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members of the steroid/thyroid receptor superfamily, marking the beginning of an important 35-year (and counting) campaign to understand how this key vitamin derived from plants would play such an important role in so many aspects of our molecular
Department of Physiology, MTA-SE Laboratory of Molecular Physiology, Faculty of Medicine, Semmelweis University, PO Box 259, H-1444 Budapest, Hungary
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Department of Physiology, MTA-SE Laboratory of Molecular Physiology, Faculty of Medicine, Semmelweis University, PO Box 259, H-1444 Budapest, Hungary
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Introduction Seven transmembrane receptors (7TMRs) constitute the largest family of plasma membrane receptors. Most of their intracellular effects are mediated via direct coupling to heterotrimeric G-proteins. To understand the molecular details of
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Introduction The retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are the earliest and most intensely studied nuclear receptors (NRs) for their three-dimensional (3D) structures. Both receptor groups bind to retinoic acids (RAs
Department of Biochemistry, McGill University, Montréal, Quebec, Canada
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of genes is dependent on the action of transcription factors that transduce extra and intracellular signals into specific biological programs. Indeed, a purified fraction containing a receptor for the hormone cortisol (glucocorticoid receptor, GR) was
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Introduction The anterior pituitary gland is subjected to the stimulatory and inhibitory effects of multiple regulators. Somatostatin (SRIF) and its cognate receptors (sst1–sst5) exhibit a dominant inhibitory role in pituitary gland regulation
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Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
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progesterone can bind to their nuclear receptors namely androgen receptors (ARs), estrogen receptors (ERs) and progesterone receptors, respectively, and these receptors function as transcription factors to regulate gene expression ( Yang & Shah 2014
Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada
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Gerald Bronfman Department of Oncology, Jewish General Hospital, Montreal, Canada
Lady Davis Institute for Medical Research, Montreal, Canada
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promyelocytic leukemia ( PML ) and retinoic acid receptor alpha ( RARA ) genes and the expression of a functional PML/RARA protein. The presence of t(15;17) can be confirmed in two ways: by detection of a fused PML/RARA genomic DNA sequence using fluorescence
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responsiveness to leptin may vary according to the metabolic conditions ( Widdowson et al . 1997 ) and leptin resistance is relevant to leptin receptors ( Lrb ) or their downstream signaling pathway ( Martin et al . 2000 ). Our previous studies showed that the
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receptor (MR or NR3C2; Arriza et al . 1987 ). The MR is a member of the steroid/thyroid hormone receptor superfamily of ligand-inducible transcription factors. Other NR in this family include the glucocorticoid (GR or NR3C1; Weinberger et al . 1985
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Estrogen receptor The vast majority of estrogen's activities are mediated by the estrogen receptor (ER), a member of the nuclear receptor family of hormone activated transcription factors. Our understanding of the physiological role of estrogen
