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border of the neural plate. These involve fibroblast growth factor (FGF) signalling inducing neural fate, bone morphogenetic proteins (BMPs) and wingless-related integration site (WNT) activities inducing future epidermal identity in non-neural ectoderm
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School of Medicine, Department of Geriatric, Shenzhen University Diabetes Center, Shenzhen University, Shenzhen 518060, China
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-induced cardiomyocyte apoptosis remain incompletely clarified. Wnt and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signalling pathways converge through beta-catenin (b-catenin)-mediated regulation of cell survival/apoptosis in different cell types
National Heart and Lung Institute, Imperial College London, London, UK
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and nutrients are exported into the LSECs and liver parenchyma, while metabolism products and other cell exports enter the blood ( Fig. 1 ). This structure creates a gradient of oxygen, nutrients, and signalling molecules including Wnt morphogens, a
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(OCN), and Wnt ligands (7b, 10b) and a simultaneous increase in expression of Wnt signalling inhibitors, including sclerostin (SCL), dickkopf-1 (DKK1), and Wnt-inhibitory factor (WIF1), as well as the adipogenic markers peroxisome proliferator
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interactor 2 13.3 Aqp5 Aquaporin 5 5.03 Pdgfc Platelet-derived growth factor C 12.1 Wif1 Wnt inhibitory factor 1 4.55 Transcribed locus b 11.0 Fabp5 Fatty acid binding protein 5, epidermal 4.53 Bcan Brevican 6.6 Tubb3 Tubulin, β 3 4.46 Rgs11 Regulator of G
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transduction ADORA1, ARHGEF4, CHRDL1, CNTN1, COL9A3, EGF, ERBB4, FZD10, GFAP, GNAO1, GPR17, GREM2, GRM3, GRM7, GRPR, HRH3, NPBWR1, NRG3, NTRK2, PDE4A, PDE8B, RAMP1, WNT11, WNT6, WNT7B Neuronal system CACNG4, CHRNA4, GABRA3, GRIA4, GRIK2, GRIK3, KCNK2
Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China
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. One recent study carried out in mouse focusing on osteogenesis has identified that ITGA11 is an osteolectin receptor, and the Wnt pathway could be activated by the binding of osteolectin to the ITGA11 ( Shen et al. 2019 ). The expression of ITGA11
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Region Västra Götaland, Sahlgrenska University Hospital, Department of Surgery, Gothenburg, Sweden
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Region Västra Götaland, Sahlgrenska University Hospital, Department of Surgery, Gothenburg, Sweden
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. Isolated crypts were seeded, embedded in Matrigel (Corning) in 24-well plates and cultured with Wnt3A-supplemented expansion media (IntestiCult Organoid Growth Media (STEMCELLS, Vancouver, Canada) with 10 μM Y-27632 (Sigma-Aldrich) and 0.1% gentamycin
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-cytokines/lymphocyte enhancers (TCF/LEF) transcriptional activity to activate the Wnt signaling pathway. Further studies are required to determine the molecule mechanism by which VDR interacts with E-cadherin and β-catenin and the relationship between VDR and β-catenin/Wnt
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Fetal Medicine Unit, St. George’s Hospital, London, UK
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decidualisation, including LEFTY2, a NODAL signalling pathway inhibitor, which is highly expressed by decidualising cells, the key transcription factor CCAAT/enhancer-binding protein (C/EPB) and secreted products, such as Wnt5a, Dickkopf 1 (DKK1) and prokinectin