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Fraydoon Rastinejad Nuffield Department of Medicine, University of Oxford, Target Discovery Institute (NDM RB), Oxford, UK

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Introduction The retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are the earliest and most intensely studied nuclear receptors (NRs) for their three-dimensional (3D) structures. Both receptor groups bind to retinoic acids (RAs

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Jo E Lewis Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK
Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK

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John M Brameld Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK

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Phil Hill Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK

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Dana Wilson Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK

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Perry Barrett Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK

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Francis J P Ebling Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK

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Preeti H Jethwa Division of Nutritional Sciences, School of Life Sciences, The Rowett Institute of Nutrition and Health, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK

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-binding protein-2 (CRABP-2) and the nuclear receptors, RAR and RXR) is reduced in response to SD in the Siberian hamster ( Ross et al . 2005 , Barrett et al . 2006 ), so this may explain why VGF mRNA expression is reduced in the hypothalamus of Siberian

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Douglas R Houston Institute of Quantitative Biology, Biochemistry, and Biotechnology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK

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Jane G Hanna Institute of Quantitative Biology, Biochemistry, and Biotechnology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK

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J Constance Lathe Program in Neuroscience, University of Glasgow, Glasgow, UK

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Stephen G Hillier Medical Research Council Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Richard Lathe Division of Infection Medicine, University of Edinburgh, Edinburgh, UK

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>3.0.CO;2-H ) 9095674 Nakshatri H Chambon P 1994 The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers . Journal of

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