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Miguel Beato Centre de Regulació Genomica (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain

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Roni H G Wright Centre de Regulació Genomica (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, Barcelona, Spain

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François Le Dily Centre de Regulació Genomica (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, Barcelona, Spain

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Introduction The steroid hormone progesterone was initially considered to be involved mainly in menstrual cycle, pregnancy, and mammary gland function. Meanwhile, it was also implicated in multiple other functions outside the sexual organs. In

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-19-0266
Volume/Issue:
Volume 65: Issue 1
Open access
Nathan Appanna Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, Oxfordshire, UK

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Hylton Gibson Department of Biochemistry, Stellenbosch University, Stellenbosch, Western Cape, South Africa

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Elena Gangitano Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, Oxfordshire, UK
Department of Experimental Medicine, Sapienza University of Rome, Rome, Lazio, Italy

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Niall J Dempster Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, Oxfordshire, UK

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Karen Morris Biochemistry Department, Manchester University NHS Trust, Manchester Academic Health Science Centre, Manchester, Greater Manchester, UK

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Sherly George Biochemistry Department, Manchester University NHS Trust, Manchester Academic Health Science Centre, Manchester, Greater Manchester, UK

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Anastasia Arvaniti Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, Oxfordshire, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, Oxfordshire, UK

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Laura L Gathercole Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, Oxfordshire, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, Oxfordshire, UK

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Brian Keevil Biochemistry Department, Manchester University NHS Trust, Manchester Academic Health Science Centre, Manchester, Greater Manchester, UK

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Trevor M Penning Center of Excellence in Environmental Toxicology and Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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Karl-Heinz Storbeck Department of Biochemistry, Stellenbosch University, Stellenbosch, Western Cape, South Africa

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Jeremy W Tomlinson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, Oxfordshire, UK

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Nikolaos Nikolaou Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, Oxfordshire, UK

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Introduction Steroid hormones, including glucocorticoids, androgens and oestrogens, are fat-soluble molecules biosynthesised from cholesterol that play a crucial role in development, differentiation and metabolism ( Simons 2008

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-20-0160
Volume/Issue:
Volume 66: Issue 3
Open access
Robin Haring Institute of Clinical Chemistry and Laboratory Medicine, Interfaculty Institute for Genetics and Functional Genomics, Department of Pharmacology, School of Clinical and Experimental Medicine

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Henri Wallaschofski Institute of Clinical Chemistry and Laboratory Medicine, Interfaculty Institute for Genetics and Functional Genomics, Department of Pharmacology, School of Clinical and Experimental Medicine

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Alexander Teumer Institute of Clinical Chemistry and Laboratory Medicine, Interfaculty Institute for Genetics and Functional Genomics, Department of Pharmacology, School of Clinical and Experimental Medicine

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Heyo Kroemer Institute of Clinical Chemistry and Laboratory Medicine, Interfaculty Institute for Genetics and Functional Genomics, Department of Pharmacology, School of Clinical and Experimental Medicine

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Angela E Taylor Institute of Clinical Chemistry and Laboratory Medicine, Interfaculty Institute for Genetics and Functional Genomics, Department of Pharmacology, School of Clinical and Experimental Medicine

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Cedric H L Shackleton Institute of Clinical Chemistry and Laboratory Medicine, Interfaculty Institute for Genetics and Functional Genomics, Department of Pharmacology, School of Clinical and Experimental Medicine

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Matthias Nauck Institute of Clinical Chemistry and Laboratory Medicine, Interfaculty Institute for Genetics and Functional Genomics, Department of Pharmacology, School of Clinical and Experimental Medicine

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Uwe Völker Institute of Clinical Chemistry and Laboratory Medicine, Interfaculty Institute for Genetics and Functional Genomics, Department of Pharmacology, School of Clinical and Experimental Medicine

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Georg Homuth Institute of Clinical Chemistry and Laboratory Medicine, Interfaculty Institute for Genetics and Functional Genomics, Department of Pharmacology, School of Clinical and Experimental Medicine

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Wiebke Arlt Institute of Clinical Chemistry and Laboratory Medicine, Interfaculty Institute for Genetics and Functional Genomics, Department of Pharmacology, School of Clinical and Experimental Medicine

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Introduction DHEAS is the most abundant steroid in human circulation and represents the conjugated, nonactive excretion form of DHEA, which acts as the universal sex steroid precursor and the major source of androgens in women ( Arlt et al . 1999

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0185
Volume/Issue:
Volume 50: Issue 1
Open access
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Yasmine Hachemi Institute of Comparative Molecular Endocrinology, Ulm University, Ulm, Germany

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Anna E Rapp Institute of Orthopaedic Research and Biomechanics, Ulm University Medical Centre, Ulm, Germany

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Ann-Kristin Picke Institute of Comparative Molecular Endocrinology, Ulm University, Ulm, Germany

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Gilbert Weidinger Institute of Biochemistry and Molecular Biology, Ulm University, Ulm, Germany

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Anita Ignatius Institute of Orthopaedic Research and Biomechanics, Ulm University Medical Centre, Ulm, Germany

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Jan Tuckermann Institute of Comparative Molecular Endocrinology, Ulm University, Ulm, Germany

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(CRF), which in turn acts on the pituitary, stimulating its release of adrenocorticotropic hormone (ACTH). ACTH acts on the zona fasciculata of the adrenal cortex for the release of GCs, which belong to the steroid class of hormones. Cortisol as the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-18-0024
Volume/Issue:
Volume 61: Issue 1
Open access
Isabelle Durrer Department of Nephrology and Hypertension University of Bern, Berne, Switzerland

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Daniel Ackermann Department of Nephrology and Hypertension University of Bern, Berne, Switzerland

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Rahel Klossner Department of Nephrology and Hypertension University of Bern, Berne, Switzerland
Department of Internal Medicine, Sonnenhof, Lindenhofgruppe, Berne, Switzerland

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Michael Grössl Department of Nephrology and Hypertension University of Bern, Berne, Switzerland

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Clarissa Vögel Department of Nephrology and Hypertension University of Bern, Berne, Switzerland

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Therina Du Toit Department for BioMedical Research University of Bern, Berne, Switzerland

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Bruno Vogt Department of Nephrology and Hypertension University of Bern, Berne, Switzerland

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Heidi Jamin Department of Nephrology and Hypertension University of Bern, Berne, Switzerland
Department for BioMedical Research University of Bern, Berne, Switzerland

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Markus G Mohaupt Department of Internal Medicine, Sonnenhof, Lindenhofgruppe, Berne, Switzerland
Department for BioMedical Research University of Bern, Berne, Switzerland

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Carine Gennari-Moser Department of Nephrology and Hypertension University of Bern, Berne, Switzerland
Department for BioMedical Research University of Bern, Berne, Switzerland

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added with the steroid hormone substrates progesterone, DOC, corticosterone or 18-OH-corticosterone at a concentration of 10 −6 M and with or without AngII (10 −6 M). After 24 h, the supernatant was collected for LC-MS analysis and total RNA extraction

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-23-0100
Volume/Issue:
Volume 72: Issue 3
Open access
Marc Simard Department of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada

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Caroline Underhill Department of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada

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Geoffrey L Hammond Department of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada

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.01.005 ) 10.1016/j.mce.2014.01.005 24424442 Lin HY Muller YA Hammond GL 2010 Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin . Molecular and Cellular Endocrinology 316 3 – 12 . ( https

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0234
Volume/Issue:
Volume 60: Issue 2
Open access
Douglas A Gibson MRC Centre for Inflammation Research, The University of Edinburgh, QMRI, Edinburgh, UK

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Paul A Foster Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK.

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Ioannis Simitsidellis MRC Centre for Inflammation Research, The University of Edinburgh, QMRI, Edinburgh, UK

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Hilary O D Critchley MRC Centre for Reproductive Health, The University of Edinburgh, QMRI, Edinburgh, UK

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Olympia Kelepouri MRC Centre for Inflammation Research, The University of Edinburgh, QMRI, Edinburgh, UK

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Frances Collins MRC Centre for Inflammation Research, The University of Edinburgh, QMRI, Edinburgh, UK

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Philippa T K Saunders MRC Centre for Inflammation Research, The University of Edinburgh, QMRI, Edinburgh, UK

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responses consistent with stromal utilisation of sulphated steroids as precursors to active hormones during decidualisation. Elucidation of the complex intracrine metabolism of steroids within the endometrium during decidualisation will be critical to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-18-0037
Volume/Issue:
Volume 61: Issue 2
Open access
Simak Ali Department of Surgery & Cancer, Imperial College London, London, UK

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Kirsty Balachandran Department of Surgery & Cancer, Imperial College London, London, UK

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Bert O’Malley Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA

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The beginning of the twentieth century saw a transformation in the field of endocrinology. Prominent among the many seminal discoveries was the identification and subsequent purification of ovarian steroid hormones, estrogen and progesterone. It

Article Type:
Editorial
DOI:
https://doi.org/10.1530/JME-20-0145
Volume/Issue:
Volume 65: Issue 1
Open access
Deyana Ivanova Department of Women and Children’s Health, Faculty of Life Science and Medicine, King’s College London, UK
Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Kevin T O’Byrne Department of Women and Children’s Health, Faculty of Life Science and Medicine, King’s College London, UK

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the steroid hormone negative feedback regulation of GnRH pulse generation in the ewe ( Goodman et al. 1995 ). Although, other early reports conducted in humans concluded that endogenous opioid peptide signalling is somewhat involved in the regulation

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-23-0079
Volume/Issue:
Volume 72: Issue 2
Open access
T Traboulsi Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec, Canada
Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Québec, Canada

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M El Ezzy Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec, Canada

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J L Gleason Department of Chemistry, McGill University, Montréal, Québec, Canada

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S Mader Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec, Canada
Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Québec, Canada

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,384 reduces cellular estrogen receptor content by increasing its turnover . PNAS 89 4037 – 4041 . ( doi:10.1073/pnas.89.9.4037 ) Davies P Syne JS Nicholson RI 1979 Effects of estradiol and the antiestrogen tamoxifen on steroid hormone

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-16-0024
Volume/Issue:
Volume 58: Issue 1
Open access