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Irit Hochberg, Innocence Harvey, Quynh T Tran, Erin J Stephenson, Ariel L Barkan, Alan R Saltiel, William F Chandler, and Dave Bridges

leads to similar clinical manifestations. Numerous studies have shown that glucocorticoids have profound effects on adipose tissue metabolism, including the promotion of adipocyte differentiation ( Hauner et al . 1987 ) and induction of lipolysis and

Open access

Hyon-Seung Yi, Joon Young Chang, and Minho Shong

-sucrose diet-fed mice by sirtuin-mediated UPR mt , triggering an adaptive mitohormesis in the liver of mice ( Gariani et al . 2016 ). The UPR mt induced by skeletal muscle-specific OxPhos deficiency is also associated with enhanced lipolysis and fatty acid

Open access

Oro Uchenunu, Michael Pollak, Ivan Topisirovic, and Laura Hulea

expenditure, reduced lipolysis and greater fatty acid re-esterification in the adipose tissue ( Le Bacquer et al . 2007 ). Furthermore, resistance to insulin in EIF4EBP1 and EIF4EBP2 double knockout mice was associated with increased RPS6KB activity