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Custodia García-Jiménez
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Jose Manuel García-Martínez
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Ana Chocarro-Calvo
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Antonio De la Vieja Departamento de Fisiología y Bioquímica, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcon, Madrid, Spain

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unexplored aspect is the influence of high glucose levels on cancer signaling. In this context, high glucose has been shown to be essential for WNT/β-catenin signaling, a key cancer-associated pathway ( Anagnostou & Shepherd 2008 , Chocarro-Calvo et al

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-13-0152
Volume/Issue:
Volume 52: Issue 1
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Kathryn L Auld
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Stephen P Berasi Pfizer Global Biotherapeutics Technologies, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer Oncology Research and Development, Former Wyeth Colleagues, Cambridge, Massachusetts, USA

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Yan Liu Pfizer Global Biotherapeutics Technologies, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer Oncology Research and Development, Former Wyeth Colleagues, Cambridge, Massachusetts, USA

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Michael Cain Pfizer Global Biotherapeutics Technologies, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer Oncology Research and Development, Former Wyeth Colleagues, Cambridge, Massachusetts, USA

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Ying Zhang Pfizer Global Biotherapeutics Technologies, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer Oncology Research and Development, Former Wyeth Colleagues, Cambridge, Massachusetts, USA

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Christine Huard Pfizer Global Biotherapeutics Technologies, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer Oncology Research and Development, Former Wyeth Colleagues, Cambridge, Massachusetts, USA

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Shoichi Fukayama Pfizer Global Biotherapeutics Technologies, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer Oncology Research and Development, Former Wyeth Colleagues, Cambridge, Massachusetts, USA

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Jing Zhang
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Sung Choe
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Wenyan Zhong Pfizer Global Biotherapeutics Technologies, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer Oncology Research and Development, Former Wyeth Colleagues, Cambridge, Massachusetts, USA

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Bheem M Bhat Pfizer Global Biotherapeutics Technologies, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer Oncology Research and Development, Former Wyeth Colleagues, Cambridge, Massachusetts, USA

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Ramesh A Bhat Pfizer Global Biotherapeutics Technologies, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer Oncology Research and Development, Former Wyeth Colleagues, Cambridge, Massachusetts, USA

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Eugene L Brown Pfizer Global Biotherapeutics Technologies, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer Oncology Research and Development, Former Wyeth Colleagues, Cambridge, Massachusetts, USA

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Robert V Martinez Pfizer Global Biotherapeutics Technologies, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer BioTherapeutics Research and Development, Pfizer Oncology Research and Development, Former Wyeth Colleagues, Cambridge, Massachusetts, USA

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ERRα acts as an inhibitor of osteoblast differentiation in vitro ( Teyssier et al . 2009 ). The Wnt pathway is another important player in bone development (reviewed in Bodine & Komm (2006) ). During canonical Wnt/β-catenin signaling, Wnt ligands

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-11-0140
Volume/Issue:
Volume 48: Issue 2
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Samantha Gardner Medical Research Council Human Reproductive Sciences Unit, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK

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Emmanouil Stavrou Medical Research Council Human Reproductive Sciences Unit, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK

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Patricia E Rischitor Medical Research Council Human Reproductive Sciences Unit, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK

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Elena Faccenda Medical Research Council Human Reproductive Sciences Unit, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK

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Adam J Pawson Medical Research Council Human Reproductive Sciences Unit, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK

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. 2004 , 2008 , Pawson & McNeilly 2005 , Naor 2009 ), and will not be discussed further here. Instead, this review will focus on the proposed roles of Wnt signalling mediators in regulating gonadotrope function in response to GnRH. A ‘rough guide’ to

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-09-0168
Volume/Issue:
Volume 44: Issue 4
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Matthias Laudes Department of Internal Medicine II, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany

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during the last decade revealed that many wingless-type MMTV integration site family members (WNT) signalling molecules act as negative regulators of adipogenesis in cell lines, rodents and humans. In general, it has been suggested that inhibition of WNT

Article Type:
Research Article
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https://doi.org/10.1530/JME-10-0169
Volume/Issue:
Volume 46: Issue 2
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Ke-feng Yang Clinical Nutrition Center, Department of Nutrition, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, People's Republic of China
Clinical Nutrition Center, Department of Nutrition, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, People's Republic of China
Clinical Nutrition Center, Department of Nutrition, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, People's Republic of China
Clinical Nutrition Center, Department of Nutrition, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, People's Republic of China

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Wei Cai Clinical Nutrition Center, Department of Nutrition, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, People's Republic of China
Clinical Nutrition Center, Department of Nutrition, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, People's Republic of China
Clinical Nutrition Center, Department of Nutrition, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, People's Republic of China
Clinical Nutrition Center, Department of Nutrition, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, People's Republic of China

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Jia-li Xu Clinical Nutrition Center, Department of Nutrition, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, People's Republic of China

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Wen Shi Clinical Nutrition Center, Department of Nutrition, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, People's Republic of China

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nutritional programming on liver metabolism and gene expression ( Brameld et al . 2000 , Buckley et al . 2005 ). As a critical regulator of liver development, the Wnt signaling pathway is essential for embryonic liver development, postnatal liver growth

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0046
Volume/Issue:
Volume 49: Issue 2
Free access
Su M Hlaing Departments of Internal Medicine, Health and Life Sciences, Division of Endocrinology, Department of Medicine, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA

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Leah A Garcia Departments of Internal Medicine, Health and Life Sciences, Division of Endocrinology, Department of Medicine, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA

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Jaime R Contreras Departments of Internal Medicine, Health and Life Sciences, Division of Endocrinology, Department of Medicine, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA

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Keith C Norris Departments of Internal Medicine, Health and Life Sciences, Division of Endocrinology, Department of Medicine, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA

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Monica G Ferrini Departments of Internal Medicine, Health and Life Sciences, Division of Endocrinology, Department of Medicine, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
Departments of Internal Medicine, Health and Life Sciences, Division of Endocrinology, Department of Medicine, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
Departments of Internal Medicine, Health and Life Sciences, Division of Endocrinology, Department of Medicine, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA

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Jorge N Artaza Departments of Internal Medicine, Health and Life Sciences, Division of Endocrinology, Department of Medicine, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
Departments of Internal Medicine, Health and Life Sciences, Division of Endocrinology, Department of Medicine, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
Departments of Internal Medicine, Health and Life Sciences, Division of Endocrinology, Department of Medicine, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
Departments of Internal Medicine, Health and Life Sciences, Division of Endocrinology, Department of Medicine, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA

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. 2007 ). The aim of this study was to test the hypothesis that 1,25-D 3 promotes myocardiac cell differentiation through inhibition of the WNT signaling pathway and to determine the associated molecular mechanism(s) in a well-known and widely used heart

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-14-0168
Volume/Issue:
Volume 53: Issue 3
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Changgui Shi Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China
Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Ping Huang Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Hui Kang Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Bo Hu Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China
Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Jin Qi Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Min Jiang Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Hanbing Zhou Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Lei Guo Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Lianfu Deng Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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. 2012 , Ma et al . 2012 , Wei et al . 2012 , Xu et al . 2012 a , b , Chiyomaru et al . 2013 , Wu et al . 2013 ). Moreover, these six miRNAs have been reported to regulate the WNT signaling pathway ( Chiyomaru et al . 2013 , Liu et al . 2013

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-14-0314
Volume/Issue:
Volume 54: Issue 3
Free access
Chen Chen Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry and Key Laboratory of Agricultural Animal Genetics, Hunan Institute of Animal and Veterinary Science, Department of Animal Nutrition and Feed Science, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China
Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry and Key Laboratory of Agricultural Animal Genetics, Hunan Institute of Animal and Veterinary Science, Department of Animal Nutrition and Feed Science, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China

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Yongdong Peng Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry and Key Laboratory of Agricultural Animal Genetics, Hunan Institute of Animal and Veterinary Science, Department of Animal Nutrition and Feed Science, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China

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Yinglin Peng Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry and Key Laboratory of Agricultural Animal Genetics, Hunan Institute of Animal and Veterinary Science, Department of Animal Nutrition and Feed Science, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China

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Jian Peng Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry and Key Laboratory of Agricultural Animal Genetics, Hunan Institute of Animal and Veterinary Science, Department of Animal Nutrition and Feed Science, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China

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Siwen Jiang Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry and Key Laboratory of Agricultural Animal Genetics, Hunan Institute of Animal and Veterinary Science, Department of Animal Nutrition and Feed Science, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China

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family impair preadipocyte differentiation ( Karbiener et al . 2009 , Sun et al . 2009 , Kim et al . 2010 ). In addition, miR-210 has been reported to promote adipogenesis by inhibiting the canonical Wnt/β-catenin signaling pathway ( Qin et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-14-0013
Volume/Issue:
Volume 52: Issue 3
Free access
Rui Wang Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Jie Hong Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Ruixin Liu Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Maopei Chen Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Min Xu Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Wiqiong Gu Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Yifei Zhang Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Qinyun Ma Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Feng Wang Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Juan Shi Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Jiqiu Wang Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Weiqing Wang Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Guang Ning Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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that evoked WNT/β-catenin signalling in white and brown preadipocytes leads to the maintenance of the undifferentiated state and prevents the induction of CCAAT/enhancer-binding protein α (Cebpa) and peroxisome proliferator-activated receptor γ (Pparg

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-14-0037
Volume/Issue:
Volume 53: Issue 3
Free access
Weijuan Shao Division of Advanced Diagnostics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada

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Vivian Szeto Department of Physiology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada

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Zhuolun Song Department of Physiology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada

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Lili Tian Division of Advanced Diagnostics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada

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Zhong-Ping Feng Department of Physiology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada

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M Cristina Nostro Department of Physiology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada

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Tianru Jin Division of Advanced Diagnostics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada
Banting and Best Diabetes Center, University of Toronto, Toronto, Ontario, Canada

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explore functions of this Wnt signaling pathway effector in pancreatic β-cells and elsewhere ( Schafer et al . 2007 , Norton et al . 2011 , 2014 , Ip et al . 2012 , 2015 , Kaminska et al . 2012 , Jin 2016 ). Previous in vitro and ex vivo

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0181
Volume/Issue:
Volume 61: Issue 1
Free access