Filter

Refine by collections

Refine by access

Refine by date

—
  • Print
  • Save

Search Results

You are looking at 1 - 10 of 83 items for :

  • transcription x
  • Refine by access: Open Access content only x
Clear All
Claire V Harper Department of Biology, Edge Hill University, Ormskirk, Lancashire, UK

Search for other papers by Claire V Harper in
Google Scholar
PubMed Close
,
Anne V McNamara Systems Microscopy Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

Search for other papers by Anne V McNamara in
Google Scholar
PubMed Close
,
David G Spiller Systems Microscopy Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

Search for other papers by David G Spiller in
Google Scholar
PubMed Close
,
Jayne C Charnock Department of Biology, Edge Hill University, Ormskirk, Lancashire, UK

Search for other papers by Jayne C Charnock in
Google Scholar
PubMed Close
,
Michael R H White Systems Microscopy Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

Search for other papers by Michael R H White in
Google Scholar
PubMed Close
, and
Julian R E Davis Endocrine Sciences Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

Search for other papers by Julian R E Davis in
Google Scholar
PubMed Close

Introduction It is widely reported the that transcription of genes is not a static process and can occur in rapid bursts (with second-minute timescales ( Ozbudak et al . 2002 , Blake et al . 2003 , Raser & O’Shea 2004 , Golding et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-20-0223
Volume/Issue:
Volume 66: Issue 1
Open access
Dorka Nagy Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, UK
National Heart and Lung Institute, Imperial College London, London, UK

Search for other papers by Dorka Nagy in
Google Scholar
PubMed Close
,
Hannah Maude Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, UK

Search for other papers by Hannah Maude in
Google Scholar
PubMed Close
,
Graeme M Birdsey National Heart and Lung Institute, Imperial College London, London, UK

Search for other papers by Graeme M Birdsey in
Google Scholar
PubMed Close
,
Anna M Randi National Heart and Lung Institute, Imperial College London, London, UK

Search for other papers by Anna M Randi in
Google Scholar
PubMed Close
, and
Inês Cebola Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, UK

Search for other papers by Inês Cebola in
Google Scholar
PubMed Close

tissue (~80% of its mass) has made it difficult to assess and analyse LSEC-specific aspects of gene expression, chromatin accessibility, and transcription factor (TF) occupancy using bulk liver tissue. With advances in cell isolation techniques and single

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JME-23-0026
Volume/Issue:
Volume 71: Issue 2
Open access
Feng Zhang Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

Search for other papers by Feng Zhang in
Google Scholar
PubMed Close
,
Qi Xiong Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

Search for other papers by Qi Xiong in
Google Scholar
PubMed Close
,
Hu Tao Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

Search for other papers by Hu Tao in
Google Scholar
PubMed Close
,
Yang Liu Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

Search for other papers by Yang Liu in
Google Scholar
PubMed Close
,
Nian Zhang Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

Search for other papers by Nian Zhang in
Google Scholar
PubMed Close
,
Xiao-Feng Li Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

Search for other papers by Xiao-Feng Li in
Google Scholar
PubMed Close
,
Xiao-Jun Suo Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

Search for other papers by Xiao-Jun Suo in
Google Scholar
PubMed Close
,
Qian-Ping Yang Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

Search for other papers by Qian-Ping Yang in
Google Scholar
PubMed Close
, and
Ming-Xin Chen Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

Search for other papers by Ming-Xin Chen in
Google Scholar
PubMed Close

backfat thickness tended to be greater in Korean cattle ( Lee et al. 2010 ). However, to our knowledge, the role of ACOX1 in intramuscular adipogenesis of beef cattle has not been reported, and its transcriptional and post-transcriptional regulatory

Article Type:
Research Article
Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/JME-20-0250
Volume/Issue:
Volume 66: Issue 3
Open access
Rikus Botha Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand

Search for other papers by Rikus Botha in
Google Scholar
PubMed Close
,
Shree S Kumar Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand

Search for other papers by Shree S Kumar in
Google Scholar
PubMed Close
,
Natasha L Grimsey Department of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand
Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand
Maurice Wilkins Centre for Biodiscovery, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand

Search for other papers by Natasha L Grimsey in
Google Scholar
PubMed Close
, and
Kathleen G Mountjoy Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand
Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand
Maurice Wilkins Centre for Biodiscovery, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand
Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand

Search for other papers by Kathleen G Mountjoy in
Google Scholar
PubMed Close

enhanced hMC4R signaling was predicted to associate with a lean phenotype. Two of these variants, H76R ( Gillyard et al. 2019 ) and L250Q ( Xiang et al. 2006 ), were shown to have reduced agonist-activated CRE-driven transcription activity in vitro

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-23-0008
Volume/Issue:
Volume 71: Issue 1
Open access
Richard Barbuto Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Room 4342, Toronto, Ontario, Canada M5S 1A8

Search for other papers by Richard Barbuto in
Google Scholar
PubMed Close
and
Jane Mitchell Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Room 4342, Toronto, Ontario, Canada M5S 1A8

Search for other papers by Jane Mitchell in
Google Scholar
PubMed Close

Introduction Osterix ( Osx , Sp7 ) is a zinc-finger containing transcription factor of the specificity protein (Sp) family that is essential for osteoblast differentiation and embryonic skeletal development. Osx -deficient mice accumulate

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0251
Volume/Issue:
Volume 51: Issue 1
Open access
View license
Hong Chen Department of Endocrinology, Genetics and Metabolism, Fuzhou Children’s Hospital of Fujian Medical University, Fuzhou, China

Search for other papers by Hong Chen in
Google Scholar
PubMed Close
,
Weiyu Li Department of Endocrinology, Genetics and Metabolism, Fuzhou Children’s Hospital of Fujian Medical University, Fuzhou, China

Search for other papers by Weiyu Li in
Google Scholar
PubMed Close
,
Suping Zhang Department of Endocrinology, Genetics and Metabolism, Fuzhou Children’s Hospital of Fujian Medical University, Fuzhou, China

Search for other papers by Suping Zhang in
Google Scholar
PubMed Close
,
Yunteng Sun Department of Endocrinology, Genetics and Metabolism, Fuzhou Children’s Hospital of Fujian Medical University, Fuzhou, China

Search for other papers by Yunteng Sun in
Google Scholar
PubMed Close
,
Yiping Shen Department of Genetic and Metabolic Central Laboratory, the Maternal and Child Health Care Hospital of Guangxi Zhuang Autonomous Region, Guangxi Birth Defects Prevention and Control Institute, Nanning, China
Division of Genetics and Genomics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA

Search for other papers by Yiping Shen in
Google Scholar
PubMed Close
, and
Ruimin Chen Department of Endocrinology, Genetics and Metabolism, Fuzhou Children’s Hospital of Fujian Medical University, Fuzhou, China

Search for other papers by Ruimin Chen in
Google Scholar
PubMed Close

Introduction CCCTC-binding factor (coded by CTCF gene, OMIM *604167), as a transcription insulation protein, plays a key role in regulating the temporal and spatial transcription of genes related to growth in mammals and topologically

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-22-0193
Volume/Issue:
Volume 70: Issue 4
Open access
Shalinee Dhayal Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

Search for other papers by Shalinee Dhayal in
Google Scholar
PubMed Close
,
Kaiyven Afi Leslie Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

Search for other papers by Kaiyven Afi Leslie in
Google Scholar
PubMed Close
,
Mohammad Baity Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

Search for other papers by Mohammad Baity in
Google Scholar
PubMed Close
,
Pouria Akhbari Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

Search for other papers by Pouria Akhbari in
Google Scholar
PubMed Close
,
Sarah J Richardson Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

Search for other papers by Sarah J Richardson in
Google Scholar
PubMed Close
,
Mark A Russell Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

Search for other papers by Mark A Russell in
Google Scholar
PubMed Close
, and
Noel G Morgan Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

Search for other papers by Noel G Morgan in
Google Scholar
PubMed Close

receptors on specific tyrosine residues leading to the recruitment and subsequent phosphorylation of defined subsets of transcription factor belonging to the signal transducer and activator of transcription (STAT) family. In the case of type I and type III

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-21-0224
Volume/Issue:
Volume 69: Issue 2
Open access
Yihong Wan Department of Pharmacology, Gene Expression Laboratory, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Room ND8.502B, Dallas, Texas 75390-9041, USA
Department of Pharmacology, Gene Expression Laboratory, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Room ND8.502B, Dallas, Texas 75390-9041, USA

Search for other papers by Yihong Wan in
Google Scholar
PubMed Close
and
Ronald M Evans Department of Pharmacology, Gene Expression Laboratory, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Room ND8.502B, Dallas, Texas 75390-9041, USA

Search for other papers by Ronald M Evans in
Google Scholar
PubMed Close

receptor superfamily of ligand-responsive transcription factors ( Evans et al . 2004 ). It forms a functional heterodimer with the retinoid receptor (RXR)α. Certain lipophilic compounds have been identified as PPARγ ligands that can bind to the receptor

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-09-0090
Volume/Issue:
Volume 44: Issue 2
Open access
View license
James G Yarger
Search for other papers by James G Yarger in
Google Scholar
PubMed Close
,
Robert E Babine ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

Search for other papers by Robert E Babine in
Google Scholar
PubMed Close
,
Michael Bittner ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

Search for other papers by Michael Bittner in
Google Scholar
PubMed Close
,
Erin Shanle ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

Search for other papers by Erin Shanle in
Google Scholar
PubMed Close
,
Wei Xu ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

Search for other papers by Wei Xu in
Google Scholar
PubMed Close
,
Pamela Hershberger ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

Search for other papers by Pamela Hershberger in
Google Scholar
PubMed Close
, and
Steven H Nye
Search for other papers by Steven H Nye in
Google Scholar
PubMed Close

Introduction Nuclear receptors are transcription factors that play a key role in both embryonic development ( Chung & Cooney 2003 ) and adult homeostasis ( Strauss et al . 2009 , Colasanti et al . 2011 , Ribas et al . 2011 ), and are a common

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0083
Volume/Issue:
Volume 50: Issue 1
Open access
View license
Weiye Zhao Department of Biology, University of York, York, UK

Search for other papers by Weiye Zhao in
Google Scholar
PubMed Close
,
Susanna F Rose Department of Biology, University of York, York, UK

Search for other papers by Susanna F Rose in
Google Scholar
PubMed Close
,
Ryan Blake CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

Search for other papers by Ryan Blake in
Google Scholar
PubMed Close
,
Aňze Godicelj Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Smith Building, Boston, Massachusetts, USA

Search for other papers by Aňze Godicelj in
Google Scholar
PubMed Close
,
Amy E Cullen CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

Search for other papers by Amy E Cullen in
Google Scholar
PubMed Close
,
Jack Stenning Department of Biology, University of York, York, UK

Search for other papers by Jack Stenning in
Google Scholar
PubMed Close
,
Lucy Beevors The Institute of Metabolism and Systems Research (IMSR), University of Birmingham, College of Medical and Dental Sciences, Birmingham, UK

Search for other papers by Lucy Beevors in
Google Scholar
PubMed Close
,
Marcel Gehrung CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

Search for other papers by Marcel Gehrung in
Google Scholar
PubMed Close
,
Sanjeev Kumar Chris O’Brien Lifehouse, Sydney, New South Wales, Australia

Search for other papers by Sanjeev Kumar in
Google Scholar
PubMed Close
,
Kamal Kishore CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

Search for other papers by Kamal Kishore in
Google Scholar
PubMed Close
,
Ashley Sawle CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

Search for other papers by Ashley Sawle in
Google Scholar
PubMed Close
,
Matthew Eldridge CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

Search for other papers by Matthew Eldridge in
Google Scholar
PubMed Close
,
Federico M Giorgi Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy

Search for other papers by Federico M Giorgi in
Google Scholar
PubMed Close
,
Katherine S Bridge Department of Biology, University of York, York, UK
York Biomedical Research Institute, University of York, York, UK

Search for other papers by Katherine S Bridge in
Google Scholar
PubMed Close
,
Florian Markowetz CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

Search for other papers by Florian Markowetz in
Google Scholar
PubMed Close
, and
Andrew N Holding Department of Biology, University of York, York, UK
York Biomedical Research Institute, University of York, York, UK
The Alan Turing Institute, Kings Cross, London, UK

Search for other papers by Andrew N Holding in
Google Scholar
PubMed Close

Introduction Approximately 75% of breast cancers are classified as estrogen receptor-α (ER) positive. In these cancers, the ER is no longer correctly regulated, subverts cell division regulation, and becomes the driving transcription factor in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-23-0133
Volume/Issue:
Volume 73: Issue 1
Open access