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Yihong Wan Department of Pharmacology, Gene Expression Laboratory, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Room ND8.502B, Dallas, Texas 75390-9041, USA
Department of Pharmacology, Gene Expression Laboratory, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Room ND8.502B, Dallas, Texas 75390-9041, USA

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Ronald M Evans Department of Pharmacology, Gene Expression Laboratory, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Room ND8.502B, Dallas, Texas 75390-9041, USA

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responses. Accumulating evidence in both clinical studies and animal disease models has shown that FKN signaling is also involved in the pathogenesis of various chronic inflammatory diseases, such as atherosclerosis ( Lesnik et al . 2003 ), age

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-09-0090
Volume/Issue:
Volume 44: Issue 2
Open access
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Abigail R Walker Institute of Reproductive and Developmental Biology, Department Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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Holly A Parkin Institute of Reproductive and Developmental Biology, Department Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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Sung Hye Kim Institute of Reproductive and Developmental Biology, Department Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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Vasso Terzidou Institute of Reproductive and Developmental Biology, Department Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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David F Woodward Department of Bioengineering, Imperial College London, London, UK

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Phillip R Bennett Institute of Reproductive and Developmental Biology, Department Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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Aylin C Hanyaloglu Institute of Reproductive and Developmental Biology, Department Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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internalisation is no longer accepted as synonymous with signal termination. In contrast, receptors can signal not only from the plasma membrane but from distinct subcellular compartments, including early endosomes ( Jean-Alphonse et al. 2014 , Irannejad et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-23-0153
Volume/Issue:
Volume 73: Issue 1
Open access
S Das Bone and Musculoskeletal Research Programme, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

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I Sepahi Bone and Musculoskeletal Research Programme, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

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A Duthie Bone and Musculoskeletal Research Programme, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

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S Clark Bone and Musculoskeletal Research Programme, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

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J C Crockett Bone and Musculoskeletal Research Programme, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

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the activation of downstream signal transduction ( Tartaglia & Goeddel 1992 ). Subsequently, it was established that TNFR could also self-assemble into trimers when overexpressed in the absence of ligand ( Boldin et al . 1995 ). These findings led to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-14-0077
Volume/Issue:
Volume 53: Issue 1
Open access
Megan Beetch Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Brian Akhaphong Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Alicia Wong Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Briana Clifton Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Seokwon Jo Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Ramkumar Mohan Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Juan E Abrahante Llorens University of Minnesota Informatics Institute (UMII), Minneapolis, Minnesota, USA

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Emilyn U Alejandro Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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to support fetal growth, responds to maternal nutrient availability and fetal demand to orchestrate the allocation of nutrients to meet energy and nutritional needs. Placental signaling pathways regulate fetal growth by sensing and integrating

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-23-0035
Volume/Issue:
Volume 71: Issue 4
Open access
Selina Mäkinen Minerva Foundation Institute for Medical Research, Tukholmankatu, Helsinki, Finland
Department of Medicine, University of Helsinki and Helsinki University Hospital, Haartmaninkatu, Helsinki, Finland

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Neeta Datta Minerva Foundation Institute for Medical Research, Tukholmankatu, Helsinki, Finland
Department of Medicine, University of Helsinki and Helsinki University Hospital, Haartmaninkatu, Helsinki, Finland

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Savithri Rangarajan Pam Gene International B.V., Wolvenhoek, BJ ´s-Hertogenbosch, The Netherlands

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Yen H Nguyen Minerva Foundation Institute for Medical Research, Tukholmankatu, Helsinki, Finland
Department of Medicine, University of Helsinki and Helsinki University Hospital, Haartmaninkatu, Helsinki, Finland

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Vesa M Olkkonen Minerva Foundation Institute for Medical Research, Tukholmankatu, Helsinki, Finland
Department of Anatomy, Faculty of Medicine, Haartmaninkatu, University of Helsinki, Helsinki, Finland

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Aino Latva-Rasku Turku PET Centre, University of Turku, Kiinamyllynkatu, Turku, Finland
Turku PET Centre, Turku University Hospital, Kiinamyllynkatu, Turku, Finland

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Pirjo Nuutila Turku PET Centre, University of Turku, Kiinamyllynkatu, Turku, Finland
Turku PET Centre, Turku University Hospital, Kiinamyllynkatu, Turku, Finland

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Markku Laakso Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Puijonlaaksontie, Kuopio, Finland

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Heikki A Koistinen Minerva Foundation Institute for Medical Research, Tukholmankatu, Helsinki, Finland
Department of Medicine, University of Helsinki and Helsinki University Hospital, Haartmaninkatu, Helsinki, Finland

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Introduction Genetic variants in the insulin signalling pathway contribute to increased risk for type 2 diabetes ( Manning et al. 2012 , 2017 ). One example of an insulin resistance-associated gene is a missense variant p.P50T of AKT2

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-21-0285
Volume/Issue:
Volume 70: Issue 2
Open access
Caroline M Gorvin Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Oxford NIHR Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Institute of Metabolism and Systems Research (IMSR) & Centre for Endocrinology, Diabetes and Metabolism (CEDAM), Birmingham Health Partners, University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK

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Paul J Newey Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Division of Molecular & Clinical Medicine (MCM), University of Dundee, Jacqui Wood Cancer Centre, Dundee, UK

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Rajesh V Thakker Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Oxford NIHR Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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potentially, simultaneous interaction with multiple signalling kinases ( Haxholm et al. 2015 , Bugge et al. 2016 ). Hormone binding to the ECD activates conformational changes within the TMD and ICD, allowing separation of the ICDs and initiating

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-22-0164
Volume/Issue:
Volume 70: Issue 3
Open access
Rikus Botha Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand

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Shree S Kumar Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand

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Natasha L Grimsey Department of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand
Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand
Maurice Wilkins Centre for Biodiscovery, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand

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Kathleen G Mountjoy Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand
Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand
Maurice Wilkins Centre for Biodiscovery, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand
Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag, Auckland, New Zealand

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did not measure a physiological response ( Gillyard et al. 2019 ). Therefore, after two decades, no study has elucidated how the human MC4R (hMC4R) signals to regulate body weight. A new approach is needed. Surprisingly, six hMC4R variants with

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-23-0008
Volume/Issue:
Volume 71: Issue 1
Open access
James G Yarger
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Robert E Babine ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

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Michael Bittner ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

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Erin Shanle ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

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Wei Xu ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

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Pamela Hershberger ENDECE, Rebexsess Discovery Chemistry, Translational Genomics Research Institute, McArdle Laboratory for Cancer Research, Roswell Park Cancer Institute, LLC, 1001 West Glen Oaks Lane, Suite 105B, Mequon, Wisconsin 53092, USA

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Steven H Nye
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.05. For the DNA microarray studies, significant ( P <0.001) up- or downregulated genes were identified by comparing the E 2 analog-treated and vehicle-treated samples from each tumor cell line. Genes were included in the relevant signaling pathways

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0083
Volume/Issue:
Volume 50: Issue 1
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Hsien-Ming Wu Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University School of Medicine, Taoyuan, Taiwan

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Liang-Hsuan Chen Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University School of Medicine, Taoyuan, Taiwan

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Wei-Jung Chiu Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University School of Medicine, Taoyuan, Taiwan

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Chia-Lung Tsai Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University School of Medicine, Taoyuan, Taiwan

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extensive investigation of LIF–STAT and integrin signaling may improve the outcome of embryo implantation and subsequent pregnancy. In this study, we have tried to identify extracted EVs and miRNAs from decidua and decidual stromal cells. miRNA

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-24-0006
Volume/Issue:
Volume 73: Issue 2
Open access
Shalinee Dhayal Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

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Kaiyven Afi Leslie Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

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Mohammad Baity Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

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Pouria Akhbari Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

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Sarah J Richardson Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

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Mark A Russell Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

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Noel G Morgan Islet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK

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et al. 2018 , 2020 ). Thus, as type 1 diabetes progresses, pancreatic β-cells are exposed to a variety of IFNs and, to marshal an effective response, the cells must interpret and integrate these input signals effectively. The signal transduction

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-21-0224
Volume/Issue:
Volume 69: Issue 2
Open access