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multiple transcription factors as well as adaptor proteins ( Essandoh et al. 2016 ). In the current study, bioinformatics analysis has revealed that miR-146a could target toll-like receptor 4 (TLR4), which is also verified by a recent study ( He et al
Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri, USA
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Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri, USA
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
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microbiota principally regulates the estrogen level by secretion of β-glucuronidase (gmGUS), an enzyme that converts conjugated estrogen into deconjugated estrogen in the GI tract facilitating it to bind to estrogen receptors, resulting in subsequent
Sorbonne Université, CNRS -Institut de Biologie Paris Seine (BIOSIPE), Paris, France
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digestion but nowadays also known to be important signaling molecules acting on specific receptors ( Chiang 2013 ). Diversity of steroid mechanisms of action Our concepts of (steroid) hormone mechanism of action have evolved. In the classical scheme
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Departments of Biochemistry, Medicine and Oncology, McGill University, Montreal, Quebec, Montreal, Canada
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dynamics. These processes are finely tuned by metabolic pathways that sense cellular energy needs and impinge on the activity of key transcription factors to control mitochondrial nuclear-encoded gene expression. Nuclear receptors and their cognate hormone
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and organ differentiation locally. FGF23 also stands apart from the intracrine FGFs, which act intracellularly independently of an FGF receptor (FGFR) by interacting with voltage-gated sodium channels and neuronal scaffolding proteins to potentiate
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total testosterone in obese PCOS women ( Li et al. 2018 ). In mice, the asprosin receptor, olfactory receptor ( Olfr734 ) has been identified recently in different tissues including liver, kidney and testis, but has not been studied in ovaries. In a
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
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The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
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miR-23a-3p and miR-23b-3p are members of the miR-23~27~24-2 superfamily. The role of miR-23a/b-3p in regulating hepatic lipid accumulation is still unknown. Here, we found that increased miR-23a-3p and miR-23b-3p levels were accompanied by an increase in the protein levels of the sterol regulatory element-binding protein-1 (SREBP-1) and fatty acid synthase (FAS) in the steatotic livers of mice fed a high-fat diet and leptin receptor-deficient type 2 diabetic mice (db/db). Importantly, overexpression of miR-23a/b-3p in Hep1-6 cells elevated the intracellular triglyceride level and upregulated the expression of Srebp-1c and Fas. Taken together, these results suggested that miR-23a/b-3p enhanced mRNA stability by binding the 5'-UTR of Srebp-1c and Fas mRNA, thereby promoting triglyceride accumulation in hepatocytes.
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absorption through reducing 1,25(OH) 2 D level ( Fig. 1 ). Figure 1 Actions of FGF23. FGF23 is produced by osteoblasts/osteocytes. FGF23 binds to Klotho/FGF receptor 1 complex and activates several intracellular signaling pathways including
