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Hiroshi Ishikawa Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

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Tatsuya Kobayashi Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
Evolution and Reproductive Medicine, Medical Mycology Research Center, Chiba University, Chiba, Japan
Fujita Medical Innovation Center Tokyo, Reproduction Center, Tokyo, Japan

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Meika Kaneko Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

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Yoshiko Saito Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

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Makio Shozu Evolution and Reproductive Medicine, Medical Mycology Research Center, Chiba University, Chiba, Japan

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Kaori Koga Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

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menopause, indicating that sex steroids, namely, estrogen and progesterone, play crucial roles in the growth and enlargement of UFs. Epidemiological studies have revealed that Black ethnicity, advanced age, obesity, nulliparity, family history of UFs

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Sarah Theresa Boyle Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia

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and terminal end buds, determining ductal shape and extent of growth ( Ingman et al. 2006 , Fleming et al. 2012 ). Steroid hormone signaling is important in cell–ECM interactions, leading to enzymatic remodeling and subsequent development of

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