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Open access

Rodolfo Niño Fong, Zahra Fatehi-Hassanabad, Simon C Lee, Hongfang Lu, Michael B Wheeler and Catherine B Chan

is still unclear. In pancreatic β-cells, increased UCP2 expression is associated with suppression of glucose-stimulated insulin secretion ( Chan et al . 1999 , 2001 ) and mediates the negative effects of superoxide on insulin secretion ( Krauss et

Open access

Gemma Tan, Andrew G Elefanty and Edouard G Stanley

place of donor-derived pancreatic tissue. Of particular interest are pluripotent stem cells, immortal stable cell lines that can be differentiated into any cell type found in the body, including insulin-producing β-cells. This review briefly discusses

Open access

Daniela Nasteska and David J Hodson

-dependent periodic activation of a Ca2+-activated K+ conductance in glucose-stimulated pancreatic β-cells . Nature 353 849 – 852 . 10.1038/353849a0 Anisimova M García-Ortega LF Martínez O 2015 How many genes are expressed in a transcriptome

Open access

Yan Zheng and Kevin D Houston

pancreatic cells ( Johnston 1999 ). D-glucose deprivation can also induce the expression of genes such as heme oxygenase-1 ( Chang et al. 2002 ) and interleukin 6 ( Choi et al. 2013 ). Furthermore, in D-glucose-deprived cells, AMP-activated protein kinase

Open access

James G Yarger, Robert E Babine, Michael Bittner, Erin Shanle, Wei Xu, Pamela Hershberger and Steven H Nye

ER-α positive, ER-β positive pancreatic tumor cell line ( Mariani 2005 ). SK-OV-3 is an ER-α positive, ER-β positive ovarian tumor cell line; however, there is a 32-bp deletion in ER-α rendering it nonfunctional ( Lau et al . 1999 ). Cells were

Open access

Patricia Carrasco, Iratxe Zuazo-Gaztelu and Oriol Casanovas

insulin-producing beta cells of the pancreatic islets into islet cell carcinomas. Therefore, normal islets express the Tag oncogene, and RIP1-Tag2 mice are morphologically asymptomatic until 3–4 weeks of age. Hyperplasic islets start to arise

Open access

Ying Ying, Huazhang Zhu, Zhen Liang, Xiaosong Ma and Shiwei Li

Myers MG Jr Rhodes CJ 2001 Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic β-cell line INS-1 . Endocrinology 142 229 – 240 . ( doi:10.1210/endo.142

Open access

Tingyuan Ren, Yuping Zhu, Xuejuan Xia, Yongbo Ding, Jing Guo and Jianquan Kan

PI3K/PTEN/AKT/mTOR pathway in treatment of sarcoma cell lines . Anticancer Research 36 5765 – 5771 . ( doi:10.21873/anticanres.11160 ) Lin Y Sun Z 2015 Antiaging gene klotho attenuates pancreatic β-cell apoptosis in type 1 diabetes

Open access

Yoshihiro Suzuki, Keiko Nakahara, Keisuke Maruyama, Rieko Okame, Takuya Ensho, Yoshiyuki Inoue and Noboru Murakami

tissue (WAT). In addition, synthesis of leptin occurs in brown adipose tissue, liver, skeletal muscle, the gastric fundus, placenta, ovary, mammary epithelial cells, bone marrow, pituitary gland, and hypothalamus ( Morash et al . 1999 ). The effects of