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conformational change of this transcription factor, subsequent association with estrogen response elements (ERE) within the promoters of target genes thus promoting gene transcription ( Klinge 2001 ). More recently, non-classical mechanisms of estrogen signaling
Institute of Endocrinology, Life Science Institute, Physiology, Preventive Medicine, Internal Medicine, Neurosurgery, Pediatrics, Diabetes and Metabolism, Rambam Health Care Campus, Haifa, Israel
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Institute of Endocrinology, Life Science Institute, Physiology, Preventive Medicine, Internal Medicine, Neurosurgery, Pediatrics, Diabetes and Metabolism, Rambam Health Care Campus, Haifa, Israel
Institute of Endocrinology, Life Science Institute, Physiology, Preventive Medicine, Internal Medicine, Neurosurgery, Pediatrics, Diabetes and Metabolism, Rambam Health Care Campus, Haifa, Israel
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lipogenesis ( Divertie et al . 1991 , Samra et al . 1998 , Kršek et al . 2006 , Campbell et al . 2011 ). Glucocorticoids, through binding to the glucocorticoid receptor, exert transcriptional induction and repression of numerous genes ( Reddy et al
Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China
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control GAPDH and calculated with the 2 –△△Ct method. Results are means ± s.e.m. of n = 4–8 independent experiments from EndoC-βH1 cells. * indicates P < 0.05. Exogenous rhCLEC11A increases the expression levels of transcription
Universitat Pompeu Fabra (UPF), Barcelona, Spain
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mechanisms that enable the PR to access DNA sequences on chromatin and to modulate the transcriptional rate of subsets of hormone responsive genes. Before going into the more recent results obtained with genome-wide approaches, we will summarize as a
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obesity-related disorders. However, introduction of nucleic acids and, consequently, the manipulation of genes in fully differentiated 3T3-L1 adipocytes are difficult to achieve. pSLIK plasmids, encoding a tetracycline-regulated transcriptional unit in a
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Institute of Metabolism and Systems Research and Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK
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transcription start site (TSS) quality checks. BigWig files were generated using the ‘bamCoverage’ function from deepTools2 software ( Ramirez et al. 2016 ). The reads per genomic content (RPGC) (1× normalisation) approach was used for the coverage
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from Affinity BioReagents (Cambridge, UK) and anti-SP1 rabbit polyclonal antibody (2873-24) – a gift from Prof Steve Jackson, Gurdon Institute, Cambridge, UK. Results Promoter mapping The start site of transcription of the rat Agtr1b gene was
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their functional outputs as transcriptional regulators. The first RAR or RXR domain whose structures were reported were the isolated RARb DBD and RXRα DBD ( Knegtel et al. 1993 , Lee et al. 1994 ). Those NMR structures confirmed that RAR and RXR
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regulates transcription and stability of target genes. GRβ is localized in the nucleus and has a dominant negative effect on GRα through the formation of GRα/GRβ heterodimers. GRP has been reported to have both synergistic and antagonistic effects on GRα
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the nuclear receptor superfamily of ligand-activated transcription factors ( Brinkmann et al . 1999 , Lu et al . 2006 , Dehm & Tindall 2007 ). Following androgen binding, AR dissociates from heat-shock proteins and translocates to the nucleus where