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Vascular endothelial mineralocorticoid receptors and epithelial sodium channels in metabolic syndrome and related cardiovascular disease

Guanghong Jia

Guanghong Jia Department of Medicine-Endocrinology and Metabolism, University of Missouri School of Medicine, Columbia, Missouri, USA
Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA

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Michael A Hill

Michael A Hill Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA
Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri, USA

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, and

James R Sowers

James R Sowers Department of Medicine-Endocrinology and Metabolism, University of Missouri School of Medicine, Columbia, Missouri, USA
Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA
Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri, USA

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) signaling, are regarded as an important mediator in the pathogenesis of metabolic syndrome. Adding to the complexity of this pathway MRs are now appreciated to exist in various tissues outside the kidney, including adipose, skeletal muscle, and