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Farhana Naznin, Koji Toshinai, T M Zaved Waise, Tadashi Okada, Hideyuki Sakoda, and Masamitsu Nakazato

these DIO experiments used C57BL/6J mice, which develop severe obesity, hyperglycemia and insulin resistance ( Reed et al . 2007 ). Consumption of HFD induces immune cell-mediated tissue inflammation in the gut, adipose tissue, liver, skeletal muscle

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J Jason Collier, Tim E Sparer, Michael D Karlstad, and Susan J Burke

& Stewart 1984 , Foulis et al . 1991 , Boni-Schnetzler et al . 2008 , Donath et al . 2008 , Hanafusa & Imagawa 2008 ), we and others have focused a significant portion of our research efforts into understanding the inflammation-associated processes

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Kira Meyerovich, Fernanda Ortis, Florent Allagnat, and Alessandra K Cardozo

role of the UPR in the context of β-cell demise leading to diabetes ( Brozzi & Eizirik 2016 , Hasnain et al. 2016 ). This article focuses on (1) the signal transduction pathways involved in the UPR and their connections to inflammation, (2) the

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Shaoqian Zhao, Wen Liu, Jiqiu Wang, Juan Shi, Yingkai Sun, Weiqing Wang, Guang Ning, Ruixin Liu, and Jie Hong

-fed mice with A. muciniphila at 2 × 10 8 colony-forming units (CFUs)/200 μL by daily gavage for five weeks to reveal the effects of A. muciniphila supplementation in normal mice regarding glucose metabolism and inflammation. Our results demonstrated

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Tae Woo Jung, Yoon Hee Chung, Hyoung-Chun Kim, A M Abd El-Aty, and Ji Hoon Jeong

Introduction The main features of adipose tissue dysfunction in obesity and metabolic syndrome are chronic low-grade inflammation in adipose tissue and macrophage infiltration ( Hajer et al . 2008 , Bluher 2009 ). The large numbers of

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Evan R Simpson and Kristy A Brown

metastasis-free survival in women with ER-positive tumours. Breast inflammation and aromatase expression Powerful evidence in support of the relationship of breast inflammation and aromatase expression has come from a series of studies by the group of

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Huixia Li, Zhuanmin Zhang, Dongxu Feng, Lin Xu, Fang Li, Jiali Liu, Xinxin Jin, Zhuang Qian, Xiaomin Kang, and Hongzhi Sun

the pathogenesis of type 2 diabetes mellitus (T2DM). In particular, circulating PGRN is positively correlated with macrophage infiltration in omental AT of T2DM subjects and implicated in inflammation and atherosclerosis in subjects with metabolic

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Hyeon Young Park, Hye Suk Kang, and Seung-Soon Im

studies have successfully shown connections among metabolism, immunity and inflammation at the intracellular level ( Ertunc & Hotamisligil 2016 , Buck et al . 2017 ). Early immunometabolism studies described the metabolic demands for the function of

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Rosalia C M Simmen and Angela S Kelley

the inflammatory regulatory hierarchy. Importantly, as inflammation is well considered as one of the major contributors to the development and progression of endometriosis, the study findings offer promise for novel therapeutic strategies that may be

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Caitlyn Nguyen-Ngo, Nanthini Jayabalan, Carlos Salomon, and Martha Lappas

effective intervention that can prevent GDM and thereby reduce its burden. Pathophysiology of GDM There are several distinct features of GDM pathophysiology including peripheral maternal insulin resistance, inflammation, and placental and endothelial