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Fadil M Hannan, Valerie N Babinsky and Rajesh V Thakker

that comprises the calcium-sensing receptor (CaSR), G-protein α-11 (Gα 11 ) subunit and adaptor-related protein complex 2 sigma (AP2σ) subunit ( Pollak et al . 1993 , Nesbit et al . 2013 a , b ). This article will provide an overview of the role of

Open access

Dan Hanson, Adam Stevens, Philip G Murray, Graeme C M Black and Peter E Clayton

family (TCP1, CCT2, CCT3 and CCT6A) were present in the 3-M interactome and predict they may act as adaptor proteins within the CUL7 SCF complex. IP experiments from lysates of HEK293 cells overexpressing CUL7, V5-OBSL1 and CCDC8 confirmed the interaction

Open access

H H Farman, J Wu, K L Gustafsson, S H Windahl, S H Kim, J A Katzenellenbogen, C Ohlsson and M K Lagerquist

-terminal of the receptor, can bind several coregulatory proteins, but is less well characterized compared to the AF-2 domain. We have previously demonstrated that ERαAF-2 is required for estrogenic responses in all tissues evaluated, whereas the role of ERαAF

Open access

Oro Uchenunu, Michael Pollak, Ivan Topisirovic and Laura Hulea

complex 2; MAPK, mitogen-activated protein kinase; RSK, p90 ribosomal S6 kinase; DDIT4, DNA damage inducible transcript 4; AKT, protein kinase B; AMPK, AMP-activated protein kinase; RHEB, ras homolog, MTORC1 binding; LAMTOR, late endosomal and lysosomal

Open access

Farhana Naznin, Koji Toshinai, T M Zaved Waise, Tadashi Okada, Hideyuki Sakoda and Masamitsu Nakazato

expressing the orexigenic neuropeptides agouti-related peptide (AgRP) and neuropeptide Y (NPY) ( Date et al . 2006 ). GHSR, a G-protein-coupled receptor, activates the intracellular Ca 2+ signaling and AMP-activated protein kinase (AMPK) signaling pathways

Open access

Karine Rizzoti

a repressor of Wnt activity. Conditional mutation is now required to assess its function directly. PITX1/PITX2 The paired homoeodomain PITX proteins are important morphogenetic regulators for different organs. They are also well known for their role

Open access

Patricia Carrasco, Iratxe Zuazo-Gaztelu and Oriol Casanovas

vasoactive intestinal polypeptide ( Massironi et al . 2008 ). Related to their pathological grade and state of differentiation and aggressiveness, NETs are divided into three different groups: low grade (G1), intermediate grade (G2) and high-grade tumors (G3