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Rachel S Fletcher Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Gareth G Lavery Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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mammalian cells, a number of NAD + biosynthesis pathways have been established. These pathways can synthesise NAD + de novo from l -tryptophan or from the salvage of vitamin B3 NAD + precursors nicotinic acid (NA), nicotinamide (NAM) and nicotinamide

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-18-0085
Volume/Issue:
Volume 61: Issue 3
Open access
Jo E Lewis Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK
Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK

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John M Brameld Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK

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Phil Hill Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK

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Dana Wilson Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK

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Perry Barrett Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK

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Francis J P Ebling Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK

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Preeti H Jethwa Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK

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), supporting the view that the products of this gene might impact upon seasonal behavior and physiology. In silico analysis of the mouse VGF promoter sequence revealed a potential thyroid response element (TRE), as well as a vitamin D response element (VDRE

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-15-0224
Volume/Issue:
Volume 56: Issue 2
Open access
Yali Ling National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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Feng Xu National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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Xuedi Xia National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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Dexing Dai National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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Ruoman Sun National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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Zhongjian Xie National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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stage and to better prevent the progression of the tumor. The vitamin D receptor (VDR), a well-known member of the nuclear receptor superfamily, mediates the action of 1,25-dihydroxyvitamin D 3 (1,25(OH)₂D 3 ). VDR is widely expressed in multiple

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-21-0167
Volume/Issue:
Volume 68: Issue 3
Open access
Fraydoon Rastinejad Nuffield Department of Medicine, University of Oxford, Target Discovery Institute (NDM RB), Oxford, UK

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to RXRs and RARs follows a more general concept appreciated for the NR family by which endogenous lipophilic molecules, representing cellular signals, including RAs, vitamin D3, thyroid hormone, fatty acids and heme, are selectively bound in the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-22-0113
Volume/Issue:
Volume 69: Issue 4
Open access
Xiaojing Wei Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, China
Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi’an Jiaotong University, Xi’an, China
Institute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, China

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Yutian Tan Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, China
Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi’an Jiaotong University, Xi’an, China
Institute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, China

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Jiaqi Huang Institute of Basic Medicine, School of Medicine, Tsinghua University, Beijing, China

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Ximing Dong Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, China
Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi’an Jiaotong University, Xi’an, China
Institute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, China

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Weijie Feng Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, China
Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi’an Jiaotong University, Xi’an, China
Institute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, China

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Tanglin Liu Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, China
Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi’an Jiaotong University, Xi’an, China
Institute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, China

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Zhao Yang Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

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Guiying Yang Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

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Xiao Luo Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, China
Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi’an Jiaotong University, Xi’an, China
Institute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, China

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treatment in nonpregnant mice did not change either GTT. In summary, the placenta may be the major reason for the unexpected impaired GTT of maternal mice in the current study. Conclusion As a major metabolite of vitamin B3 produced by NNMT, MNAM has

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-23-0126
Volume/Issue:
Volume 72: Issue 2
Open access
Fadil M Hannan Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK

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Valerie N Babinsky Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, UK

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Rajesh V Thakker Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, UK

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Introduction Extracellular calcium (Ca 2+ o ) is essential for the regulation of a variety of biological processes including neuromuscular excitability, blood coagulation and mineralisation of bone matrix and for providing a steady supply of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-16-0124
Volume/Issue:
Volume 57: Issue 3
Open access
Douglas R Houston Institute of Quantitative Biology, Biochemistry, and Biotechnology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK

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Jane G Hanna Institute of Quantitative Biology, Biochemistry, and Biotechnology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK

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J Constance Lathe Program in Neuroscience, University of Glasgow, Glasgow, UK

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Stephen G Hillier Medical Research Council Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Richard Lathe Division of Infection Medicine, University of Edinburgh, Edinburgh, UK

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-Escardó et al. 2019 ), confirming that true NRs are a Metazoan innovation. Few new protein domains were acquired at the pre-Metazoa to Metazoa transition (780–540 Mya; Erwin et al. 2011 ), and the majority of innovations were instead generated through

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-21-0156
Volume/Issue:
Volume 68: Issue 3
Open access
M H Abel
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D Baban
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S Lee
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H M Charlton
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P J O'Shaughnessy Department of Physiology, Institute of Comparative Medicine, Anatomy and Genetics, University of Oxford, Le Gros Clarke Building, Oxford OX1 3QX, UK

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– 975 . O'Shaughnessy PJ Abel M Charlton HM Hu B Johnston H Baker PJ 2007 Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-08-0107
Volume/Issue:
Volume 42: Issue 4
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Yanjun Cui State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Science, Beijing 100193, People's Republic of China

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Xianhong Gu State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Science, Beijing 100193, People's Republic of China

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.0 Chemical composition b  Digestive energy (MJ/kg) 13.39  Crude protein 157.3  Calcium 6.5  Total phosphorus 4.1  Available phosphorus 1.7  Lysine 9.2  Met+Cys 5.4 a Premix provided the following per kg of complete diet for finisher pigs: vitamin A, 2512 IU

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-15-0161
Volume/Issue:
Volume 55: Issue 3
Open access
Weiye Zhao Department of Biology, University of York, York, UK

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Susanna F Rose Department of Biology, University of York, York, UK

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Ryan Blake CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Aňze Godicelj Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Smith Building, Boston, Massachusetts, USA

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Amy E Cullen CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Jack Stenning Department of Biology, University of York, York, UK

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Lucy Beevors The Institute of Metabolism and Systems Research (IMSR), University of Birmingham, College of Medical and Dental Sciences, Birmingham, UK

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Marcel Gehrung CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Sanjeev Kumar Chris O’Brien Lifehouse, Sydney, New South Wales, Australia

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Kamal Kishore CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Ashley Sawle CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Matthew Eldridge CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Federico M Giorgi Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy

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Katherine S Bridge Department of Biology, University of York, York, UK
York Biomedical Research Institute, University of York, York, UK

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Florian Markowetz CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Andrew N Holding Department of Biology, University of York, York, UK
York Biomedical Research Institute, University of York, York, UK
The Alan Turing Institute, Kings Cross, London, UK

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the tumour ( Mohammed et al. 2013 ). Only a few primary breast cancers have mutations in the ER ( Oesterreich & Davidson 2013 ), yet the transcriptional activity is frequently abnormal ( Carroll 2016 ). In many metastatic tumours, the ER is still

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-23-0133
Volume/Issue:
Volume 73: Issue 1
Open access