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Ting Xiao, Xiuci Liang, Hailan Liu, Feng Zhang, Wen Meng and Fang Hu

Introduction Endoplasmic reticulum (ER) stress due to high fat diet (HFD) feeding or genetic obesity is associated with hepatic steatosis and insulin resistance ( Kammoun et al . 2009 , Yoshiuchi et al . 2009 , Ye et al . 2010 , Meng et

Open access

Cristina L Esteves, Val Kelly, Valérie Bégay, Simon G Lillico, Achim Leutz, Jonathan R Seckl and Karen E Chapman

M Qadri I Rahman SM Schroeder-Gloeckler J Janssen RC Friedman JE 2011 C/EBPβ is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells . Molecular and Cellular Endocrinology 331 102 – 108 . ( doi:10

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Daniela Nasteska and David J Hodson

fail are well defined, at least in rodents, and encompass loss of glucose responsiveness, de-differentiation, ER stress and apoptosis, all probably secondary to a combination of glucolipotoxicity and cytotoxicity ( Porte & Kahn 2001 , Prentki & Nolan