Irvine, California 92697-2300, USA Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka-shi, Saitama 350-1241, Japan Department of Developmental and Cell Biology, University of California, Irvine, California 92697-2300, USA Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

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Introduction Vitamin Ks are fat-soluble 2-methyl-1,4-naphthoquinone-related compounds, including natural phylloquinone (K 1 ) and menaquinones (K 2 ). Vitamins K 1 and K 2 differ only in the substituent group. Vitamin K 1 possesses a phytyl group

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-07-0048
Volume/Issue:
Volume 39: Issue 4
Free access
S M Jeyakumar Department of Biochemistry,
Department of Pathology,
National Centre for Laboratory Animal Sciences, National Institute of Nutrition, Jamai-Osmania PO, Hyderabad-500 007, Andhra Pradesh, India

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A Vajreswari Department of Biochemistry,
Department of Pathology,
National Centre for Laboratory Animal Sciences, National Institute of Nutrition, Jamai-Osmania PO, Hyderabad-500 007, Andhra Pradesh, India

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B Sesikeran Department of Biochemistry,
Department of Pathology,
National Centre for Laboratory Animal Sciences, National Institute of Nutrition, Jamai-Osmania PO, Hyderabad-500 007, Andhra Pradesh, India

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N V Giridharan Department of Biochemistry,
Department of Pathology,
National Centre for Laboratory Animal Sciences, National Institute of Nutrition, Jamai-Osmania PO, Hyderabad-500 007, Andhra Pradesh, India

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continuous recruitment of newer cells and elimination of adipocytes by apoptosis under normal physiological conditions as well as disease conditions. Vitamin A, an important micronutrient, has an unusually wide range of vital physiological actions in

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01838
Volume/Issue:
Volume 35: Issue 2
Free access
R F Chun Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Room D-3088, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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M Gacad Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Room D-3088, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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L Nguyen Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Room D-3088, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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M Hewison Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Room D-3088, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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J S Adams Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Room D-3088, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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and vitamin D receptors; VDRs), it seems unlikely that the process of binding a specific ligand will depend simply on localized concentration gradients. Whereas the mechanisms that define the intracellular localization and movement of receptor proteins

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-07-0042
Volume/Issue:
Volume 39: Issue 2
Free access
Vincent Giguère Goodman Cancer Institute and Department of Biochemistry, Faculty of Medicine, McGill University, Montréal, Québec, Canada

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from organs and biological fluids that had profound effects on reproduction, development, and general maintenance of a healthy organism. Coincidently, the chemical structure of vitamin A and the steroid hormones estradiol and progesterone were resolved

Article Type:
Editorial
DOI:
https://doi.org/10.1530/JME-22-0155
Volume/Issue:
Volume 69: Issue 4
Free access
Andrea Hanel School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

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Henna-Riikka Malmberg School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

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Carsten Carlberg School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

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Introduction The micronutrient vitamin D 3 is known best as a key regulator of calcium homeostasis, which is essential for proper bone formation ( van de Peppel & van Leeuwen 2014 , Carmeliet et al . 2015 ). Interestingly, the nuclear

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-19-0246
Volume/Issue:
Volume 64: Issue 4
Free access
Lorraine J Gudas Department of Pharmacology, and Revlon Pharmaceutical Professor of Pharmacology and Toxicology, Pharmacology Department, Weill Cornell Medicine of Cornell University, and the Meyer Cancer Center of Weill Cornell Medicine, New York, New York, USA

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Introduction and focus Vitamin A (all-trans retinol, ROL), a lipid-soluble micronutrient, is absolutely required for mammalian life. Without vitamin A, mammals develop many clinical pathologies, from xerophthalmia (dryness and inflammation of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-22-0082
Volume/Issue:
Volume 69: Issue 4
Free access
A S R Araujo
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P Schenkel
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A T Enzveiler
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T R G Fernandes
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W A Partata
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S Llesuy Departamento de Fisiologia, Cátedra de Química General y Inorgánica, Medical Sciences Division, Faculty of Medicine, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, CEP 90050-170 Porto Alegre, RS, Brazil

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M F M Ribeiro
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N Khaper Departamento de Fisiologia, Cátedra de Química General y Inorgánica, Medical Sciences Division, Faculty of Medicine, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, CEP 90050-170 Porto Alegre, RS, Brazil

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P K Singal Departamento de Fisiologia, Cátedra de Química General y Inorgánica, Medical Sciences Division, Faculty of Medicine, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, CEP 90050-170 Porto Alegre, RS, Brazil

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A Belló-Klein
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supernatant and the vitamin C standard solution (diluted in 50 mmol/l oxalic acid solution) were measured at 700 nm ( Kyaw 1978 ). TRAP TRAP, which indicates the total antioxidant capacity present in a homogenate, was measured by chemiluminescence using 2

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-08-0024
Volume/Issue:
Volume 41: Issue 6
Free access
Sang R Lee College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea

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Mi-Young Park College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea

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Hyun Yang Korean Institute of Oriental Medicine, Daejeon, Republic of Korea

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Geun-Shik Lee College of Veterinary Medicine, Kangwon National University, Chuncheon, Gangwon, Republic of Korea

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Beum-Soo An Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University, Miryang, Republic of Korea

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Bae-kuen Park College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea

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Eui-Bae Jeung College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea

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Eui-Ju Hong College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea

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have a significant role in the homeostasis of the body. While estrogen deficiency has been shown to be involved in the osteoporosis related to calcium and vitamin D ( Morris et al . 2010 ), studies have also indicated that androgens can act in concert

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0187
Volume/Issue:
Volume 60: Issue 2
Free access