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Open access

Fadil M Hannan, Valerie N Babinsky and Rajesh V Thakker

G proteins and other components of the CaSR signal transduction pathway ( Leach et al . 2012 ). Some loss-of-function CaSR mutations have been shown to cause signalling bias by switching the wild-type CaSR from preferentially coupling with

Open access

Zhi Zhang, Fang Wang, Bing-jian Wang, Guang Chu, Qunan Cao, Bao-Gui Sun and Qiu-Yan Dai

-antagonist function of adiponectin in our 3D vessel model in order to elucidate the effects of receptors and the underlying signal transduction pathways of adiponectin. Materials and methods Preparation of HUVECs and HUASMCs The present study was approved by the

Open access

J M Young and A S McNeilly

signal transduction of BMP (Smad1/5/8), or BMP and activin (Smad2/3) signaling respectively. These inhibitory factors were transfected into theca cultures using adenoviruses to manipulate Smad signal transduction specifically. To establish the rate of

Open access

Elizabeth M Pritchett, Susan J Lamont and Carl J Schmidt

Test, is indicated by color. Blue is not significant while yellow to maroon is P -value 0.05–0.0001, respectively. DB, developmental biology; NS, neuronal system; ST, significant pathways are signal transduction; Ttos, transmembrane transport of small

Open access

Jun Zhou, Qilong Wang, Ye Ding and Ming-Hui Zou

resistance remain to be determined. The insulin signaling transduction cascade initiated by insulin binding to its receptor causing receptor autophosphorylation and tyrosine phosphorylation of insulin receptor substrate 1 (IRS1) subsequently activating

Open access

S Das, I Sepahi, A Duthie, S Clark and J C Crockett

the activation of downstream signal transduction ( Tartaglia & Goeddel 1992 ). Subsequently, it was established that TNFR could also self-assemble into trimers when overexpressed in the absence of ligand ( Boldin et al . 1995 ). These findings led to

Open access

M H Abel, D Baban, S Lee, H M Charlton and P J O'Shaughnessy

-signalling family which are GTPase-activating proteins that act to inhibit signal transduction and thus play a role in desensitisation ( Chasse & Dohlman 2003 ). The role of RGSs in normal hormonal signalling is not well established but the declining levels of Rgs

Open access

Ross S Thomas, Naveed Sarwar, Fladia Phoenix, R Charles Coombes and Simak Ali

distinct signal transduction pathways revealed by phosphorylation-specific antisera . Oncogene 21 4921 – 4931 . Couse JF Korach KS 1999 Estrogen receptor null mice: what have we learned and where will they lead us? Endocrine

Open access

Yihong Wan and Ronald M Evans

all the experiments, n =3; **indicates P <0.01. Rosiglitazone activation of PPARγ disrupts the membrane translocation of FR in macrophages The function of the FR requires its plasma membrane translocation for ligand binding and signal transduction

Open access

Richard Barbuto and Jane Mitchell

.123612 ). Raingeaud J Whitmarsh AJ Barrett T Derijard B Davis RJ 1996 MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway . Molecular and Cellular Biology 16 1247 – 1255 . Rey