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Open access

Fadil M Hannan, Valerie N Babinsky, and Rajesh V Thakker

G proteins and other components of the CaSR signal transduction pathway ( Leach et al . 2012 ). Some loss-of-function CaSR mutations have been shown to cause signalling bias by switching the wild-type CaSR from preferentially coupling with

Open access

Jun Zhou, Qilong Wang, Ye Ding, and Ming-Hui Zou

resistance remain to be determined. The insulin signaling transduction cascade initiated by insulin binding to its receptor causing receptor autophosphorylation and tyrosine phosphorylation of insulin receptor substrate 1 (IRS1) subsequently activating

Open access

Ying Ying, Huazhang Zhu, Zhen Liang, Xiaosong Ma, and Shiwei Li

metabolism . Biochimica et Biophysica Acta 1044 1 – 12 . ( doi:10.1016/0005-2760(90)90211-F ). Miller JR Hocking AM Brown JD Moon RT 1999 Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca 2+ pathways . Oncogene

Open access

Zhi Zhang, Fang Wang, Bing-jian Wang, Guang Chu, Qunan Cao, Bao-Gui Sun, and Qiu-Yan Dai

-antagonist function of adiponectin in our 3D vessel model in order to elucidate the effects of receptors and the underlying signal transduction pathways of adiponectin. Materials and methods Preparation of HUVECs and HUASMCs The present study was approved by the

Open access

J M Young and A S McNeilly

signal transduction of BMP (Smad1/5/8), or BMP and activin (Smad2/3) signaling respectively. These inhibitory factors were transfected into theca cultures using adenoviruses to manipulate Smad signal transduction specifically. To establish the rate of

Open access

S Das, I Sepahi, A Duthie, S Clark, and J C Crockett

the activation of downstream signal transduction ( Tartaglia & Goeddel 1992 ). Subsequently, it was established that TNFR could also self-assemble into trimers when overexpressed in the absence of ligand ( Boldin et al . 1995 ). These findings led to

Open access

Elizabeth M Pritchett, Susan J Lamont, and Carl J Schmidt

Test, is indicated by color. Blue is not significant while yellow to maroon is P -value 0.05–0.0001, respectively. DB, developmental biology; NS, neuronal system; ST, significant pathways are signal transduction; Ttos, transmembrane transport of small

Open access

Yihong Wan and Ronald M Evans

all the experiments, n =3; **indicates P <0.01. Rosiglitazone activation of PPARγ disrupts the membrane translocation of FR in macrophages The function of the FR requires its plasma membrane translocation for ligand binding and signal transduction

Open access

Indrajit Chowdhury, Kelwyn Thomas, Anthony Zeleznik, and Winston E Thompson

) Amsterdam A Tajima K Frajese V Seger R 2003 Analysis of signal transduction stimulated by gonadotropins in granulosa cells . Molecular and Cellular Endocrinology 202 77 – 80 . ( doi:10.1016/S0303-7207(03)00066-2 ) Ande SR Gu Y

Open access

Patricia Carrasco, Iratxe Zuazo-Gaztelu, and Oriol Casanovas

tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors . American Journal of Pathology 151 1523 – 1530 . Picard O Rolland Y Poupon MF 1986 Fibroblast-dependent tumorigenicity of