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Open access

Silvia Ottaviani, Greg N Brooke, Ciara O'Hanlon-Brown, Jonathan Waxman, Simak Ali, and Laki Buluwela

-known androgen-regulated genes PSA , NDRG1 and TMPRSS2 was evaluated and up-regulation of their transcripts following androgen treatment was confirmed ( Fig. 1B, C , and D). In addition, androgen-dependent up-regulation of GNMT in LNCaP cells was also shown

Open access

Miguel Beato, Roni H G Wright, and François Le Dily

this review we will concentrate on the role of progestins (Pg) on the regulation of gene expression via their specific progesterone receptor (PR), focusing on breast cancer cells. All the steroid hormone receptors share a similar organization of domains

Open access

Cristina L Esteves, Val Kelly, Valérie Bégay, Simon G Lillico, Achim Leutz, Jonathan R Seckl, and Karen E Chapman

DOX. Elevation of C/EBPβ-LIP in mature differentiated 3T3-L1 adipocytes concomitantly decreased PEPCK and 11β-HSD1 mRNA levels, suggesting direct regulation of 11β-HSD1 by C/EBPβ-LIP in adipocytes. Indeed, both genes are bound by C/EBPβ and this has

Open access

Rodolfo Niño Fong, Zahra Fatehi-Hassanabad, Simon C Lee, Hongfang Lu, Michael B Wheeler, and Catherine B Chan

low concentrations of NO can act in signaling pathways, having been shown to promote insulin secretion via modulation of ATP-dependent K channels ( Sunouchi et al . 2008 ). NO is implicated in the regulation of gene transcription, working via NF

Open access

Richard Barbuto and Jane Mitchell

of the mouse pro-α1(V) collagen gene (Col5a1) in osteoblastic cells . Matrix Biology 29 701 – 706 . ( doi:10.1016/j.matbio.2010.09.002 ). Zhen X Wei L Wu Q Zhang Y Chen Q 2001 Mitogen-activated protein kinase p38 mediates regulation

Open access

Douglas A Gibson, Paul A Foster, Ioannis Simitsidellis, Hilary O D Critchley, Olympia Kelepouri, Frances Collins, and Philippa T K Saunders

current study, we sought to complement and extend our previous investigations by assessing the contribution of STS to intracrine regulation of decidualisation. We used an in vitro model of decidualisation to assess the expression of genes associated with

Open access

Jo E Lewis, John M Brameld, Phil Hill, Dana Wilson, Perry Barrett, Francis J P Ebling, and Preeti H Jethwa

from those governing short-term homeostatic regulation of appetite ( Ebling 2015 ). The expression of a number of genes has been shown to be altered in the ventral ependymal wall lining the hypothalamic third ventricle of Siberian hamsters housed in

Open access

H H Farman, J Wu, K L Gustafsson, S H Windahl, S H Kim, J A Katzenellenbogen, C Ohlsson, and M K Lagerquist

Katzenellenbogen BS 2008 Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors . Molecular Endocrinology 22 2116 – 2127 . ( doi:10.1210/me.2008-0059 ) Manolagas SC O’Brien CA Almeida M

Open access

Elizabeth M Pritchett, Susan J Lamont, and Carl J Schmidt

(43 genes). More specific GO terms associated with the 295 shared genes are neuron cell–cell adhesion (4 genes), oligodendrocyte differentiation (8 genes) and regulation of gliogenesis (9 genes). Figure 2 shows PathRings output for 295 shared genes

Open access

Irina G Bogdarina, Peter J King, and Adrian J L Clark

mediates repression of AP-1-dependent genes in the skin . Journal of Cell Biology 147 1365 – 1370 . Vasanthi D Mishra RK 2008 Epigenetic regulation of genes during development: a conserved theme from flies to mammals . Journal of Genetics and