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Open access

Yan Zheng and Kevin D Houston

impaired glucose tolerance within 6 months of age ( Martensson et al. 2009 ). Of note, both classical and non-classical estrogen signaling regulates glucose uptake, glucose storage, insulin secretion and has a role in insulin sensitivity ( Brown & Clegg

Open access

Lingyun Zhang, Takashi Sugiyama, Nao Murabayashi, Takashi Umekawa, Ning Ma, Yuki Kamimoto, Yoshihiro Ogawa, and Norimasa Sagawa

% paraformaldehyde (Nakarai Tesque, Kyoto, Japan), and the other tissues were frozen in liquid nitrogen and stored at −80 °C prior to RNA extraction. Metabolic testing For glucose tolerance test (GTT), the mice were deprived of food for 14–16 h overnight and then

Open access

Rihua Zhang, Dongming Su, Weidong Zhu, Qiong Huang, Menglan Liu, Yi Xue, Yuanyuan Zhang, Dong li, Allan Zhao, and Yun Liu

tolerance test Fourteen weeks after the E 2 treatment, IPGTT was conducted. All rats were starved for 12 h, and then their tail blood glucose concentrations (mM) were monitored using a handheld glucometer (ACCU-CHEK Performa, Roche). Blood was collected

Open access

Jian-Hua Chen, Maria Segni, Felicity Payne, Isabel Huang-Doran, Alison Sleigh, Claire Adams, UK10K Consortium, David B Savage, Stephen O'Rahilly, Robert K Semple, and Inês Barroso

. 2006 ). Other analytes were determined in accredited clinical diagnostic laboratories of the referring hospital. For oral glucose tolerance testing, 1.75 g glucose/kg was administered after a 10 h fast and blood samples taken at the times indicated for

Open access

Daniela Nasteska and David J Hodson

recently reported interplay between Ca 2+ influx and gene networks ( Stancill et al . 2017 ). Third, ChR2 and eNpHR3.0 significantly improved glucose tolerance in vivo without illumination ( Reinbothe et al . 2014 , Johnston et al . 2016 ), an effect

Open access

Irit Hochberg, Innocence Harvey, Quynh T Tran, Erin J Stephenson, Ariel L Barkan, Alan R Saltiel, William F Chandler, and Dave Bridges

sensitivity, we performed insulin tolerance tests on these mice after 12 weeks of dexamethasone treatment and found that while they had reduced fasting glucose at this stage, they were resistant to insulin-induced reductions in blood glucose ( Fig. 2 E). On

Open access

Gemma Tan, Andrew G Elefanty, and Edouard G Stanley

Wolters GH Van Schilfgaarde R 1991 Glucose tolerance and plasma insulin response to intravenous glucose infusion and test meal in rats with microencapsulated islet allografts . Diabetologia 34 542 – 547 . ( doi:10.1007/BF00400270

Open access

Hyon-Seung Yi, Joon Young Chang, and Minho Shong

diabetic nephropathy ( Huang et al . 2006 ). Muscle- or liver-specific deletion of mitochondrial flavoprotein apoptosis inducing factor results in OxPhos deficiency, but leads to the improvement of glucose tolerance and insulin sensitivity in mice

Open access

Tingyuan Ren, Yuping Zhu, Xuejuan Xia, Yongbo Ding, Jing Guo, and Jianquan Kan

was improved by alkylamides (Yu 2015). In addition, fasting blood glucose and plasma fructose levels significantly decreased in diabetic rats, and oral glucose tolerance was improved. Total cholesterol (TC) and triglyceride (TG) levels in the plasma

Open access

Ting Xiao, Xiuci Liang, Hailan Liu, Feng Zhang, Wen Meng, and Fang Hu

sensitivity and mitochondrial HSP60 level, which resulted in improved glucose tolerance in the adipocytes of ob/ob mice ( Wilson-Fritch et al . 2004 ), suggesting that mitochondrial HSP60, in the UPR mt pathway, may have distinct functions in different