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Vascular endothelial mineralocorticoid receptors and epithelial sodium channels in metabolic syndrome and related cardiovascular disease

Guanghong Jia

Guanghong Jia Department of Medicine-Endocrinology and Metabolism, University of Missouri School of Medicine, Columbia, Missouri, USA
Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA

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Michael A Hill

Michael A Hill Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA
Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri, USA

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, and

James R Sowers

James R Sowers Department of Medicine-Endocrinology and Metabolism, University of Missouri School of Medicine, Columbia, Missouri, USA
Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA
Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri, USA

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, which is an intracellular steroid hormone receptor and plays an important physiological role in regulating plasma volume, electrolyte homeostasis, and blood pressure ( Jia et al. 2021 ). Recent data indicate that MRs are expressed and are functional in