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Xuefeng Peng Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, People’s Republic of China

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Fang He Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, People’s Republic of China

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Yanling Mao Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, People’s Republic of China

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Yihui Lin Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, People’s Republic of China

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Jingwen Fang Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, People’s Republic of China

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Yangchun Chen Department of Nuclear Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, People’s Republic of China

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Zhichun Sun Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, People’s Republic of China

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Yafen Zhuo Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, People’s Republic of China

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Jianjia Jiang Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, People’s Republic of China

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electrotransferred onto a polyvinylidene fluoride membrane. The membrane was blocked with 5% BSA at room temperature for 2 h and then incubated overnight at 4°C with the following primary antibodies: TLR4 (14358; 1:2000), p65 (8242, 1:1000, Cell Signaling

Article Type:
Research Article
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Top-cited articles of 2023
DOI:
https://doi.org/10.1530/JME-21-0019
Volume/Issue:
Volume 69: Issue 2
Restricted access
Sangappa B Chadchan Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA
Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri, USA

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Vertika Singh Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA

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Ramakrishna Kommagani Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA
Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri, USA
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

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signaling and physiological downstream effects ( Fig. 1 ). A decreased β-glucuronidase activity as a result of gut microbial dysbiosis can result in reduced deconjugation of estrogen and a decrease in the level of circulating estrogens ( Flores et al. 2012

Article Type:
Review Article
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DOI:
https://doi.org/10.1530/JME-21-0238
Volume/Issue:
Volume 69: Issue 3
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Bryan B Ho Department of Internal Medicine, Section Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USA

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Clemens Bergwitz Department of Internal Medicine, Section Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USA

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(PTH), regulates phosphate recycling and synthesis of calcitriol (1,25-Dihydroxyvitamin D or 1,25(OH) 2 D) in the kidneys ( Shimada et al. 2004 ). Canonical FGF23 signalling requires the obligatory co-receptor alpha KLOTHO (KL), a transmembrane

Article Type:
Review Article
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DOI:
https://doi.org/10.1530/JME-20-0178
Volume/Issue:
Volume 66: Issue 2
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Seiji Fukumoto Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Tokushima, Japan

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absorption through reducing 1,25(OH) 2 D level ( Fig. 1 ). Figure 1 Actions of FGF23. FGF23 is produced by osteoblasts/osteocytes. FGF23 binds to Klotho/FGF receptor 1 complex and activates several intracellular signaling pathways including

Article Type:
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DOI:
https://doi.org/10.1530/JME-20-0089
Volume/Issue:
Volume 66: Issue 2
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Mathieu Vernier Goodman Cancer Research Centre, McGill University, Quebec, Montreal, Canada

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Vincent Giguère Goodman Cancer Research Centre, McGill University, Quebec, Montreal, Canada
Departments of Biochemistry, Medicine and Oncology, McGill University, Montreal, Quebec, Montreal, Canada

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mitochondrial integrity and function. Regulation of the PGC-1/ERR axis To rapidly respond to variations in nutrient availability or energy demands, the cells have developed key signaling pathways facilitating the constant rewiring of mitochondrial

Article Type:
Review Article
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DOI:
https://doi.org/10.1530/JME-20-0196
Volume/Issue:
Volume 66: Issue 1
Free access
Excel Rio S Maylem Department of Animal and Food Sciences, Oklahoma State University, Stillwater, Oklahoma, USA

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Leon J Spicer Department of Animal and Food Sciences, Oklahoma State University, Stillwater, Oklahoma, USA

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Isadora Batalha Department of Agriculture, Veterinary, and Rangeland Sciences, University of Nevada, Reno, Nevada, USA

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Luis F Schutz Department of Agriculture, Veterinary, and Rangeland Sciences, University of Nevada, Reno, Nevada, USA

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development of follicles from pre-antral to ovulatory size act via endocrine signaling ( Jones & Shikanov 2019 ), while growth factors (i.e. keratinocyte growth factor, hepatocyte growth factor, wingless signaling type factor, etc.) stimulate DNA synthesis in

Article Type:
Research Article
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DOI:
https://doi.org/10.1530/JME-20-0218
Volume/Issue:
Volume 66: Issue 1
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René Lafont Biophytis, Sorbonne Université – BC9, Paris, France
Sorbonne Université, CNRS -Institut de Biologie Paris Seine (BIOSIPE), Paris, France

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Maria Serova Biophytis, Sorbonne Université – BC9, Paris, France

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Blaise Didry-Barca Biophytis, Sorbonne Université – BC9, Paris, France

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Sophie Raynal Biophytis, Sorbonne Université – BC9, Paris, France

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Louis Guibout Biophytis, Sorbonne Université – BC9, Paris, France

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Laurence Dinan Biophytis, Sorbonne Université – BC9, Paris, France

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Stanislas Veillet Biophytis, Sorbonne Université – BC9, Paris, France

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Mathilde Latil Biophytis, Sorbonne Université – BC9, Paris, France

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Waly Dioh Biophytis, Sorbonne Université – BC9, Paris, France

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Pierre J Dilda Biophytis, Sorbonne Université – BC9, Paris, France

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digestion but nowadays also known to be important signaling molecules acting on specific receptors ( Chiang 2013 ). Diversity of steroid mechanisms of action Our concepts of (steroid) hormone mechanism of action have evolved. In the classical scheme

Article Type:
Research Article
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DOI:
https://doi.org/10.1530/JME-21-0033
Volume/Issue:
Volume 68: Issue 2
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Feng Zhang Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

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Qi Xiong Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

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Hu Tao Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

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Yang Liu Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

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Nian Zhang Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

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Xiao-Feng Li Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

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Xiao-Jun Suo Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

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Qian-Ping Yang Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

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Ming-Xin Chen Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China

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5× SDS buffer for 5 min were subjected to 5% SDS-PAGE gels, and then transferred to PVDF membranes (Millipore). The membranes were blocked with skim milk and probed with primary antibodies against ACOX1 (Abcam), C/EBPβ (Cell Signaling Technology

Article Type:
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DOI:
https://doi.org/10.1530/JME-20-0250
Volume/Issue:
Volume 66: Issue 3
Open access
Linfang Li Graduate School of Peking Union Medical College, Beijing, China
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China

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Xiaoyi Zhang The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China

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Hangjiang Ren Graduate School of Peking Union Medical College, Beijing, China

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Xiuqing Huang The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China

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Tao Shen The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China

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Weiqing Tang The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China

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Lin Dou The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China

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Jian Li Graduate School of Peking Union Medical College, Beijing, China
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China

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by affecting RXRa expression during hepatic stellate cell (HSC) activation ( Ji et al. 2009 ). Similarly, miR-24 promoted hepatic lipid accumulation by inhibiting the Insig1/SREBP signalling pathway, leading to fatty liver and raising the plasma

Article Type:
Research Article
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DOI:
https://doi.org/10.1530/JME-20-0324
Volume/Issue:
Volume 68: Issue 1
Restricted access