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Evolution and Reproductive Medicine, Medical Mycology Research Center, Chiba University, Chiba, Japan
Fujita Medical Innovation Center Tokyo, Reproduction Center, Tokyo, Japan
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menopause, indicating that sex steroids, namely, estrogen and progesterone, play crucial roles in the growth and enlargement of UFs. Epidemiological studies have revealed that Black ethnicity, advanced age, obesity, nulliparity, family history of UFs
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and terminal end buds, determining ductal shape and extent of growth ( Ingman et al. 2006 , Fleming et al. 2012 ). Steroid hormone signaling is important in cell–ECM interactions, leading to enzymatic remodeling and subsequent development of