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Oro Uchenunu, Michael Pollak, Ivan Topisirovic and Laura Hulea

/or translational regulation. MTORC1 stimulates nucleotide synthesis (via ATF4), pentose phosphate pathway and lipid biosynthesis (via SREBP1), adipogenesis (via PPARG), glutamine metabolism (via ATF2 and MYC) and mitochondrial biogenesis (via PPARGC1A and YY1). The

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Jian-Hua Chen, Maria Segni, Felicity Payne, Isabel Huang-Doran, Alison Sleigh, Claire Adams, UK10K Consortium, David B Savage, Stephen O'Rahilly, Robert K Semple and Inês Barroso

resistance ( INSR , PIK3R1 , AKT2 , TBC1D4 , LMNA , PPARG , BSCL2 , AGPAT2 , PTRF , CAV1 , PCNT , NSMCE2 , ALMS1 , WRN , and BLM ). After removing any variants found in the listed genes with a non-reference allele frequency >1% in any of the