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Martin Petkovich Department of Pathology and Molecular Medicine, Queens University, Kingston, Ontario, Canada

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Pierre Chambon Institut de Génétique et de Biologie Moléculaire et Cellulaire (I.G.B.M.C.), Illkirch, France

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members of the steroid/thyroid receptor superfamily, marking the beginning of an important 35-year (and counting) campaign to understand how this key vitamin derived from plants would play such an important role in so many aspects of our molecular

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Pál Gyombolai Department of Physiology, MTA-SE Laboratory of Molecular Physiology, Faculty of Medicine, Semmelweis University, PO Box 259, H-1444 Budapest, Hungary
Department of Physiology, MTA-SE Laboratory of Molecular Physiology, Faculty of Medicine, Semmelweis University, PO Box 259, H-1444 Budapest, Hungary

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András D Tóth Department of Physiology, MTA-SE Laboratory of Molecular Physiology, Faculty of Medicine, Semmelweis University, PO Box 259, H-1444 Budapest, Hungary

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Dániel Tímár Department of Physiology, MTA-SE Laboratory of Molecular Physiology, Faculty of Medicine, Semmelweis University, PO Box 259, H-1444 Budapest, Hungary

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Gábor Turu Department of Physiology, MTA-SE Laboratory of Molecular Physiology, Faculty of Medicine, Semmelweis University, PO Box 259, H-1444 Budapest, Hungary

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László Hunyady Department of Physiology, MTA-SE Laboratory of Molecular Physiology, Faculty of Medicine, Semmelweis University, PO Box 259, H-1444 Budapest, Hungary
Department of Physiology, MTA-SE Laboratory of Molecular Physiology, Faculty of Medicine, Semmelweis University, PO Box 259, H-1444 Budapest, Hungary

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Introduction Seven transmembrane receptors (7TMRs) constitute the largest family of plasma membrane receptors. Most of their intracellular effects are mediated via direct coupling to heterotrimeric G-proteins. To understand the molecular details of

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Fraydoon Rastinejad Nuffield Department of Medicine, University of Oxford, Target Discovery Institute (NDM RB), Oxford, UK

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Introduction The retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are the earliest and most intensely studied nuclear receptors (NRs) for their three-dimensional (3D) structures. Both receptor groups bind to retinoic acids (RAs

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Vincent Giguère Goodman Cancer Institute, McGill University, Montréal, Quebec, Canada
Department of Biochemistry, McGill University, Montréal, Quebec, Canada

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Ronald M Evans The Salk Institute for Biological Studies, La Jolla, California, USA

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of genes is dependent on the action of transcription factors that transduce extra and intracellular signals into specific biological programs. Indeed, a purified fraction containing a receptor for the hormone cortisol (glucocorticoid receptor, GR) was

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Tamar Eigler Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Pituitary Center, Cedars Sinai Medical Center, Davis Building, Room 3066, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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Anat Ben-Shlomo Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Pituitary Center, Cedars Sinai Medical Center, Davis Building, Room 3066, 8700 Beverly Boulevard, Los Angeles, California 90048, USA

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Introduction The anterior pituitary gland is subjected to the stimulatory and inhibitory effects of multiple regulators. Somatostatin (SRIF) and its cognate receptors (sst1–sst5) exhibit a dominant inhibitory role in pituitary gland regulation

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Chunmei Wang Department of Pediatrics, Children’s Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA

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Yong Xu Department of Pediatrics, Children’s Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

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progesterone can bind to their nuclear receptors namely androgen receptors (ARs), estrogen receptors (ERs) and progesterone receptors, respectively, and these receptors function as transcription factors to regulate gene expression ( Yang & Shah 2014

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Victoria Korsos Division of Hematology, Jewish General Hospital, Montreal, Canada
Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada

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Wilson H Miller Jr Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada
Gerald Bronfman Department of Oncology, Jewish General Hospital, Montreal, Canada
Lady Davis Institute for Medical Research, Montreal, Canada

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promyelocytic leukemia ( PML ) and retinoic acid receptor alpha ( RARA ) genes and the expression of a functional PML/RARA protein. The presence of t(15;17) can be confirmed in two ways: by detection of a fused PML/RARA genomic DNA sequence using fluorescence

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J Bian Department of Pediatrics, The Second Affiliated Hospital, Dalian Medical University, 467 Zhongshan Road, Shahekou District, Dalian 116027, China

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X M Bai Department of Pediatrics, The Second Affiliated Hospital, Dalian Medical University, 467 Zhongshan Road, Shahekou District, Dalian 116027, China

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Y L Zhao Department of Pediatrics, The Second Affiliated Hospital, Dalian Medical University, 467 Zhongshan Road, Shahekou District, Dalian 116027, China

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L Zhang Department of Pediatrics, The Second Affiliated Hospital, Dalian Medical University, 467 Zhongshan Road, Shahekou District, Dalian 116027, China

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Z J Liu Department of Pediatrics, The Second Affiliated Hospital, Dalian Medical University, 467 Zhongshan Road, Shahekou District, Dalian 116027, China

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responsiveness to leptin may vary according to the metabolic conditions ( Widdowson et al . 1997 ) and leptin resistance is relevant to leptin receptors ( Lrb ) or their downstream signaling pathway ( Martin et al . 2000 ). Our previous studies showed that the

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Jyotsna B Pippal Steroid Receptor Biology Laboratory, Prince Henry's Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia

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Peter J Fuller Steroid Receptor Biology Laboratory, Prince Henry's Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia

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receptor (MR or NR3C2; Arriza et al . 1987 ). The MR is a member of the steroid/thyroid hormone receptor superfamily of ligand-inducible transcription factors. Other NR in this family include the glucocorticoid (GR or NR3C1; Weinberger et al . 1985

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Sylvia C Hewitt Receptor Biology Group, School of Molecular Biosciences, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA

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Wipawee Winuthayanon Receptor Biology Group, School of Molecular Biosciences, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA

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Kenneth S Korach Receptor Biology Group, School of Molecular Biosciences, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA

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Estrogen receptor The vast majority of estrogen's activities are mediated by the estrogen receptor (ER), a member of the nuclear receptor family of hormone activated transcription factors. Our understanding of the physiological role of estrogen

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