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Subhamoy Dasgupta Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA

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Bert W O'Malley Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA

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Historical perspective Transcriptional coactivators are defined, broadly, as the family of coregulator molecules that interact with nuclear receptors and other transcription factors to enhance the rate of gene transcription. The existence of

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Kimberly H Cox Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

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Joseph S Takahashi Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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), with the SCN serving to synchronize ‘peripheral’ clocks ( Albrecht 2012 , Mohawk et al. 2012 ). The specific machinery underlying circadian clocks differ from organism to organism, but at the cellular level they depend on the transcription of sets of

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Inna Astapova Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA

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, Schweizer & Kohrle 2013 ). Physiological effects of TH are largely mediated by regulation of gene transcription by TH receptors (TRs): ligand-dependent transcription factors that belong to the nuclear receptor (NR) superfamily. Two different genes ( Thra

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Kumi Futawaka Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Hyogo, Japan

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Tetsuya Tagami Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan

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Yuki Fukuda Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Hyogo, Japan

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Rie Koyama Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Hyogo, Japan

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Ayaka Nushida Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Hyogo, Japan

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Shoko Nezu Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Hyogo, Japan

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Hironori Yamamoto Department of Health and Nutrition, Faculty of Human Life, Jin-ai University, Fukui, Japan

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Miyuki Imamoto Department of Nephrology and Blood Purification, Institute of Biomedical Research and Innovation, Kobe Medical Frontier Center, Kobe, Japan

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Masato Kasahara Department of Nephrology and Blood Purification, Institute of Biomedical Research and Innovation, Kobe Medical Frontier Center, Kobe, Japan

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Kenji Moriyama Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Hyogo, Japan
Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
Department of Nephrology and Blood Purification, Institute of Biomedical Research and Innovation, Kobe Medical Frontier Center, Kobe, Japan

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Introduction The active form of Vitamin D 3 (VD 3 ) is a fat-soluble vitamin that performs transcriptional control of target genes by binding to and activating the VD receptor (VDR). In the liver, the proactive form of VD 3 is hydroxylated

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Claire V Harper Department of Biology, Edge Hill University, Ormskirk, Lancashire, UK

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Anne V McNamara Systems Microscopy Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

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David G Spiller Systems Microscopy Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

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Jayne C Charnock Department of Biology, Edge Hill University, Ormskirk, Lancashire, UK

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Michael R H White Systems Microscopy Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

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Julian R E Davis Endocrine Sciences Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

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Introduction It is widely reported the that transcription of genes is not a static process and can occur in rapid bursts (with second-minute timescales ( Ozbudak et al . 2002 , Blake et al . 2003 , Raser & O’Shea 2004 , Golding et al

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Jacques Drouin Laboratoire de génétique moléculaire, Institut de recherches cliniques de Montréal (IRCM), Montréal, Québec, Canada

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Introduction The POMC gene has proven to be incredibly informative to study various aspects of gene regulation. Indeed, its restricted expression in two pituitary cell lineages provided the system to identify cell-restricted transcription

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Maxime A Tremblay Reproduction, Mother and Child Health, Centre de recherche du centre hospitalier universitaire de Québec, Québec City, Québec, Canada

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Raifish E Mendoza-Villarroel Reproduction, Mother and Child Health, Centre de recherche du centre hospitalier universitaire de Québec, Québec City, Québec, Canada

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Nicholas M Robert Reproduction, Mother and Child Health, Centre de recherche du centre hospitalier universitaire de Québec, Québec City, Québec, Canada

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Francis Bergeron Reproduction, Mother and Child Health, Centre de recherche du centre hospitalier universitaire de Québec, Québec City, Québec, Canada

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Jacques J Tremblay Reproduction, Mother and Child Health, Centre de recherche du centre hospitalier universitaire de Québec, Québec City, Québec, Canada
Centre for Research in Reproduction, Development and Intergenerational Health, Department of Obstetrics, Gynecology, and Reproduction, Faculty of Medicine, Université Laval, Québec City, Québec, Canada

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functional status ( Foresta et al. 2004 , Ivell et al. 2013 ). Despite the fact that the INSL3 promoter has been isolated from various species, very little is known regarding its transcriptional regulation. We and others have shown that transcription

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Lin Xiao Department of Surgery, Austin Health, The University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia

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Suzana Kovac Department of Surgery, Austin Health, The University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia

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Mike Chang Department of Surgery, Austin Health, The University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia

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Arthur Shulkes Department of Surgery, Austin Health, The University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia

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Graham S Baldwin Department of Surgery, Austin Health, The University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia

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Oneel Patel Department of Surgery, Austin Health, The University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia

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how the growth factors are upregulated in tumors. In the case of the gastrin promoter, various transcription factors including Sp1 ( Chupreta et al . 2000 ), p73 ( Tomkova et al . 2006 ), β-catenin/TCF4 ( Chakladar et al . 2005 ), and AP1 are

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Victoria Korsos Division of Hematology, Jewish General Hospital, Montreal, Canada
Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada

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Wilson H Miller Jr Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada
Gerald Bronfman Department of Oncology, Jewish General Hospital, Montreal, Canada
Lady Davis Institute for Medical Research, Montreal, Canada

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leukemia (APL). RARA, retinoic acid receptor alpha; mRNA, messenger ribonucleic acid; PML, promyelocytic leukemia; ATRA, all-trans retinoic acid; RT-PCR, reverse-transcription polymerase chain reaction; ATO, arsenic trioxide. Created with BioRender

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Custodia García-Jiménez
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Jose Manuel García-Martínez
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Ana Chocarro-Calvo
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Antonio De la Vieja Departamento de Fisiología y Bioquímica, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcon, Madrid, Spain

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is insulin-independent, are upregulated in many cancer cells ( Tennant et al . 2009 ). GLUTs expression is upregulated by oncogenes such as RAS , hypoxia (via increased activity of the hypoxia inducible factor transcription regulator, HIF1α

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