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Matei Bolborea, Gisela Helfer, Francis J P Ebling and Perry Barrett

cyclase is a signal transduction pathway commonly associated with TSH receptor activation, but TSH receptors are known to couple with a diverse range of G proteins to activate several different pathways that potentially have multiple downstream

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M Hołysz, N Derebecka-Hołysz and W H Trzeciak

( Trzeciak & Boyd 1974 , Boyd et al . 1975 ). ACTH binds to a specific receptor coupled with membrane-bound adenylyl cyclase; thus, cAMP is generated and activates the protein kinase A (PKA) signal transduction pathway, which leads to phosphorylation and

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Baowei Jiao, Xigui Huang, Chi Bun Chan, Li Zhang, Deshou Wang and Christopher H K Cheng

substituted by an YXXFS motif. In addition, there are two conserved regions within the intracellular domain termed Box 1 and Box 2 that are important for signal transduction of the receptor. The proline-rich Box 1 region is the site of Janus kinase 2 (JAK2

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Gábor Turu and László Hunyady

this review is to discuss the intracellular mechanisms of the action of CB 1 R. After summarizing the available data about the G-protein activation and signal transduction of CB 1 R, this review also analyses recent data about dimerization or

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Gerald Thiel, Isabelle Müller and Oliver G Rössler

Islam MS 2011 TRP channels of islets. In: Transient receptor potential channels. Advances in Experimental Medicine and Biology 704 811–830 (Fig. 42.1) with kind permission from Springer Science+Business Media B.V.). Figure 3 Signal transduction of

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N Martínez-Micaelo, N González-Abuín, A Ardévol, M Pinent, E Petretto, J Behmoaras and M Blay

consequence of a differential regulation of the leptin signalling pathway genes, the expression of key genes involved in the regulation of leptin signal transduction in relevant organs, including the mesenteric fat pad, the hypothalamus and the liver was

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Marta Labeur, Barbara Wölfel, Johanna Stalla and Günter K Stalla

and as RA, a CRH signaling pathway inhibitor, may modulate TMEFF2, we decided to investigate in detail the effects of TMEFF2 on the signal transduction pathway of CRH. Materials and methods Cell culture and chemicals AtT20 pituitary corticotrope tumor

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Fadil M Hannan, Valerie N Babinsky and Rajesh V Thakker

G proteins and other components of the CaSR signal transduction pathway ( Leach et al . 2012 ). Some loss-of-function CaSR mutations have been shown to cause signalling bias by switching the wild-type CaSR from preferentially coupling with

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Hong Zhou, Yonghua Jiang, Wendy K W Ko, Wensheng Li and Anderson O L Wong

. Furthermore, we also speculate that (i) the JAK2/MAPK cascades secondary coupled to the cAMP-dependent pathway and (ii) the PI3K cascade independent of cAMP-mediated mechanisms may be the key elements in the signal transduction for LH-induced GH gene

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Michelle Mohyi and Terry J Smith

uncharacterized; however, key insights have begun to emerge. Signal transduction pathways used by the two receptors overlap ( Dupont & LeRoith 2001 , Latif et al . 2009 , Morshed et al . 2009 , 2010 ), suggesting the potential for functional interplay between