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Daniela Nasteska and David J Hodson

tissue from donors. However, studies using matrix-assisted laser desorption ionisation (MALDI) imaging in fixed tissue, together with in vitro experiments, demonstrated that stearoylcarnitine accumulated in beta cells to arrest insulin synthesis, while

Open access

Oro Uchenunu, Michael Pollak, Ivan Topisirovic and Laura Hulea

, hyperlipidemia, a decrease in glucose-stimulated insulin synthesis and secretion and weight loss ( Fraenkel et al . 2008 ). Overall, rapamycin suppresses key metabolic processes by inhibiting MTORC1 . Rapamycin and its analogs (rapalogs; Fig. 1 ) are FDA