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Open access

Farhana Naznin, Koji Toshinai, T M Zaved Waise, Tadashi Okada, Hideyuki Sakoda, and Masamitsu Nakazato

these DIO experiments used C57BL/6J mice, which develop severe obesity, hyperglycemia and insulin resistance ( Reed et al . 2007 ). Consumption of HFD induces immune cell-mediated tissue inflammation in the gut, adipose tissue, liver, skeletal muscle

Open access

Irit Hochberg, Innocence Harvey, Quynh T Tran, Erin J Stephenson, Ariel L Barkan, Alan R Saltiel, William F Chandler, and Dave Bridges

ceramide species ( Fig. 7 B, q >0.25). Inflammation Several pathways involved in immune function were downregulated in the adipose tissue from Cushing's disease patients. This is consistent with the effects of cortisol in suppressing immune function

Open access

Yihong Wan and Ronald M Evans

PPARδ to inhibit FKN transcription. Emerging evidence reveals that PPARγ is a key regulator of both lipid metabolism and inflammation. The ability to integrate metabolic signaling and inflammatory signaling makes PPARγ an attractive target for

Open access

Lingyun Zhang, Takashi Sugiyama, Nao Murabayashi, Takashi Umekawa, Ning Ma, Yuki Kamimoto, Yoshihiro Ogawa, and Norimasa Sagawa

Investigation 116 1494 – 1505 . doi:10.1172/JCI26498 . Kawanishi N Yano H Yokogawa Y Suzuki K 2010 Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching

Open access

Yasmine Hachemi, Anna E Rapp, Ann-Kristin Picke, Gilbert Weidinger, Anita Ignatius, and Jan Tuckermann

acute and chronic inflammation as well as pain. In addition, they are components of certain cancer therapies. High GC doses resulting from corticosteroid or from the stress response, induce a number of side effects, including strong effects on the

Open access

Gillian A Gray, Christopher I White, Raphael F P Castellan, Sara J McSweeney, and Karen E Chapman

/macrophages and neutrophils regulates their recruitment to sites of inflammation ( Tiganescu et al. 2011 ), phagocytic potential ( Speirs et al. 2004 ) and the release of pro-inflammatory molecules ( Zhang & Daynes 2007 ). 11β-HSD1 inhibition may therefore be

Open access

Jun Zhou, Qilong Wang, Ye Ding, and Ming-Hui Zou

adipose tissue. Insulin resistance is partly caused by chronic low-level inflammation and oxidative stress in adipose tissue ( Guo 2014 ). Infiltration of inflammatory cells, which produce cytokines and oxidants, leads to a local inflammatory environment

Open access

Zhi Zhang, Fang Wang, Bing-jian Wang, Guang Chu, Qunan Cao, Bao-Gui Sun, and Qiu-Yan Dai

liver fibrosis caused by leptin. Recent evidence from our laboratory has indicated that adiponectin might be a natural antagonist of leptin, and further revealed that adiponectin did not alleviate the inflammation of the blood vessels, rather it reduced

Open access

Yanjun Cui and Xianhong Gu

, investigations have been focused on mechanisms underlying the effect of acute HS on intestinal function and integrity. Acute HS causes hypoxia and inflammation of the intestinal epithelium ( Lambert 2009 , Qi et al . 2011 ), both of which regulate intestinal

Open access

Rihua Zhang, Dongming Su, Weidong Zhu, Qiong Huang, Menglan Liu, Yi Xue, Yuanyuan Zhang, Dong li, Allan Zhao, and Yun Liu

models have shown that oophorectomy results in obesity, altered fat distribution, adipose tissue inflammation, and development of fatty liver ( Rogers et al . 2009 , Stubbins et al . 2012 ). Estrogen therapy is believed to have beneficial effects on