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Dorka Nagy Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, UK
National Heart and Lung Institute, Imperial College London, London, UK

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Hannah Maude Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, UK

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Graeme M Birdsey National Heart and Lung Institute, Imperial College London, London, UK

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Anna M Randi National Heart and Lung Institute, Imperial College London, London, UK

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Inês Cebola Department of Metabolism, Digestion and Reproduction, Section of Genetics and Genomics, Imperial College London, London, UK

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tissue (~80% of its mass) has made it difficult to assess and analyse LSEC-specific aspects of gene expression, chromatin accessibility, and transcription factor (TF) occupancy using bulk liver tissue. With advances in cell isolation techniques and single

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JME-23-0026
Volume/Issue:
Volume 71: Issue 2
Open access
Hiroshi Ishikawa Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

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Tatsuya Kobayashi Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
Evolution and Reproductive Medicine, Medical Mycology Research Center, Chiba University, Chiba, Japan
Fujita Medical Innovation Center Tokyo, Reproduction Center, Tokyo, Japan

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Meika Kaneko Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

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Yoshiko Saito Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

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Makio Shozu Evolution and Reproductive Medicine, Medical Mycology Research Center, Chiba University, Chiba, Japan

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Kaori Koga Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

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one of the subunits of the Mediator, an RNA polymerase II activator-interacting multiprotein complex involved in transcriptional regulation and gene expression. Many studies have been conducted to investigate the characteristic differences between MED

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JME-23-0039
Volume/Issue:
Volume 71: Issue 4
Free access
Sarah Theresa Boyle Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia

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in the nucleus and in the cytoplasm, a multitude of pathways are activated. For instance, upon estrogen binding, ERs dimerize, recruit co-activators to form a functional ER complex, and act as transcription factors by binding to estrogen response

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JME-22-0174
Volume/Issue:
Volume 70: Issue 3
Free access